Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 35 for “"Th2 Cells"”.
-
Regulation and Effector Function of TH1 and TH2 Cells in Immunity to Bordetella Pertussis
… or Pa, revealing roles for both antibody and T-cells in protection against B. p ertu ssis. It has been demonstrated that children still appear to be protected against infection, despite a rapid decline in antibody levels after vaccination. In the murine model, antibody levels quickly decline …
-
Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
Antigen-specific Th2 cells are central to the pathogenesis of asthma and other allergic diseases. Th2 cells secrete the cytokines IL-4, IL-5 and IL-13, responsible for many of the features of allergic inflammation such as eosinophilia, IgE production and mucus hypersecretion. Cysteinyl leukotrienes …
-
The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells
… responses is coordinated by CD4+ T-helper (Th) cells. Depending on the cytokine environment, Th progenitor (Thp) cells differentiate into three functionally different effector subsets. T-helper-1 (Th1) cells which mediate cell-mediated immunity, T-helper-2 (Th2) which orchestrates humoral …
-
Modelling and Investigation of Drug and Immune Therapies for Cancer
… literature supporting the hypothesis that immune cells affect the tumour cells. For example, Mattes et al, show that the tumour (i.e., B16-OVA melanoma) is eliminated by Th1 cells, but Th2 cells reduce the size of tu- mour (i.e., not eliminate the tumour cells). However, Xie et al show that the …
-
Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
… a role for IFN-α/β in the regulation of Th2 development as well as memory Th2 cell function. The Th2 master transcription factor GATA3, promotes its own expression through a positive regulatory loop, uncoupling the cell from the requirement of IL-4 signaling. IFN-α/β inhibits this process …
-
Inhibition of IFN-[gamma] promoter function by site-specific methylation
When they become activated, naive helper T cells are able to polarize into either THI cells or TH2 cells. Development of naive CD4+ T cells into TH1 cells is characterized by the expression of IFN-y and the silencing of IL-4, while development into TH2 cells is characterized by expression of IL-4 …
-
Transcriptomic phenotyping of the macrophage response to filarial nematode infection
… things, by IL-4 and IL-13 production from CD4* Th2 cells. IL-4 and IL-13 induce alternatively activated macrophages (AAMΦ) via their action on the IL-4Rα receptor subunit. AAMΦ are also implicated in numerous other diseases such as fibrosis, allergy, cancer and diabetes.
-
Adaptive Immunity in Cardiovascular Disease
… and stroke, both affecting millions worldwide. T-cells and antibodies have been implicated in atherosclerosis. This thesis contains studies on CD4+ helper subsets and studies on antibodies against methylglyoxal-modified apolipoprotein B100 (MGO-ApoB100). In the prospective Malmö Diet and Cancer …
-
The Role of NDFIP1 in T Cell Tolerance
… mechanisms to contain the activity of immune cells are necessary to prevent immune responses against non-pathogenic antigens and the severe immunopathology that would otherwise result. In T cells, these mechanisms are termed T cell tolerance. T cell tolerance is defined as the collection of T …
-
Parasite interactions with dendritic cells and macrophages: Implications for cutaneous Leishmaniasis caused by Leishmania amazonensis
… studies have established the model of Th1-Th2 paradigm: gamma interferon (IFN-g)-secreting Th1 cells protect the host from developing progressive diseases, while interleukin (IL)-4-producing Th2 cells drive the disease pathogenesis. Focused on L. amazonensis infection in mice, this …
-
Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
… the differentiation of germinal center (GC) B cells and follicular T helper (TFH) cells. The interaction of TFH and GC B cells is necessary for the development of high affinity antibodies specific for an invading pathogen. Germline BCL6-deficient mouse models limit our ability to study BCL6 …
-
Transcriptional Regulation of the Inducible Costimulator (ICOS) in T Cells
… expression during early activation of CD4+ T cells by T cell receptor and CD28 co-engagement as well as during the differentiation of these cells into Th1 and Th2 lineages. In recently activated T cells, our data suggests that the Fyn-calcineurin-NFATc2 and MEK2-ERK1/2 signaling axes cooperate …
-
Prolonged T – DC macro-clustering within lymph node microenvironments initiates Th2 differentiation in a site-specific manner
T helper 2 (Th2) responses protect against pathogens while also driving allergic inflammation, yet how large-scale Th2 responses are generated in tissue context remains unclear. Here, we used quantitative imaging to investigate early Th2 differentiation within lymph nodes (LNs) following cutaneous …
-
The Effect of Tim-3-Ig on Tumor Growth
… be specifically expressed on CD4+ Th1 and not on Th2 cells. Tim-3 negatively regulates Th1 immunity and induces tolerance, but it's function has not been clarified in tumor immunity. To explore the effect of Tim pathway blockade on tumor growth using Tim-3-Ig fusion protein, two approaches were …
-
THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
… transferring ovalbumin (OVA) specific CD4+ T cells into normal BALB/c mice which then inhaled OVA for 7 days. Mice were treated daily with either CB2 compound or vehicle, and the anti-inflammatory effect of the CB2 agonist was examined by monitoring the effect of the treatment on the level of …
-
THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
… transferring ovalbumin (OVA) specific CD4+ T cells into normal BALB/c mice which then inhaled OVA for 7 days. Mice were treated daily with either CB2 compound or vehicle, and the anti-inflammatory effect of the CB2 agonist was examined by monitoring the effect of the treatment on the level of …
-
The roles of Cabin1 and Left1 in T cell development
… changes in immunoglobulin class switching as B cells from mutant mice switched to IgG 1 at the same frequency as wildtype B cells in vitro in the presence of IL-4. However, in response to anti-CD3 stimulation, mutant T cells expressed significantly higher levels of IL-2, IL-4, IL-9, IL-13, and …
-
The role of lactate in CD4+ T cell differentiation and function
… been already studied in the context of CD4+ T cells differentiation, nothing was known about the less abundant D- enantiomeric form until now. By supplementing in vitro cultures of Th1 and Th2 cells with exogenous D- or L-lactate, we describe for the first time D-lactate’s enormous potential to …
-
Investigating The Possible Role Of Regulatory T Cells In Suppressing DTwP And Measles-Vaccine Induced Responses In 9 Month-Old Gambian Infants
… by limited Th1 immunity and skewed towards Th2 and immunoregulatory responses. This results in high susceptibility to infections and impaired responses to vaccines. Regulatory T cells (Tregs) control pro-inflammatory responses and are therefore important in maintaining a fine balance of …
-
Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screens
T helper-2 (TH2) and type 2 innate lymphoid cells (ILC2s) play important roles in parasite expulsion, wound healing and allergic diseases through the expression of type 2 cytokines including IL-4, IL-5 and IL-13. Central to lymphocyte function are molecules required for differentiation and …
Page 1 of 2