Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 274 for “"Therapeutic Approach"”.
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Exosome- and Microrna-based Therapeutic Approach for Tendinopathy
… underlying pathology; however, stem cell-based approaches aimed at repairing diseased tissues may overcome this limitation. Therapeutic effects of stem cells may be due in part to paracrine actions, including some mediated by exosomes – extracellular vesicles secreted by cells that play a role …
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Dying children and their families : a therapeutic approach for clinical psychologists
… is reviewed and suggestions for possible further therapeutic intervention with the child and his family are made. It is concluded that the psychologist is a potentially valuable source of support for both the child and his family, someone who can improve the quality of the child's life and …
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A therapeutic approach to chronic myeloid leukaemia using short hairpin RNA molecules
Chronic myeloid leukaemia (CML) was one of the first cancers to be linked to a chromosomal abnormality, the Philadelphia chromosome. This chromosome results in a translocation between chromosomes 9 and 22, where the ABL gene on chromosome 9, a tyrosine kinase, is translocated to the BCR gene region …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… of diabetes mellitus. To investigate therapeutic targets against insulin resistance, this thesis explores the mechanism of action of pharmacological agents and exogenous peptides known or suspected to modify insulin action. These included leptin, a hormone primarily involved in the …
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Targeting heart rate as a novel therapeutic approach in acute heart failure
Background and hypothesis: Standard pharmacological treatment for heart failure improves cardiac remodelling and survival in the setting of chronic heart failure, but is suboptimal in cases of acute heart failure (AHF). Peripartum cardiomyopathy (PPCM), de-novo hypotension (often due to …
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Molecular bases, pathogenic mechanisms and possible therapeutic approach in Leber's Hereditary Optic Neuropathy
… on LHON expression, and attempt a possible therapeutic approach using the cybrids cell model. We generated novel structural models for mitochondrial encoded complex I subunits and a conservation analysis and pathogenicity prediction have been carried out for LHON reported mutations. This …
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Semantically-Based Therapeutic Approach Through Aided Language Stimulation in a Child with Autism Spectrum Disorder
… in the context of a semantically-based therapeutic approach was studied using a single-subject design with a 7-year-old child with autism spectrum disorder who was minimally verbal. Techniques for increasing word retrieval (e.g., the repeated modeling of a small number of target …
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NEURAL PRECURSOR/STEM CELL-BASED THERAPY: A NOVEL THERAPEUTIC APPROACH FOR THE TREATMENT OF RETT SYNDROME
… molecular pathways complicate the finding of a therapeutic approach; indeed, patients are treated only to ameliorate secondary phenotypes. Among all the preclinical works, no study assessed the possible efficacy of neural precursor/stem cell (NPC) transplantation, that has already been proved …
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AR-A IPSCS: GENERATION OF AN ADVANCED CELLULAR MODEL TO INVESTIGATE A NOVEL THERAPEUTIC APPROACH FOR SBMA
… nucleus. Given these characteristics, an ideal therapeutic approach for SBMA should reduce the ARpolyQ aggregation while maintaining its transcriptional activity. Interestingly, the AR mRNA transcript presents more than one translational start codon: in particular, an AUG (AUG-II) downstream of …
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Photodynamic Therapy As An Effective Therapeutic Approach In Mame Models Of Triple Negative And Inflammatory Breast Cancers
<p>Introduction: Photodynamic therapy (PDT) is a minimally invasive, FDA approved therapy for</p> <p>treatment of several indications including endobronchial and esophageal cancers that are</p> <p>accessible to light. Triple negative breast cancer (TNBC) and inflammatory breast cancer (IBC)</p> …
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… factor in cancer progression as a therapeutic strategy in PDAC management, particularly in conjunction with the chemotherapeutic agent, Gemcitabine. Using publicly available datasets, we first demonstrated that upregulation of PLAU, the gene encoding uPA, is associated with poor …
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Functional Protein Delivery Using Polymeric Nanoparticles: A Novel Therapeutic Approach to Alpha-Synuclein Aggregation and Parkinson's Disease
… shown to deliver otherwise impermeable drugs to therapeutic levels in vivo across the blood-brain barrier (BBB). It was not yet known, however, whether such particles could also be taken up by neurons and other brain cells. Here we report the novel use of polybutylcyanoacrylate nanoparticles …
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Regulating the bioactivity of placental growth factor in the aging outer retina as a new therapeutic approach to age-related macular degeneration
Age-related macular degeneration (AMD) is a sight-threatening disease caused by degeneration of the macula. Late disease presents as neovascular AMD (NV-AMD) or geographic atrophy (GA). Advances in angiogenesis research have led to the development of treatments for patients with NV-AMD. However, …
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Working with bereaved people: a psychotherapy training action research study: working towards an epistemology of grief as the therapeutic approach with a bereaved population.
… and an over emphasis on schoolism in psychotherapeutic trainings have further contributed to a frequent failure in therapeutically meeting the lived experience of those who encounter both prolonged and traumatic grief experience. This research challenges psychotherapy practitioners to adopt …
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Suicide Gene therapy for Malignant Gilomas using Neural Stem Cells
… neurosurgical techniques and various multimodal therapeutic approach have been developed for malignant gliomas, these can not save the patients from the tumors due to infiltrating behavior of these glioma cells. Here, author investigated the possibility of treatment for the malignant gliomas with …
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Autistic Spectrum Disorder: Behaviour Therapy, Relationship Therapy and Play; A Combined Future?
… with Autistic Spectrum Disorder, an integrated therapeutic approach in an everyday environment.
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Preclinical Evaluation Of Infrared Light Therapy In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy
… to the development of a potential novel therapeutic approach in the management of brain injuries arising as a result of perinatal asphyxia</p>
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