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Showing 1 to 2 of 2 for “"Theonellamide C"”.
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Synthetic efforts toward the eastern hemisphere of theonellamide C
The theonellamides (TNMs) A-F are bicyclic dodecapeptides isolated from marine sponges of the genus Theonella and were shown to display potent antifungal activity. Despite considerable synthetic effort to produce TNM F by the Shioiri group in the early 1990s, a total synthesis of a TNM has yet to …
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Synthetic Routes to Therapeutic Agents Via Masked Functionalities: From Orthogonal Peptide Crosslink to Photothermal Cancer Prodrug
The theonellamides are a family of compounds distinguished by their crosslinking ô-histidinoalanine (ô-HAL) residue. Part one of this dissertation details the synthesis of an orthogonally protected ô-HAL building block that will be incorporated into a total synthesis of theonellamide C. Selective …