Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Theranostics"”.
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Leveraging Bio-Inspired Molecules for Cancer Theranostics
<p>A variety of molecules can be radiolabeled and delivered to a cancer site for the purposes of diagnostics and therapy. Among the most promising of tumor targeting molecules are peptides and antibodies. These bio-inspired molecules can be designed and synthesized to target and respond to cancer …
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Polystyrene coated iron-platinum drug delivery platforms for theranostics
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] Cancer is the second leading cause of death in the United States, exceeded only by heart disease, and it is estimated that one in every four deaths is due to cancer.1 Many therapeutic techniques that are currently used …
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Synthesis and functionalisation of metal and metal oxide nanoparticles for theranostics
Metal and metal oxide nanoparticles including calcium oxide, gold, and superparamagnetic iron oxide nanoparticles (SPIOs) were synthesised using a range of techniques including reduction, co-precipitation and spinning disc technology. SPIOs were primarily synthesised via a co-precipitation method …
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DEVELOPING SURFACE-MODIFIED LANTHANIDE-DOPED NANOPARTICLES AS A BRAIN TUMOR THERANOSTICS
Glioblastoma (GBM), a grade IV astrocytoma is highly aggressive and lethal. Recently, nano-based systems were widely used in GBM studies because of the ability to traverse the blood-brain-barrier successfully. However, there are still several major challenges. Lanthanide-doped nanoparticles …
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Development and Evaluation of Novel Anti-HER2 Theranostics Against HER2-Positive Breast Cancer
… thesis is that safe and more effective anti-HER2 theranostics can improve the management of HER2-positive BC. This thesis aimed to develop more potent trastuzumab radioimmunoconjugates (RICs) and novel trastuzumab/pertuzumab antibody-drug radioconjugates (ADRs) radiolabeled with beta and alpha …
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OPTIMIZATION OF THE PRODUCTION OF TERBIUM RADIONUCLIDES FOR THERANOSTIC APPLICATIONS
… radioactivity in 1934. Among the developments, theranostics has emerged as a promising approach combining diagnostics and therapy using radiopharmaceuticals labeled with chemically identical radionuclide pairs. In particular, the terbium isotopes 149Tb, 152Tb, 155Tb, and 161Tb have shown great …
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Development of Gold-Magnetite Hybrid Nanoparticles for Advanced Radiotherapy
The term “theranostics” defines the effort to develop individualized therapies by the combination of diagnostic and therapeutic functions in the same agent. Gold-magnetite hybrid nanoparticles (H-NPs) are proposed as innovative theranostic nanotools for imaging-guided radiosensitization of cancers. …
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Chemoligand therapy for metastatic castration-resistant prostate cancer
… drug the benefits of microtubule inhibition and theranostics, which are both standard of care in mCRPC. To achieve this, the design of the drug built on the general structure of chelator-containing glutamate-ureido-based radiopharmaceuticals for radioligand therapy. After screening taxanes, …
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Co-opting disease pathology for personalized medicine; utilizing endogenous biomaterials to generate theranostic nanoparticles
… a means for improvement on previous biomimetic theranostics.
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DEVELOPMENT AND CHARACTERIZATION OF NOVEL MONOCLONAL ANTIBODIES TARGETING CARBOHYDRATE ANTIGENS IN CANCER
… and expand opportunities in immunotherapy and theranostics.
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Iron Oxide Nanoparticle Surface Modification: Synthesis and Characterization
… treatment outcomes. This strategy, known as theranostics, focuses on the combination of diagnostic and therapeutic techniques to provide new clinically safe and efficient personalized treatments. The evaluation of different nanomaterials’ properties and their customization for specific …
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CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
… support further investigation of small-peptide theranostics for GBM treatment.</p>
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Design and characterization of plasmonic nanoprobes and interparticle interactions for surface enhanced raman scattering and biomolecular detection
… as an intriguing class of probes in medical theranostics for enabling rapid, sensitive, multiplexing, and point-of-care treatment and diagnosis. One important aspect of these applications is the exploitation of the unique plasmonic properties of certain metal nanoparticles. A key challenge is …
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Inverted micelles: a novel method of theranostic agent encapsulation for enhanced nano-delivery
… for encapsulating and delivering personalized theranostics, customized to match precise therapeutic needs.
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Engineered Polydopamine Nanocarriers for Biomedical Applications
… therapeutics, drug delivery systems, and theranostics, which combine therapeutic properties with diagnostic capabilities (Figure 1. 1). In Chapter 2, an antibacterial agent was developed by synthesising a composite of PDA and silver nanoparticles, which was then employed as a …
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Bioinspired functional DNA-nanomaterial conjugates for diagnostic and therapeutic applications
… developing nanomaterials towards better clinical theranostics. First, a general method for quantitative detection of biological substrates in vitro and in vivo has to be proposed. Second, the development of multifunctional nanomaterials for multimodal detection and targeted drug delivery should be …
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Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… on a single nanomedicine platform, referred as theranostics. A stable 19F MRI visible nanoemulsion platform was developed, incorporating celecoxib for COX-2 inhibition and near-infrared fluorescent dye(s) for fluorescence imaging. We hypothesized that inhibition of COX-2 in macrophages using a …
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Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… on a single nanomedicine platform, referred as theranostics. A stable 19F MRI visible nanoemulsion platform was developed, incorporating celecoxib for COX-2 inhibition and near-infrared fluorescent dye(s) for fluorescence imaging. We hypothesized that inhibition of COX-2 in macrophages using a …
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Targeting the Tumor Stroma Using a Monoclonal Antibody Platform Technology
… a platform technology for the development of theranostics targeting FAP that could provide urgently needed therapies and imaging probes for mCRPC patients.
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