Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 47 for “"Therapeutic Resistance"”.
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Dissecting the molecular mechanisms of therapeutic resistance in cancer
Therapeutic resistance continues to be a persistent challenge in medical oncology. In clinical settings, resistance can occur at the beginning of treatment, or may be acquired after an initial clinical response to the therapy. Several mechanisms of drug resistance have been described in cancer, …
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Overcoming therapeutic resistance in glioblastoma using novel electroporation-based therapies
… patient outcome is attributed to GBM's inherent therapeutic resistance. Marked heterogeneity, extensive local invasion within the brain parenchyma, and profound immunosuppression within the tumor microenvironment (TME) are some of the unique features that drive GBM therapeutic resistance. …
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Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
… (mCRC), it has historically been a challenging therapeutic target. The recent approval of novel covalent inhibitors selective for KRASG12C mutation have entered the clinic, which has not only marked a major milestone in cancer drug discovery but has also intensified efforts to directly target …
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Identification and Targeting of Therapeutic Resistance Mechanisms in Inflammatory Breast Cancer
… in the apoptotic program. The development of therapeutic resistance is a significant barrier to successful treatment in IBC, and thus, strategies targeting the mechanisms that drive drug resistance could prevent or reverse therapeutic resistance, significantly improving patient prognosis. …
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Role of X-Linked Inhibitor of Apoptosis Protein in Therapeutic Resistance of Inflammatory Breast Cancer Cells
… of cancer cells to undergo apoptosis may lead to therapeutic resistance. Inflammatory breast cancer (IBC) is a highly aggressive subtype of breast cancer that is often characterized by ErbB2 overexpression and ErbB2 activation. ErbB-targeting is clinically relevant using trastuzumab (anti-ErbB2 …
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Receptor tyrosine kinase target validation and combinatorial strategies to circumvent small molecule therapeutic resistance in canine metastatic insulinoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Receptor tyrosine kinase target validation and combinatorial strategies to circumvent small molecule therapeutic resistance in canine metastatic insulinoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Investigating The Rare Aneuploid Cells in Normal Breast and Therapeutic Resistance in Triple Negative Breast Cancer Using Single Cell Genomics
… breast cancer (TNBC) under the chemo-resistance context. TNBC is an aggressive subtype that is frequently treated with chemotherapy, but only half of the patients have a complete response. Here, we performed single cell transcriptomic analysis of 427,857 cells from treatment-naïve …
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Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer
… mammary epithelial cells are believed to coerce therapeutic resistance. On the other hand, population-wide screenings have increased diagnosis of women with breast cancers without specificity for the tumors with an aggressive phenotype. Hence, identification of the cancer cell's intrinsic …
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Assessment of the in vitro efficacy of aspirin and aspirin analogues in combination with standard chemotherapeutics in glioma cell lines
… to the current treatment regimen, often due to therapeutic resistance, however combination therapies have been proven to have a beneficial effect on the prognosis of patients. Aspirin, one of the most commonly used drugs reduces the viability and proliferation of glioblastoma both in vitro and …
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Application of the single cell genomics in deciphering tumor heterogeneity and its role in tumor progression and drug resistance
… heterogeneous, leading to tumor progression and resistance to therapy. However, clear genetic drivers of progression, metastasis, and therapeutic resistance are identified in only a subset of tumors, pointing to non-genetic contributors to cancer progression. Also, somatic evolution in cancer is …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
… cell-like characteristics, providing them with therapeutic resistance and conferred tumor recurrence. Although metabolism plays a fundamental role in essentially every function of a cell, little is known about how the EMT programme involves in regulating cell’s metabolism contributes to the …
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Investigating The Role of Abro1 In Dna Damage-Induced Immune Response
… human cancer that is associated with metastasis, therapeutic resistance, and poor prognosis. During replication stress, the replication fork stalls and forms a reversed fork which may be degraded by several DNA nucleases. At the stalled fork, genome stability is maintained by fork end protection …
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Reprogramming the Tumor Microenvironment in Desmoplastic Tumors to Potentiate Cancer Immunotherapy
… to re-engineer the desmoplastic TME to overcome therapeutic resistance to immune checkpoint blockade (ICB), and developed an approach to identify predictive biomarkers of responsiveness to ICB. First, we developed a novel TME-activated polymeric material that can be conjugated with a class of …
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Dissecting Tumor Heterogeneity In Lung Cancer
… tumor tissue that is ever evolving and poses a therapeutic challenge for sustained benefit. Strategies for targeting lung cancers are largely guided by the genetic alterations identified in the tumor specimens. However, in order to gain a better understanding of lung cancer progression and …
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Defining and Targeting Epigenetic Rewiring During Tumor Progression
… that epigenetic dysregulation directly promotes therapeutic resistance and tumor progression. While genetic alterations have been shown to promote tumor progression, the contribution of non-genetic drivers of recurrence remains unexplored. In the current work, we utilized genetically engineered …
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Abelson Kinase Based Regulation of Tumor Cell Invasion in HNSCC
… of chemoradiation often combined with targeted therapeutic agents. However, the five-year survival rate for patients that relapse is < 50%. Patients with recurrent or metastatic disease have a very poor prognosis and typical survive < 12 months due to therapeutic resistance and loco-regional …
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Computational analysis of cell-cell communication in the tumor microenvironment
… including tumorigenesis, tumor progression, and therapeutic resistance. As a result, targeting receptor-ligand interactions, for instance with immune check-point inhibitors, can provide significant benefit for patients. However, our knowledge of this complex network of cell-cell interactions in a …
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Targeting Calpain-1 and Calpain-2 for Prevention of Breast Cancer Metastasis: In Vivo Insights and Drug Discovery Approaches
… cysteine proteases, are a potential novel therapeutic target in cancer as they are upregulated in multiple cancer subtypes, including breast cancer, and have been implicated in tumor progression, metastasis, and therapeutic resistance. To evaluate calpains’ potential as therapeutic targets, …
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