Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 367 for “"Therapeutic Agents"”.
-
Nose to Brain Delivery of Therapeutic Agents
… neurotrophic factor (BDNF)], neurotrophinogenic agents (ex: carnosic acid) and antibiotics (ex: cefotaxime) to brain via nose-brain pathway using chitosan as barrier modulating agent was investigated. In vitro permeation studies of fluorescein isothiocyanate dextran (FD40k) across bovine …
-
Nucleic acid-templated assembly of therapeutic agents
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
-
Development of therapeutic agents for myotonic dystrophy type 1
… leading to hundreds of splicing defects. DM1 therapeutic efforts have been focused on inhibiting the interaction between r(CUG)exp and MBNL1 proteins, because it is estimated that over 80% of DM1 splicing defects are related to MBNL1 sequestration. This dissertation focuses on the development …
-
TDiscovery and Development of Novel Therapeutic Agents for Advanced Melanoma
… a strong basis for the development of novel chemotherapeutic drugs for advanced melanoma.</p> <p>Furthermore, the chemists in our group also synthesized some new imidazole and imidazoline analogs by focusing on the SAR studies of the central five-member ring. Although the current compounds …
-
A modular device for vaginal administration of multiple therapeutic agents
In this project, the aim is to develop a new multipurpose prevention technology (MPT) platform to help address the global health burdens associated with sexually transmitted infections (e.g. HIV-1, HSV-2, HPV) and unmet need for contraception, which disproportionately affect young women in low and …
-
Inhibitors of human cathepsin L and cruzain as therapeutic agents.
… of Trypanosoma cruzi organism and is a validated therapeutic target for the development of new chemotherapy. Chagas disease, a result of Trypanosoma cruzi infection, is the third largest parasitic disease challenge worldwide after malaria and leishmania and there is an urgent need for development …
-
A compatibility profile of selected therapeutic agents in balanced electrolyte solutions
… solutions and a group of commonly used therapeutic agents. Visual, spectrophotometric and microbiological assay techniques are to be used to establish the compatibility profiles of these admixtures.</p>
-
Ursolic acid and oleanolic acid as novel therapeutic agents in breast cancer
… properties of UA and OA and their validity as therapeutic agents. The MCF-7 breast cancer cell line and the immortalized normal mammary cell line, MCF-10A were treated with different concentrations of UA and OA for 6hrs, 12hrs, 24hrs, 48hrs, and 72hrs respectively. Cell morphology was studied …
-
Developing novel therapeutic agents for Acanthamoeba infection and investigating the process of encystment
… to these drugs. There is an urgent need for new therapeutic agents to eradicate the AK infection. This study focuses on the mechanism by which Acanthamoeba may distinguish between trophozoite, cyst and the newly identified lifecycle known as protocyst. The current study has tested 56 novel and …
-
Alchemistic Polymers for the Delivery of Therapeutic Agents in Treatment of Pediatric Tracheomalacia
… initiators such as contrast medium and therapeutic agents. The characterization of these polymers leads to the optimization of a coating platform. Using a factorial design, a library of drug delivery particles for the delivery of an anti-inflammatory agent was generated. The novel …
-
Advanced micro/nano-encapsulation: Controlled release of therapeutic agents and cell-based therapy
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
-
Natural Polymeric Carriers for Local Delivery of Therapeutic Agents to Promote Enhanced Bone Regeneration
… to bone regeneration. In order to lower the therapeutic rhBMP-2 dose, targeting rhBMP-2 antagonists such as noggin through substrate-mediated delivery of siRNA complexes can potentially increase local rhBMP-2 efficacy. Fibrin, a natural polymer involved in bone healing, is able to …
-
DISEASE-MODIFYING APPROACHES TO MULTIPLE SCLEROSIS: DESIGN AND SYNTHESIS OF NOVEL POTENTIAL THERAPEUTIC AGENTS
… aimed at identifying new B4GALT6 inhibitors as therapeutic agents for the treatment of MS. A computational approach was applied for rational drug design. A homology model of B4GALT6 was created, refined and validated. Subsequently, new potential ligands were identified using a large virtual …
-
Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
… decorated mixed nanomicelles encapsulating chemotherapeutic drug paclitaxel (PTX) and P-glycoprotein inhibitor ritonavir (RTV). HA was conjugated to poly (lactide) co-(glycolide) (PLGA) polymer by disulfide bonds, (HA-ss-PLGA). HA is a natural ligand for CD44 receptors overexpressed on breast …
-
Approaches to the assembly of potent therapeutic agents for the treatment of myotonic dystrophy
… better efficacy and can be used as multi-target agents.
-
COMPUTATIONAL DESIGN OF PEPTIDES AND PEPTIDOMIMETICS AS POTENTIAL THERAPEUTIC AGENTS TO SATISFY PRESSING MEDICAL NEEDS
Over the past two decades, peptide drug discovery showed a dramatic increase of interest due to the recent scientific findings and achievements made on the pharmacokinetic profile and peptide delivery. In addition, it is possible to mimic the secondary structure and the pharmacological effects of …
-
A combination of therapeutic agents for the control of dental plaque and gingivitis in man
Contains fulltext : mmubn000001_15784496x.pdf (Publisher’s version ) (Open Access)
-
Small Gadolinium Oxide Contrast Agents: A Novel Class of Multi-Modality Contrast and Therapeutic Agents
… of gadolinium oxide particulate contrast agents as a novel class of prototype multi-modality contrast agent. In chapter 2 an analysis of the MR contrast enhancement and X-ray attenuation properties of small particulate gadolinium oxide and gadolinium oxide albumin microspheres for MR and …
Page 1 of 19