Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Therapeutic Hypothermia"”.
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Timing of Therapeutic Hypothermia & Short-Term Infant Outcomes
… death. Current evidence recommends initiating Therapeutic Hypothermia (TH), as early as possible, however, research specifically describing TH timing in relation to short-term infant outcomes is limited with mixed results.</p> <p><strong>Purpose:</strong> Examine TH timing (TH initiation time & …
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Cardiac arrest and therapeutic hypothermia: Prognosis and outcome
Abstract Therapeutic hypothermia (TH) is the only treatment available to reduce neurological sequels for unconscious patients following cardiac arrest (CA). TH requires sedation and muscular relaxation, obscuring the clinical neurological examination for estimation of prognosis, and clinical …
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The Pattern of Ventricular Repolarization during Therapeutic Hypothermia
Therapeutic hypothermia (TH) is used in neuroprotection following cardiac arrest. Accidental hypothermia has been itself known to cause prolongation of the corrected QT interval (QTc). QTc prolongation can cause polymorphic ventricular tachycardia (VT) and ventricular fibrillation (VF). The …
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Predicting adverse neurological outcomes in infants receiving therapeutic hypothermia for hypoxic ischemic encephalopathy
… oxygen and/or blood flow to the brain. Despite, therapeutic hypothermia (TH) treatment, consequences of HIE can include life-long disability or even death. Current diagnostic tools may not always be associated with outcomes. Thus, better tools are needed for prognostication. Near-infrared …
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Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in sub-saharan africa: a scoping review
There are divergent views regarding therapeutic hypothermia (TH) for neonatal hypoxic ischaemic encephalopathy (HIE) in low- and middle-income countries. The aim of this review was to synthesize the literature describing TH for HIE in sub-Saharan Africa by searching Pubmed, Scopus, Google Scholar, …
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Influence of mild therapeutic hypothermia on the inflammatory response after successful resuscitation from cardiac arrest
… document conflicting data on the influence of hypothermia on cytokine release in various settings, no data exist if hypothermia affects the inflammatory response after successful cardiopulmonary resuscitation. MATERIALS AND METHODS: Arrest- and treatment-related variables of 71 patients were …
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The influence of birth site on short-term outcomes of encephalopathic newborn infants treated with therapeutic hypothermia at Groote Schuur Hospital, Cape Town, South Africa
… (HIE) should be treated with induced hypothermia within 6 hours of birth, but many of the affected babies are born outside treatment centers. There are conflicting data describing the influence of birth site on outcome after HIE - and no published data from South Africa. Objective: To …
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The perceived barriers to timely therapeutic hypothermia treatment for neonates diagnosed with hypoxic-ischaemic encephalopathy when born outside the cooling facility within the private healthcare setting
… to a hypoxic event. The recommended treatment is therapeutic hypothermia (TH) provided at certain neonatal facilities and should commence within the treatment window of 6 hours (1). The outborn neonates are at a disadvantage because they require timely transport to a TH-capable neonatal ICU. The …
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Early prediction of hypoxic ischaemic encephalopathy in newborn infants in a resource-limited setting
… particularly in resource-limited regions. Therapeutic hypothermia initiated within the first 6 hours of life, in settings that can offer neonatal intensive care, is a therapy that can reduce death or severe disability in newborn infants with moderate or severe HIE. Therapeutic hypothermia …
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Der Einfluss von milder therapeutischer Hypothermie auf die Vorhersagekraft des Serummarkers S-100 Protein bezüglich des neurologischen Outcomes nach erfolgreicher präklinischer Reanimation
… lacking.AIM: To investigate the effects of mild therapeutic hypothermia on the release of the astroglial protein S-100 post CPR in survivors of out of hospital cardiac arrest. METHODS: Prospective, observational study during a two year period, involving medical emergen-cy services and five …
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Cardioprotective treatment strategies
… receptor to the activated complement factor C5a. Hypothermia has been shown to suppress the development of I/R injury. In this thesis, the cardioprotective effects of ADC-1004 (paper I), apyrase (paper II) and hy- pothermia (paper III) were investigated. The effects of hypothermia on coronary t-PA …
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Perinatal hypoxic-ischemic brain injury – characterization, mechanisms and treatment
… of injury that are poorly attenuated by therapeutic hypothermia in order to find suitable additive treatments, such as Exendin-4. I showed that global cerebral ischemia was associated with a striking increase in concentration of adenosine triphosphate in the cerebrospinal fluid at 6 hours …
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Closing Research Gaps for Cerebral Palsy Prevention and Magnesium Sulphate Neuroprotection
… with CP data from 96 RCTs (15,885 children). Therapeutic hypothermia in late preterm or term neonates with hypoxic-ischaemic encephalopathy reduced CP risk (high-quality evidence), and prophylactic methylxanthines for endotracheal extubation in preterm neonates probably reduced CP risk …
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Capsinoids, Non-Pungent TRPV1 Agonists, Induce a Mild Hypothermia That Provides Short- and Long-Term Neuroprotection After Ischemic Stroke
<p>Therapeutic hypothermia (TH) has demonstrated neuroprotection in instances of cardiac arrest and neonatal hypoxia/ischemia but faces different challenges in application to stroke due to the activation of cold defense mechanisms in conscious patients. This dissertation examines the efficacy and …
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Identification, mechanisms and treatment of perinatal brain injury
… in neuronal vulnerability to hypoxia-ischaemia. Therapeutic hypothermia is incompletely neuroprotective in term neonates, and not available in preterm neonates. I showed that both low-dose melatonin and a novel inhibitor of nNOS were partially neuroprotective when administered prophylactically …
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The mechanisms of aquaporin expression and translocation in cerebral pathologies
… direct blocking of its pore could provide novel therapeutic benefits. The research in this thesis primarily elucidates the regulatory mechanisms involved in processes of hypotonicity and hypoxia mediated AQP4 translocation in primary astrocytes and examines current therapies for cerebral oedema …
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Classification of Electroencephalogram in Ovine Model of Perinatal Hypoxia by Movement of the Autoregressive Model Parameters
… requires immediate medical intervention, e.g., therapeutic hypothermia. HIE due to acute perinatal asphyxia remains an important cause of mortality and neurodevelopmental impairment in childhood. HIE accounts for mortality numbers in excess of 840,000 annually or 23% of all neonatal deaths …
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Pharmacologically Replicating Metabolic Protective Mechanisms of Hypothermia in Cardiac Arrest
… and neurological injury. Rapid application of therapeutic hypothermia is one of few therapies which consistently improves neurological outcomes in animal models; however, clinical trials have yielded disappointing results which may be explained by inadequate cooling rates provided by currently …
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Membrane Stabilizing Copolymer Poloxamer 188 in Preclinical Models of Acute Myocardial Infarction Reperfusion
… ischemic pre-and post-conditioning, and therapeutic hypothermia have been successful in animal studies but have exhibited mixed results in clinical trials. Several cellular events that occur in ischemia including calcium overload and reactive oxygen species (ROS) generation, inflammation …
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Kardioprotektion durch therapeutische Hypothermie
Einleitung: Die ischämische Herzkrankheit ist weltweit die häufigste Todesursache. Therapeutische Hypothermie (TH) gilt als anerkannte Intervention zur Neuroprotektion bei Patienten mit einer durch Herzkreislaufstillstand oder perinatale Asphyxie bedingten Ischämie des Gehirns. Der Einfluss von …
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