Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Theophylline"”.
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Engineering of Inhalation Aerosols Combining Theophylline and Budesonide
In asthma therapy, the use of theophylline to prevent bronchial spasm and glucocorticoids to decrease inflammation is widely indicated. Apart from the acute asthma attack oral theophylline is treated for chronic therapy in order to minimize inflammation and to enhance the efficiency of …
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Pharmacokinetics and Pharmacodynamics of Theophylline in Ruminating Calves
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1987.
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The effects of theophylline on the in vitro respiratory response to hypoxia
… mice is employed to investigate the function of theophylline, a competitive nonselective phophodiesterase inhibitor and adenosine receptor antagonist, on the hypoxic ventilatory response. Brainstem slices are isolated from neonatal mice (4-8 days old) and superfused with artificial cerebrospinal …
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Pharmaceutical analysis and in-vitro aerodynamic characterisation of inhaled theophylline formulations containing drug particles prepared by supercritical fluid processing. Chromatographic, spectroscopic, and thermal analysis of micron-sized theophylline particles prepared by supercritical fluid technology and in-vitro evaluation of their performance as inhaled dry powder formulations.
… aerodynamic performance of a new inhaled theophylline formulation prepared by supercritical fluids technique. For the analysis of the output from the in-vitro tests (and further in-vivo tests) a new, fast, sensitive high performance liquid chromatographic (HPLC) method was developed and …
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Investigation to Identify the Influence of the Surface Energetics of the Dry Powder Formulations of Budesonide and Theophylline on Their Aerodynamic Dose Emission Characteristics.
… a set of single drug and carrier (budesonide or theophylline with either mannitol or lactose) with different levels of surfactant using Inverse Gas Chromatography, and comparing them to their lung deposition performance using a Next Generation Impactor established a relationship between the two. …
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Methods of cellular integration and techniques for improving encapsulated cell viability for the purpose of developing living materials and cell based bio-sensing materials
… strain of bacteria is capable of detecting theophylline, a small organic compound with a chemical structure similar to caffeine, and responding by producing green fluorescent protein (GFP). Cells encapsulated in each gel were subjected to tests that would determine long term viability trends …
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DRUG RELEASE FROM LIQUID FILLED CAPSULE FORMULATIONS
… dissolution medium on the in vitro release of theophylline and ibuprofen from mixtures of PEG with 0 - 10 % w/w PVA, liquid-filled into hard gelatin capsules, have been studied. The release of both drugs was prolonged and controlled by the addition of PVA, particularly in concentrations > 2 % …
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Chemical sensors based on swellable polymer microparticles and molecular imprinted polymers
… that respond to both beta-D-glucopyranose and theophylline molecules by imprinting them in to a lightly cross-linked polymer network prepared by dispersion polymerization in water and acetonitrile, respectively. The molecular imprinting of beta-D-glucopyranose and theophylline was achieved by …
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Chemical sensors based on swellable molecularly imprinted polymer microspheres in a hydrogel
… successfully used to measure norephedrine and theophylline in water and in buffer at neutral pH.</p><p>A new method was developed for preparing swellable norephedrine templated poly (N-isopropylacrylamide-acrylic acid) (poly NIPA-AAc) particles by suspension polymerization in a perfluorocarbon …
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Co-processing of drugs and co-crystal formers and its effect on pharmaceutical dosage-form performance. Co-crystallization of urea/ 2-methoxybenzamide, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid systems: Solid-state characterization including imaging, thermal, X-ray and Raman spectroscopic techniques with subsequent evaluation of tableting behaviour
… malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid co-crystals were prepared using co-grinding- and co-precipitation techniques. In addition, the synthesis of co-crystals through two novel methods has been demonstrated. This includes compaction and convection mixing. The …
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Reduced corticosteroid sensitivity in smokers with asthma: potential mechanisms and treatment
… for this group. The oral bronchodilator theophylline has been suggested as a treatment for corticosteroid insensitivity due to its ability to increase HDAC activity in-vitro. I undertook an exploratory proof of concept clinical trial based on the hypothesis that low dose theophylline …
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Fused deposition modelling three-dimensional printing of solid dosage forms
… of these properties on the FDM 3DP process. Theophylline-loaded filaments, suitable for FDM-3DP, were successfully formulated using three polymeric carriers (Polyvinyl alcohol (PVA), Hydroxypropyl Cellulose (HPC), and Soluplus®). FDM-3DP enabled the manufacture of monolithic and …
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Controlled drug release from oriented biodegradable polymers
… acid) (PLA) films containing curcumin and theophylline as model drugs. Additionally, direction specific drug release was studied from oriented PLA rods containing paracetamol. The films oriented to 2X uniaxial constant width (UCW) or 2X2Y biaxial draw ratio showed retardation of drug …
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Investigations of Pharmacokinetic Challenges in Premature Infants
… simulation (M&S) approach was explored in the theophylline population pharmacokinetic (PopPK) study in order to get an appropriate study design with the optimized sample size. Finally, PopPK of caffeine was investigated in premature infants using clinical data. Optimized dosing regimens were …
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Estudos de modelagem molecular da piperina e CYP3A4 : a influência na biodisponibilidade de fármacos
… the enhance in bioavailability of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding energy of - …
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Performance-Based Quality Specifications: The Link between Product Development and Clinical Outcomes
… trials were conducted using the model drug, theophylline, for which data and models could be acquired from the literature. Where comprehensive data were unavailable (e.g., production variability statistics), initial estimates were acquired via laboratory-scale experiments. Model asthmatic …
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Aspects of bioorganic chemistry - a). Development of caffeine-aptamer for coffee decaffeination; b). Study of 1,8-naphthalimide derivatives as fluorescent probes; c). Encapsulation of DNA by silica nanoparticles
… caffeine from coffee brew. Toward this goal, theophylline carboxylic acid and caffeine carboxylic acid were synthesized, and immobilized to ω-aminohexyl–agarose. The immobilized compounds were used for aptamer selection. The ionic composition of medium roast coffee grinds was determined by …
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