Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Th2 cytokines"”.
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The regulation of CXCR4 and CCR5 expression on human monocytes by Th1 and Th2 cytokines: Functional implications on cell migration and HIV infection.
The role of Th1 (IL,-2 and IFN-gamma) and Th2 (IL-4 and IL-13) cytokines in the regulation of CXCR4 and CCR5 expression by monocytes, and the functional implications of Th1 and Th2 cytokine induced alterations in chemokine receptor expression on chemotaxis and HIV infection, are poorly understood …
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Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis
… IBD, in that it is driven by a T helper type 2 (Th2) immune response. Oxazolone-induced colitis is a mouse model resembling UC presenting with inflammation limited to the distal colon and mixed neutrophil/lymphocyte infiltration in the superficial layer of the mucosa. The Th2 cytokines …
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Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice
… the importance of CD28 in initiating protective Th2 immunity against both primary and secondary infections with N. brasiliensis. Our findings demonstrate that CD28 is required for initiation of protective Th2 immunity against primary infection with N. brasiliensis. Furthermore, the absence of …
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Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3-dependent Pathway
… in either connective tissue or mucosa. Th2 cytokines have been implicated in the regulation of mast cell development and subsequent function. Mast cells have also been shown to be essential players in many Th2 immune responses. In the following study we investigate the effects of the Th2 …
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Differential gene expression and immune regulatory mechanisms in parasite-resistant hair and susceptible wool sheep infected with the parasitic nematode, Haemonchus contortus
… using real-time RT-PCR and included TH1 and TH2 cytokines, cytokine receptors, and IgE. Parasite infection leads to increased expression of IL-13 and IgE in both tissues and breeds when compared to control animals. Breed comparison of gene expression shows resistant hair sheep produce a …
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INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… investigating the HIV reservoir, circulating Th1/Th2 cytokines, gut integrity, and microbial translocation in individuals with PHI and chronic HIV infection (CHI) before and after cART initiation; (2) assessing immune parameters, gut barrier dysfunction, and mitochondrial stress in PLWH switching …
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Immune related gene expression of parasite-resistant sheep during a Haemonchus contortus infection
… and inflammation, but no expression of key Th2 cytokines. Hair sheep expressed genes more closely related to Th2 immune responses. Experiment 2 assigned 12 St. Croix hair lambs and 12 Suffolk crossbred wool lambs into two groups: naive control and day 10 challenge. No genes were …
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The association between psychosocial factors, angiogenesis & host Th1/Th2 immune response in patients with colorectal cancer
… host immune response against the tumour. The Th1/Th2 cytokine profile plays an important part in determining how the immune system operates and modulation of this has potential therapeutic value.The efficacy of treatment for colorectal cancer is based on four primary end points: tumour response …
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
… which induced colon cancer cell migration, and Th2 cytokines (IL-4, IL-10) to maintain a tumoral immunosuppressive environment. Remodelling of extracellular matrix (ECM) occurs in CRC. CD47 binding to α2β1 integrin could regulate cyclooxygenase-2 expression and cell migration on collagen I …
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
… more efficient in producing th1 and th2 cytokines and show faster and CD28 co-stimulation independent cell cycle progression.Interestingly PKB tg T cells are resistant to CsA treatment in proliferation and cytokine production.Further analysis show PKB tg CD4+ T cells have a …
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Mast cells in gastrointestinal helminth infection
Helper T cells type 2 (Th2)play an essential role in host protective responses against the gastrointestinal (GI) nematode parasite, Trichinella spiralis. It is believed that mast cell recruitment and activation may be associated with parasite expulsion from mice. In the current study, we …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… significant upregulation of pro-inflammatory cytokines such as Il1β, Cxcl1, and Ccl2. This animal model was thus validated in studying colitis progression and highlighted the potential of dietary interventions, such as the modified (MOD) diet, to alleviate inflammation. Subsequent research …
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Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans
… At early time point, there was upregulation of Th2 cytokines IL-4, IL-10, and IL-13 by both plasmacytoid and myeloid DCs in the presence of hyphae and PGE2. At later time points, fungal or host PGE2 treatment resulted in decreased Th1 cytokine production (IL-12 and IL-6) and slightly increased …
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… M1 macrophages promote inflammation through cytokines such as IL-1β, IL-6, and TNF-α, whereas alternatively activated M2 macrophages support immune regulation and tissue repair processes. However, in LN, increased infiltration of CD163⁺ M2 macrophages is associated with disease severity and …
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The role of T cell Immunoglobulin Mucin domain in Herpes Simplex Virus-induced Behçet’s Disease mouse model
… cell surface markers for T helper type (Th)1 and Th2 T cells. TIM-1 plays an important role in the regulation of immune responses and the development of autoimmune diseases. TIM-4 is a natural ligand of TIM-1, and interaction of TIM-1 and TIM-4 is involved in the regulation of Th cell responses …
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Investigations into the Biological Roles of the E3 ligase Ariadne 2/TRIAD1
… serum immunoglobulin levels and pro-inflammatory cytokines, and dramatic heterogeneous cellular organ infiltration, consisting mainly of T cells. T cell homeostasis is also altered, as seen by increased activated and ‘memory-like’ T cells, elevated TH1 and TH2 cytokines, increased regulatory T …
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CD23's Role as a Negative Regulator of Allergic Disease: in vivo Effects of Murine CD23 Destabilization and Allelic Mutations
… lung inflammation and reduced levels of IgE and Th2 cytokines and chemokines. Overall, the data provide a direct demonstration for CD23's role in regulating IgE production in vivo and suggest that therapies aimed at stabilizing cell surface CD23 would inhibit proteolysis and increase surface …
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Role of Allergic Conjunctivitis in Inducing Corneal Transplant Rejection
… Tregs that support corneal allograft survival. Th2 cytokines, namely IL-4, generated during allergic conjunctivitis, render effector cells resistant to the suppressive ability of Tregs. Furthermore, allergic conjunctivitis did not exacerbate corneal allograft rejection unless the host’s effector …
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Role of T cells and cytokines in the induction of tolerance to renal tubular antigen in active Heymann nephritis
… or complement. Increased mRNA expression of the Th2 cytokines IL-4 and IL-5 was detected in draining lymph nodes. These findings suggest that immune deviation to a Th2 response reduces glomerular injury in HN. Second, the role of CD4+ T cells in immune tolerance was examined. Rats were given RTA …
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Investigation the immunological response elicited to the gastrointestinal nematode pinworm (Syphacia obvelata)
… Infection with S. obvelata induced a transient Th2-type immune response with elevated cytokine production and parasite-specific IgG1. In contrast, HALB/c mice, deficient for IL-13, lL-4/13 or IL-4Ra showed chronic disease with more than 100-fold higher parasite burden, increased IFN-y …
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