Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"The Cancer Genome Atlas"”.
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Characterising the Role of the Calcium-dependent Citrullinating Enzyme Peptidyl Arginine Deiminase 2 in Ovarian Cancer
Epithelial ovarian cancer (EOC) represents the fifth most common cause of cancer mortality among women worldwide and accounts for the highest fatalities amongst gynaecological malignancies. The dysregulation of calcium-dependent peptidyl arginine deiminase 2 (PADI2) plays a key role in the …
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Developing Bottom-Up, Integrated Omics Methodologies for Big Data Biomarker Discovery
The availability of highly-distributed computing compliments the proliferation of next generation sequencing (NGS) and genome-wide association studies (GWAS) datasets. These data sets are often complex, poorly annotated or require complex domain knowledge to sensibly manage. These novel datasets …
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Dual Assembly Nanoparticles Achieve Sustained Silencing of Znf304: A Novel Transcription Factor For Β1 Integrin
<p>Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies to this process currently are known. Here, an integrated computational analysis of The Cancer Genome Atlas ovarian cancer dataset coupled with experimental validation identified a novel zinc finger transcriptional …
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Investigation of HPV16-related genomic alterations in cervical squamous cell carcinoma
This study examined the effects of human papillomavirus genomic integration into the host genome on host gene expression in cervical squamous cell carcinoma (CSCC) tumors. The genomic analysis involved clinical and genomics data analysis using bioinformatics and statistical methods. The Cancer …
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Computational Tools and Resources for Pan-Cancer Analyses of Host-Microbe Interactions
<p>The human microbiome is a dynamic, integrated ecosystem that interacts with the host to influence cancer development and progression, as well as affect response to anti-cancer therapies, suggesting opportunities for diagnostic and therapeutic approaches. Many microbe-microbe and host-microbe …
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CancerSubtyper: A Web-Based Deep Learning Platform for Cancer Subtyping Through DNA Methylation Data
Cancer subtyping plays a critical role in understanding tumor heterogeneity, predicting patient outcomes, and guiding personalized therapies. While DNA methylation data offers an informative molecular source for subtyping, leveraging its signals across cohorts remains challenging due to high …
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Diverse Roles Of Nuclear Intermediate Filaments In Proliferating Cells
Embryonic tissues and cancer have in common the fact that they are both highly proliferative tissues rapidly moving through the cell cycle, as opposed to most other differentiated tissues in an adult. DNA damage can arrest some embryonic cells but genetic instability is a hallmark of cancer. This …
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Using Tumour Evolution to Understand the Epigenetic and Transcriptional Adaptations of Cancer to Host Immunity
Immunoediting describes the process in tumour development whereby tumours evolve to avoid the immune system. The relevance of immunoediting in carcinogenesis, metastasis and immunotherapy resistance makes understanding the mechanisms of immunoediting essential in informing cancer therapy and …
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Identification of epigenetically dysregulated genes in tumours that metastasise to the brain
Tumour metastasis to the brain is a common and deadly development in certain cancers; 18-30% of breast tumours metastasise to the brain. The contribution that gene silencing through epigenetic mechanisms plays in metastasis to the brain is not well understood. To identify epigenetic drivers of …
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Biologically Interpretable, Integrative Deep Learning for Cancer Survival Analysis
… associated to patients' survival time at the cellular and molecular level is critical not only for developing new treatments for patients but also for accurate survival prediction. However, highly nonlinear and high-dimension, low-sample size (HDLSS) data cause computational challenges in …
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IDENTIFYING EARLY STEPS IN THE DEVELOPMENT OF HBV ASSOCIATED HCC
The hepatitis B virus (HBV), chronically infecting ~360 million people worldwide, accounts for over half of the cases of hepatocellular carcinoma (HCC) and contributes to over 650,000 deaths per year making HCC is the fifth most common and second most deadly form of cancer.1-3 Many genes …
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Insertionally polymorphic human endogenous retroviruses and their potential role in cancer
… retroviruses, HERV-K(HML-2) was investigated. The family is the youngest endogenous retrovirus family known in humans, with some of its members being insertionally polymorphic in modern human populations. There have been numerous reports of HERV-K(HML-2) members being present in cancer samples. …
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Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer
<p>Lung cancer remains the leading cause of cancer related deaths worldwide, reportedly contributing to 1.8 million of the 10.0 million mortalities documented in the year 2020. Although advancements have been made in therapeutics and diagnostic methods, formulation of effective treatments and …
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Multimodal data analysis applied to a medical setting
Complex diseases, such as cancer, have traditionally been studied using genetic data, or images alone. To understand the biology of such diseases, joint analysis of multiple data modalities could provide interesting insights. We propose the use of canonical correlation analysis (CCA) as a …
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Statistical Modeling Approaches For The Inference of Cancer Mechanisms
<p>The aim of this study was to explore the potential of integrating multi-platform genomic datasets to improve our understanding of the biological mechanisms behind cancer. By merging clinical outcomes with the data obtained from multi-platform genomic studies, we can gain insight into the …
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The Immune Microenvironment of Microsatellite Instable Endometrial Cancer
… patients with advanced and recurrent endometrial cancer (EC) should standard chemotherapy fail. Recent studies in other tumor types have shown that tumors with high microsatellite instability (MSI-H) have increased immunogenicity and response to immunotherapy treatments compared to microsatellite …
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Structural and Functional Studies of ASCC1 in DNA and RNA Alkylation Damage Response
… from environmental, endogenous, and certain chemotherapeutic sources constantly challenge cellular nucleic acids. Repairing the damage caused by alkylation is necessary for maintaining genomic stability. ALKB family Human Homolog ALKBH3 plays a key in repairing alkylated damages in DNA and RNA …
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Deconvolute Brain Tumor Genomic Alterations Based On Dna Methylation
… tumors, particularly malignant gliomas. However, the association between epigenetic signature and genetic alterations is poorly understood. For example, mutation of isocitrate dehydrogenase (<em>IDH</em>) is associated with genome-wide hypermethylation of CpG islands in gliomas. But other …
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Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
… campioni di adenocarcinoma del colon (COAD) del The Cancer Genome Atlas (TCGA) e nei modelli cellulari. La caratterizzazione molecolare delle linee cellulari di carcinoma colorettale è stata eseguita utilizzando piattaforma ad alta risoluzione SNP array 6.0. Gli effetti antitumorali del …
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REDEFINING PROMOTER DNA METHYLATION CHANGE IN CANCER
… has been recognized for decades as one of the major mechanisms of epigenetic gene regulation and has consistently been found to be perturbed during cancer development. However, among the many genomic regions that have been found to display altered methylation in different cancer types, …
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