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Showing 1 to 2 of 2 for “"ThT-assay"”.
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Protein stability: Impact of formulation excipients and manufacturing processes in protein-based pharmaceuticals
… dynamic light scattering (DLS). Thioflavin T assay and turbidimetry analysis were used as complementary studies. In protein-based freeze dried formulations, at accelerated storage conditions, the presence of aggregates were studied in samples containing arginine or lysine using ThT assay and …
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Studies of the Physical Stability of GLP-1 & Chemically Modified Forms of GLP-1
… AFM, SEM, far-UV CD, FT-IR, 𝜆max, ANS, ex situ ThT and DLS, were employed to probe the structure, size and properties of species in solution during aggregation. The influence of amidation at the C-terminus of GLP-1 on physical stability was assessed and significant differences to GLP-1 were …