Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Therapeutic Drug Monitoring (TDM)"”.
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Using electronic methods of adherence monitoring and therapeutic drug monitoring (TDM) to eliminate discordance between antiretroviral adherence and virological failure
… to improve outcomes. We explored ideal adherence monitoring methodology for a large public sector ART clinic in Cape Town. Methods: We designed a randomised controlled study for ART-naïve individuals to determine whether text messaging after a missed dose would improve adherence recorded by an …
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Innovative analytical methods for Central Nervous System Drug analysis in biological fluids
… number of central nervous system (CNS) drugs have been approved and introduced on the market for the treatment of many psychiatric and neurological disorders, including psychosis, depression, Parkinson disease and epilepsy. Despite the great advancements obtained in the treatment of CNS …
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Quantitation of Anti-Infectious Disease Molecules Utilizing Paper Spray Mass Spectrometry
… agents increases the likelihood of therapeutic failure and resistance. Dosing optimization, while an attractive approach to combat these issues, is difficult to implement due to the different pharmacokinetics of each individual. These limitations highlight the inadequacies of a …
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Development of novel extraction and separation methods for the determination of anthracyclines and taxanes simultaneously from biological matrices
… to patients and that accurate measurement of drug levels during chemotherapy is proven to be more beneficial to patients, currently no chromatographic method exists for the measurement of any anthracycline and taxane drugs in a single assay. It would be useful to carry out therapeutic drug …
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Therapeutic drug monitoring of anti-TNF biologics in patients with Crohn's disease at Groote Schuur Hospital, Cape Town, South Africa
… (UC) and Crohn's disease (CD). The advent of Therapeutic Drug monitoring (TDM) in recent years has allowed further optimisation of their use. TDM involves the measurement of serum trough levels (TLs) and anti-drug antibodies (ADAs), with higher serum drug concentrations and the absence of ADAs …
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Simultaneous quantification of first-line anti-tuberculosis drugs and metabolites in human plasma
… in Africa and Asia (1). Therapy recommended for drug sensitive TB consists of a cocktail of isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (EMB), all given in a 2-month intensive phase, followed by only INH and RIF in a 4-month continuation phase. Clinical studies seeking to …
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Evaluation of adherence to antiretroviral therapy using efarivenz as a marker
… non-adherence may lead to the development of HIV drug resistance, which may lead to virologic failure and treatment failure. Therapeutic drug monitoring (TDM) has been reported to be the most efficient method to assess treatment adherence in HIV individuals, since it quantifies the concentration …
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The Plasma, Whole Blood and Intracellular Concentrations of Antiretroviral Agents in South African Children Receiving Combination Antiretroviral Therapy with and without Concomitant Antitubercular Treatment
… plasma concentrations in children. Although therapeutic drug monitoring (TDM) is recommended in selected patients (including young children and patients receiving concomitant antitubercular treatment), TDM is seldom available in resource-constrained countries. There is an urgent need to …