Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Thalidomide"”.
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Thalidomide-induced teratogenesis in gray short-tailed opossums (Monodelphis domestica)
From 1957 to 1962, Thalidomide was prescribed to pregnant women as an antiemetic and was later discovered to cause serious birth defects. Thalidomide is currently being prescribed to treat erythema nodosum leprosum and multiple melanoma, and is being considered for other anti-angiogenic …
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Investigating biomarkers in clinical samples that are predictive of response in multiple myeloma
… both genotypically and phenotypically. Thalidomide is an effective treatment for multiple myeloma. However, some patients fail to respond to thalidomide treatment and identifying this cohort may provide better individualized treatment. Proteomic analysis was performed on serum samples …
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The Combined Effect of In-Situ Tumor and Irradiation on Peritumoral Brain Vasculature
… have also used this model to test the effect of thalidomide on limiting radiation toxicity to the normal tissue while not interfering with radiation efficacy.</p> <p><strong> </strong>Intravital microscopy was used in combination with a cranial window brain tumor model to assess the effect of …
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Development of a new screening assay to identify proteratogenic compounds using Zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT)
… Cyclophosphamide, ethanol, benzo[a]pyrene and thalidomide were used as test materials to assess the efficiency of this assay. Briefly, the zebrafish embryos were co-cultured at 2 hpf (hours post fertilization) with the test material at varying concentrations, mammalian liver microsomes from …
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Development and application of novel analytical methods for molecularly targeted cancer therapeutics
… mechanisms, and 2) the multiple myeloma drug thalidomide as a pilot study to identify potential correlations between serum drug levels and toxicity/efficacy. Acquired resistance to chemotherapeutics through the over-expression of ABC transport proteins has presented a significant clinical …
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Immunotherapy in multiple myeloma
… short period of time following autologous HSCT. Thalidomide therapy of patients with relapsed disease was associated with an increase in BmDC1 and BpDC numbers. Monocytes, mobilised at the time of stem cell collection, were used to produce mature DC (matDC) from MM patients and normal donors …
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Sunitinib-Induced Cardiotoxicity Exposes Microvascular and Metabolic Derangements In The Failing Heart
… of sunitinib. Furthermore, co-treatment with thalidomide can protect from sunitinib-induced cardiac dysfunction without altering the antitumor effect of the drug. Examination of sunitinib-induced metabolic changes revealed that sunitinib treatment leads to a profound increase in glucose uptake …
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The Association Between Cancer-Related-Fatigue, Response to Fatigue Treatment, and Cytokines and Their Receptors, In Patients With Advanced Cancer
… Controlled Trials, of anti-inflammatory agents (Thalidomide and Dexamethasone) for CRF. Responders showed improvement in FACIT-F subscale at the end of study (Day 15). Baseline patient characteristics and symptoms were assessed by FACIT-F, ESAS; serum cytokines [IL-1β and receptor antagonist …
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Biochemical investigation of phosphodiesterase type IV post-translational modification, cellular localisation and interaction with associated binding proteins
… PKC pathways. Further, the Immunomodulatory drug Thalidomide® also inhibits foci formation. PDE4 isoforms have isoforms specific N-terminal regions, which play a crucial role in sub-cellular localisation and protein-protein interactions. It is shown here that PDE4D5 interacts with a novel RhoGAP …
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Probing the mechanism of the asymmetric alkylation of pseudoephedrine amides
… consequences as in the notorious example of the thalidomide drug. A widely used method to synthesize enantiomerically pure compounds is to utilise a chiral auxiliary. A.G. Myers developed a synthetic route using pseudoephedrine, which is an efficient auxiliary to produce enantiomeric enriched …
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Targeting Protein Degradation to Uncover Novel Oncoprotein Drivers of Acute Leukemia
… of these MGs. Among these compounds, SJ6986, a thalidomide-driven sulfonamide showed potent cytotoxicity in over 10 ALL cell lines tested in vitro. TMT-MS proteomic analyses identified GSPT1/2 as the primary targets for this compound with high selectivity. We next tested SJ6986 activity in a …