Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"ThDP"”.
-
Investigation of the Evolutionary Aspects of Thiamin Diphosphate-Dependent Decarboxylases
Thiamin diphosphate (ThDP)-dependent enzymes catalyze a wide range of reactions including the oxidative and nonoxidative decarboxylation of 2-keto acids, carboligation reactions, the cleavage of C-C bonds, and the formation of C-S, C-N, and C-O bonds. Surprisingly, given this diversity, all …
-
Insights into structure, dynamics of thioredoxin reassembly and dynein light chain 8 and ionization states of thiamin cofactor by MAS NMR spectroscopy
… states of thiamin diphosphate cofactor (ThDP) in large protein, ThDP-dependent family of enzymes are probed using MAS NMR spectroscopy, described in Chapters 5 and 6.
-
The design and synthesis of a novel thiamine cofactor for potential biocatalysis
… in 2006. Figure 1: 1,4 – disubstituted triazole ThDP Synthesis of a cofactor that could theoretically carry out alternative reaction pathways and invoke novel enzyme-substrate pathways, whilst regenerating the cofactor in situ was envisaged (figure 2). Structural analogues of this coenzyme could …
-
Microstructure and tensile performance evolution during Titanium - 6 Aluminium - 4 Vanadium (Ti-6Al-4V) temporary hydrogen treatment
… and thermohydrogen and deformation processing (THDP). Cast Ti-6Al-4V was hydrogenated to 20 at.%H and subsequently dehydrogenated at 675⁰C (HDH 675), 700⁰C (HDH 700), 725⁰C (HDH 725) and 750⁰C (HDH 750). Hydrogenated Ti-6Al-4V was solution treated (at 900⁰C), aged (at 580⁰C) and dehydrogenated …
-
OPPORTUNITIES AND CHALLENGES OF BIOCATALYSIS IN PHARMACEUTICAL SCIENCES: DEVELOPING TAILORED BIOCATALYSTS FOR SYNTHETIC APPLICATIONS
… First, a biocatalytic cascade combining the ThDP-dependent enzyme Ao:DCPIP OR with stereoselective ATAs was established for the synthesis of (1S)-nor(pseudo)ephedrine analogues. The cascade was further optimized by covalent enzyme immobilization, enabling enhanced stability, efficient reuse, …
-
Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex: e1 and e2 substrate specificty, e1 carboligase activity, and e2 interchain succinyl transfer
… is likely between two different E2o subunits. ThDP-dependent enzymes have the potential to be used for chemical synthesis. These enzymes share a common feature in that they catalyze carboligase reactions. E1o catalyzed carboligation products with a variety of substrates and acceptors that vary …