Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2743 for “"The Host"”.
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Genotoxic remodeling of the host epithelium
… a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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Substance P And The Host Immune Response
<p>This body of work examined the mechanism by which SP regulates host immunity, specifically, its control of growth factors and TLR expression in the P. aeruginosa-infected cornea. The role of mTOR and VIP in corneal infection and inflammation also was tested.</p> <p>SP has a dual role in …
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Investigating the host-microbe dialogue in aging
This thesis aimed to investigate the role of the gut microbiota and their associated functionality in the context of aging and life stage related diseases. The focus was maintained on key inter-kingdom signalling molecules, host produced but bacterially modified Bile acids (BAs) and on dietary …
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Gene expression during the host-bacteria interaction
The gene expression profile of both host and pathogen can be altered dramatically upon their interaction. This response is shaped by the co-evolutionary arms race where the host seeks to detect and counter the invading pathogen, whilst the pathogen aims to evade this response and modify the host to …
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The Host Response to Venezuelan Equine Encephalitis Virus
Viruses are currently the most common cause of encephalitis. Arboviruses in the Alphavirus genus in the family Togaviridae contain multiple viruses capable of causing human encephalitis. Of these, VEEV represents the most significant human pathogen. However, no licensed vaccines or therapeutics are …
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Understanding the Host Cellular Response to Astrovirus Infection
… single-stranded RNA virus that infects the small intestine and causes gastrointestinal disease in most hosts. However, in immunocompromised patients, astrovirus can infect the brain, causing encephalitis and death. Here, we characterize astrovirus induction of replication organelles and …
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Evolution of targets at the host-pathogen interface
… 1: Introduction <br>Background information of the origin, pathophysiology, and therapeutic options for both the bacterial pathogen Mycobacterium tuberculosis (Mtb) and betacoronaviruses – the Severe Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in particular – is presented. Chapter 2: …
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Silencing the host : the role of intronic microRNAs
Fifteen years ago lin-4 was reported to be the first endogenous small non-coding, but interfering RNA structure involved in developmental timing in C. elegans. First thought not, or only rarely, to occur in mammals, microRNAs are now among the major players in up-to-date genomic research. The …
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The host response to cancer and cancer-associated cachexia
… impact on prognosis and quality of life, and the consequent poor tolerance/response to treatment, cachexia is a major global public health burden. In the first chapter of my thesis, I analyse the usage of ketogenic diets (KD) containing high levels of fats as adjuvant therapies in end-stages …
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Mycobacterial strain diversity : impact on the host immune response
Bibliography: p. 169-207.
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Metal sequestration of the host-defense protein human calprotectin
… (Mn), iron (Fe), and zinc (Zn) to colonize the mammalian host and to cause disease. As part of the first line of defense against pathogenic infection, the host innate immune response deploys a number of metal-chelating host-defense factors that restrict the access of nutrient metals from …
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Defining the Host Genetic Control of the Barley Rhizosphere Microbiota
… amid climatic modifications is one of the major challenges facing agriculture in the XXIst century. Crucially, over the course of the next 30 years, innovative strategies are required to tackle this challenge and ensure a sustainable and safe access to food resources to a global …
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The Host Galaxies of Luminous Reddened Quasars at z~2
The work in this thesis concerns the host galaxies of a class of luminous, yet heavily-obscured, quasars at z$\sim$2 - a peak epoch of both star formation and black hole accretion. Here, we seek to characterise the star-forming properties of these obscured quasars to improve our understanding of …
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Investigations on the host-parasite interface of a mycoparasite system /
The cell wall composition of Choanephora cucur - bitarum and the host-parasite interface, after infection with Piptocephalis virginiana , were examined in detail. The cell walls of C_. cucurbitarum were determined to be composed of chitin (17%), chitosan (28.4%), neutral sugars (7.2%),uronic acid …
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Ironing Out the Host-fungal Interaction in Airway Epithelial Cells
… and most commonly invasive aspergillosis. The airway epithelium, a protective barrier, is the first anatomical site to interact with A. fumigatus. Although this host-fungal interaction is often asymptomatic for immunocompetent individuals, for immunocompromised persons, due to a weakened …
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Studies of the host-microbe relationship in aquaculture-raised animals
… important industry. A major focus area for the aquaculture field is related to sustainability by ensuring the health and welfare of the aquatic animals. Communities of microorganisms inhabiting the various niches of a given host comprise its microbiome and provide several key health …
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Interactions of Francisella Tularensis With Components of the Host Fibrinolytic System
… commonly referred to as tularemia. Due to the highly infectious nature of the organism, its previous development as a biowarfare agent and its potential use in acts of bioterrorism, this bacterium is listed as a Category A select agent by the Centers for Disease Control and Prevention …
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Macroeconomic effects of foreign direct investment inflows on the host country.
… effects of foreign direct investment inflows on the host country.
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