Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 245 for “"Therapeutic Efficacy"”.
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Therapeutic Efficacy of P53 Restoration In Mdm2-Overexpressing Tumors
… work suggests that p53 restoration confers therapeutic potentials even to tumors with high levels of Mdm2.</p>
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Evaluating The Therapeutic Efficacy of Grb2 Inhibition In Ovarian Malignancies
… <p><strong>Conclusions:</strong> L-Grb2 has therapeutic efficacy in preclinical models of ovarian cancer. These findings support he clinical development of L-Grb2 for treatment of cancer.</p>
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Engineering periodic short hairpin RNA delivery systems for enhanced therapeutic efficacy
… presents a highly promising approach for cancer therapeutics via specific silencing of disease-implicated genes, but its clinical translation remains severely limited by barriers in delivering short interfering RNA (siRNA). Numerous delivery vehicles have been developed to protect siRNA from …
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The Utility of Immune Function Profiling in Rheumatoid Arthritis Therapeutic Efficacy Monitoring
… disease, if a diagnosis and an effective therapeutic regimen is not established quickly. Identifying when a therapy is proving ineffective can be difficult, however, and is reliant upon accurate formal joint counts, CRP measurements and patient global assessments. These are potentially …
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The therapeutic efficacy of action potential therapy in the treatment of myofascial pain syndrome
A dissertation submitted in partial compliance with the requirements for a Master's Degree in Technology: Chiropractic at Technikon Natal, Durban, South Africa, 2001.
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Evaluating The Therapeutic Efficacy of Restoring Wild-Type P53 Activity In P53-Mutant Tumors
… evolving and gaining more attention in cancer therapeutics research, with several small molecule compounds currently in preclinical and clinical trials. However, it remains largely unknown what types or proportions of <em>p53</em>-mutant tumors will respond to p53 restoration-based …
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Development of second-generation amphotericin B molecular prosthetics for enhanced therapeutic efficacy in cystic fibrosis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Toward understanding and mitigating heterogeneity in bone marrow stromal cell cultures for improved therapeutic efficacy
… - as well as which distinct phenotypes elicit therapeutic responses of interest - remains an open challenge. This lack of characterization confounds studies focused on basic cell behavior as well as translational applications, and U.S. Food & Drug Administration approval for BMSC therapies has …
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The therapeutic efficacy of invasive needling techniques in the management of myofascial pain and dysfunction syndrome
A dissertation submitted in partial compliance with the requirements for a Master's Degree in Technology: Chiropractic, Technikon Natal, Durban, South Africa, 1996.
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Approaches for Enhancing Therapeutic Efficacy of a Novel IL-10 Gene Family Member: MDA-7/IL-24
… human cancers. The first chapter explored the efficacy of a tropism-modified Ad-based cancer gene therapy approach for eradicating low CAR colorectal cancer cells. We show that in low CAR human colorectal cancer cells (RKO), a recombinant Ad.5/3 virus delivering mda-7/IL-24 (Ad.5/3-mda-7) is …
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The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
… adenovirus Delta-24-RGD has shown safety and efficacy in clinical trials for high-grade gliomas. Strategies to improve the efficacy of oncolytic virotherapy have aimed to heighten the immunogenicity of oncolytic viruses, either by incorporating immune-stimulating transgenes or by combining …
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Synergistic Effects Of Garcinol And Gemcitabine In Enhancing Therapeutic Efficacy In Pancreatic Adenocarcinoma Cells And Its Effect On Microrna Profile
… EFFECTS OF GARCINOL AND GEMCITABINE IN ENHANCING THERAPEUTIC EFFICACY IN PANCREATIC ADENOCARCINOMA CELLS AND ITS EFFECT ON MICRORNA PROFILE</p> <p>By</p> <p>MANSI PARASRAMKA</p> <p>ADVISOR: DR. SMITI V. GUPTA</p> <p>MAJOR: NUTRITION AND FOOD SCIENCE</p> <p>DEGREE: DOCTOR OF PHILOSPHY</p> <p>Human …
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Comparison of the therapeutic efficacy of SNAP-tag fusion protein and the synergistic actions of chemotherapy and photodynamic therapy in killing resistant melanoma
… this study primarily aimed to investigate the efficacy of the synergistic actions of chemotherapy (Dacarbazine:DTIC) and hypericin-activated photodynamic therapy (HYP-PDT) in reducing chemoresistance in DTIC resistant (UCT Mel1DTICR2) and non-resistant melanoma cells (UCT Mel-1). To achieve …
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Kratom Alkaloid Mitragynine: Therapeutic Role and Potential Utility Against Chemotherapy-Induced Peripheral Neuropathy
… often leading to disruption or cessation of chemotherapeutic treatment and complicating an individual’s cancer prognosis. Current pharmacological treatments for combatting CIPN are widespread yet are all accompanied with the same hindrances – they are limited in therapeutic efficacy when …
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Inhibition of human platelet aggregation by perhexiline maleate : mechanisms and therapeutic implications / Scott Richard Willoughby.
… effect which may contribute to its proven therapeutic efficacy.
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Cycled Pulsing for Prostate Tumor to Mitigate Thermal Damage, While Conserving the Ablation Area
… pulse schemes on the temperature fluctuation and therapeutic efficacy. The partitioning of pulses and interpulse delays decreased the temperature rise during the IRE treatment, while the ablation areas of the experimental groups were maintained in close range to the control group. The lethal …
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Sensitivity and Specificity of Detecting Premalignant Pancreatic Lesions by Hyperpolarized Magnetic Resonance
… <em>in vivo</em> in real time. Concurrently, the therapeutic efficacy of a preventative treatment was assessed non-invasively with HP MR. <em>Ex vivo</em> metabolomics based on NMR spectroscopy and histology were employed to validate and compliment the <em>in vivo</em> imaging data. These studies …
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Integrative mathematical modelling of drug responses in breast cancer PDTXs and ex vivo PDTCs
… pre-clinical studies into tumour biology and therapeutic efficacy.
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Generation and in vivo validation of multi-functional antibody-fusion proteins for cancer therapy
… necessitating the development of innovative therapeutic approaches. Immunotherapy has revolutionized cancer treatment, introducing novel strategies such as checkpoint inhibitors, antibody-drug conjugates, and CAR-T cell therapies. Recombinant cytokines have been explored for decades in cancer …
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Novel approaches and pharmacological considerations in melanoma treatment
… known to be extremely resistant to common chemotherapeutics, and difficult to treat once metastasised. The prognosis of malignant melanoma is strongly dependent on early detection and disease stage. Recently a number of promising anti-melanoma therapies have been developed, such as anti-CTLA4 …
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