Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Th17 cell"”.
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Mechanically-Induced Osteocyte-Th17-Cell Signaling and Osteoclastogenesis
… of bone resorbing osteoclasts. However, the extracellular signals involved in the initiation of targeted bone remodeling are still unknown. While apoptosis is commonly referred to as a non-inflammatory event, inflammatory cytokines have been shown to be mediators of the bone remodeling process. To …
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Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases
… genetic and other factors. T helper 17 (Th17) cells play a critical role in the immune pathology. Th17 cells are a group of specialized CD4+ T cells with potential pro-inflammatory function which are different from other T cells such as T helper 1 (Th1) cells or T helper 2 (Th2) cells. …
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Th17 Cell Pathogenicity Promoted by Integrin α3 During Autoimmune Neuroinflammation
… (CNS) is affected by chronic inflammation, and Th17 cells are critical mediators of disease pathogenesis. While targeting leukocyte trafficking is effective in treating autoimmunity, there are currently no therapeutic interventions that specifically block encephalitogenic Th17 cell migration. …
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SELECTIVE CB2 RECEPTOR ACTIVATION AMELIORATES INFLAMMATION IN CENTRAL NERVOUS SYSTEM BY REDUCING TH17 CELL DIFFERENTIATION AND IMMUNE CELL ACCUMULATION.
… receptor expressed primarily on hematopoietic cells and activated microglia, mediates the immunoregulatory functions of cannabinoids. The involvement of CB2 in central nervous inflammation has been demonstrated by using both endogenous and exogenous ligands. We showed previously that CB2 …
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Effect of progestin-based hormonal contraceptives on genital inflammation and Th17 cell activation in adolescents at high risk for HIV infection
… immaturity may increase activation of CD4+ T cells in the female reproductive tract (FRT), which are target cells for HIV infection. NuvaRing, also a long-acting progestin-containing contraceptive albeit topical, has recently been introduced to South Africa, and may offer an improved safety …
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Regulation of Adaptive and Innate Immunity by the Circadian Transcription Factor NFIL3
… which has been shown to be mediated by an intracellular timing system called the circadian clock. However, little is known about whether and how the day-night cycle and the circadian clock influence host immunity. Here, I show that the circadian transcription factor NFIL3 is critical for both …
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Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract
T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute …
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… barrier, commensal bacteria, and immune cells, along with the interactions between the three players maintain a toleranic environment to food and microbiota. Conversely, when a dysregulated interaction occurs in genetically susceptible individuals, the homeostasis breaks down and chronic …
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… barrier, commensal bacteria, and immune cells, along with the interactions between the three players maintain a toleranic environment to food and microbiota. Conversely, when a dysregulated interaction occurs in genetically susceptible individuals, the homeostasis breaks down and chronic …
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HP Turns 17: T helper 17 cell response during hypersensitivity pneumonitis (HP) and factors controlling it
… formation, and fibrosis. Since HP is a T cell-mediated disease, it is important to determine the type of T cell response associated with granuloma formation and the factors that control this response. We hypothesized that HP is associated with a predominant Th17 cell response where both …
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Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
Immune cells have evolved to respond to external danger signals and to incorporate information about environmental cues to adapt their differentiation and effector function. Because of this, it is important that immune cells are studied in the context of their surroundings. In this thesis, I …
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Alterations in endometrial immune cell populations affect endometrial cell functions
… as the related infertility. Among other immune cells, the T-helper lymphocytes accumulate in the normal endometrium during the mid- to late-secretory phase of the menstrual cycle and are considered essential for endometrial receptivity. The goal of this project was to 1) study the relationship …
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Epithelial Retinoic Acid Receptor Beta Regulates Serum Amyloid A Expression and Vitamin A-Dependent Intestinal Immunity
… yet little is known about how epithelial cells regulate vitamin A-dependent intestinal immunity. Here I show that epithelial cell expression of the transcription factor retinoic acid receptor β (RARβ) is essential for vitamin A-dependent intestinal immunity. Epithelial RARβ activated …
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The relationship between S. aureus biofilm properties, inflammation, and disease severity in chronic rhinosinusitis
… to the frequency and localisation of key immune cells in corresponding sinonasal mucosa and CRS severity scores. Here, we first found increased S. aureus biofilm metabolic activity, biomass, and exoprotein production in relation to increased disease severity scores with infiltration of …
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… nervous system (CNS), driven by autoreactive T cells that mediate demyelination, axonal loss, and neuroinflammation. Among the pathogenic T helper subsets, Th17 cells are pivotal in MS progression, producing high levels of proinflammatory cytokines such as IL-17. While Interferon-gamma (IFN-γ) …
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The generation and maintenance of T Helper 17 cells in response to bacterial infection
… as sufficient to induce T helper type-17 (TH17) differentiation in vitro, but it is unclear whether these factors are necessary, and if so, what the cellular source of these factors is in the context of a TH17 inducing infection in vivo. Moreover, studies of the TH17 response have focused …
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Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
… by orchestrating the function of other immune cell types. Naïve Th cells can differentiate into different effector subsets that are characterized by their cytokine profile and immune regulatory functions. These subsets include Th1, Th2, Th17, natural and inducible regulatory T cells (nTreg and …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… mucus production and airway remodeling. On the cellular level, pulmonary eosinophilic infiltration and augmented levels of serum IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway following exposure to allergen. It has been proposed that the chronic inflammation and …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… mucus production and airway remodeling. On the cellular level, pulmonary eosinophilic infiltration and augmented levels of serum IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway following exposure to allergen. It has been proposed that the chronic inflammation and …
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The Role of IL-6 in Inflammatory Aortic Aneurysmal Diseases
… tested the relationship of IL-6 signaling with Th17-induced inflammation in the formation of Ang II-induced aortic dissections. We found that Ang II infusion induced aortic dissections and CD4+-interleukin 17A (IL-17A)-expressing, Th17 cell accumulation in C57BL/6 mice. IL-6-deficient mice …
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