Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Th17 Differentiation"”.
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Batf regulates previously unknown AP-1 target genes to control TH17 differentiation
… cells and tissues. IL-17-producing T helper: TH17) cells are a CD4+ T cell subset that coordinates inflammatory responses in host defense but are pathogenic in autoimmunity. To study the role of Batf in T cells, we generated Batf deficient mice by gene targeting. Batf <super>-/-</super> mice …
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… Among the pathogenic T helper subsets, Th17 cells are pivotal in MS progression, producing high levels of proinflammatory cytokines such as IL-17. While Interferon-gamma (IFN-γ) is traditionally seen as proinflammatory, recent findings highlight a paradoxical protective role by …
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Signal specificity amongst STAT1- and STAT3- inducing cytokines in the context of Th17 differentiation
… thesis investigate the conditions which lead to Th17 differentiation and the mechanisms involved in their regulation. Th 17 cells can be obtained in vitro by culturing naive CD4+ T cells with IL-6 and TGF-p under activating conditions. IL-6 was thought to primarily activate the transcription …
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T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation
… a major role in T cell activation, survival, and differentiation; IL1b, in particular, plays a critical role in the differentiation of Th17 lineage cells. Here, I discovered that BCAP functions downstream of IL1R in CD4 T cells and thereby regulates Th17 lineage differentiation and function. …
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Role of Notch Signaling in T Cell Polarization
<p>The differentiation of CD4+ T cells to different effector lineages in response to pathogenic stimuli is the core of the adaptive immune system. One of the effector subsets recently discovered is Thelper 17 (Th17) and it plays a predominant role in autoimmune diseases and inflammatory …
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The generation and maintenance of T Helper 17 cells in response to bacterial infection
… as sufficient to induce T helper type-17 (TH17) differentiation in vitro, but it is unclear whether these factors are necessary, and if so, what the cellular source of these factors is in the context of a TH17 inducing infection in vivo. Moreover, studies of the TH17 response have focused …
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Therapeutic Modulation of Experimental Autoimmune Encephalomyelitis by Gamma Secretase Inhibition
… (γSI) have been shown to suppress TH1 differentiation and reduce the severity of experimental autoimmune encephalomyelitis (EAE), presumably by affecting Notch signaling. To understand the mechanisms through which γSI alter autoimmune T cell responses, we utilized an adoptive transfer …
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MicroRNA and Epigenetic Controls of CD4+ T cells' Activation, Differentiation and Maintenance
… Th1 responses and suppress inducible Treg differentiation. Mechanistically, we found that through targeting Pten, miR-17-92 promotes PI3K activation. Strong TCR-PI3K activation leads to the accumulation of DNMT1, elevated CpG methylation in the foxp3 promoter, and suppression of foxp3 …
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SELECTIVE CB2 RECEPTOR ACTIVATION AMELIORATES INFLAMMATION IN CENTRAL NERVOUS SYSTEM BY REDUCING TH17 CELL DIFFERENTIATION AND IMMUNE CELL ACCUMULATION.
… mechanisms, i.e. an early effect on Th1/Th17 differentiation in peripheral immune organs, and a later effect on the accumulation of pathogenic immune cells in the CNS, associated with reductions in the expression of CNS and T cell chemokine receptors, chemokines and adhesion molecules. …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
… of cytokines that control activation and differentiation of CD4+ T cells. While IL-12 is critical for Th1 lineage development, IL-6 and TGF-b play an important role in differentiation of Th17 cells in vitro. IL-1 has also been implicated in regulating Th17 differentiation. In this …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… (Tfh) lineage while repressing Th1, Th2 and Th17 differentiation. Bcl6-deficient mice develop a spontaneous and severe Th2-type inflammatory disease including myocarditis and pulmonary vasculitis, suggesting a potential role for Bcl6 in Treg cell function. Bcl6-deficient Treg cells are …
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The Effects of Immunomodulatory Agents On the Development of Experimental Autoimmune Encephalomyelitis
… demonstrated that CD4+ T-cell subsets Th1 and Th17, play a significant role in driving disease progression. Current treatment consists of anti-inflammatory or immunosuppressive drugs in an attempt to suppress the production of pro-inflammatory cytokines as well as the activation, expansion, and …
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The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease
… has been reported to be important for human Th17 differentiation in vitro, is critical for the development of this nonconventional T Helper 1 (Th1*)-polarized CD146+CCR5+ conventional T cells (Tconvs) population. Furthermore, we found that ICOS can induce the generation of Th1*-polarized …
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Transdisciplinary Strategies to Study the Mechanisms of CD4+ T cell Differentiation and Heterogeneity
… mechanisms of action underlying the process of differentiation and plasticity of this interesting immune subset are incompletely understood. To gain a better understanding of the CD4+ T cell differentiation and function, here we present an array of different strategies to model and validate CD4+ …
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MicroRNA as Regulator of the Th17 Inflammation in Behcet's disease
… control and 19 healthy controls (HC). To verify Th17 inflammation in BD patients, IL-17 expression was measured using flow cytometry, enzyme-linked immunosorbent assay (ELISA), and real-time polymerase chain reaction (PCR) in peripheral blood mononuclear cells (PBMCs) with or without Th17 …
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T-bet-dependent regulation of T cell responses during Trypanosoma cruzi infection
… However, T-bet was required to suppress the differentiation of Th17 cells and for the expansion of T. cruzi-specific CD8+ T cells. We first sought to determine the cause of reduced numbers of T. cruzi-specific CD8+ T cells in infected T-bet-deficient mice. First, we found that impaired …
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The ontogeny and function of intestinal dendritic cells
… interleukin 17 (IL-17)-secreting helper T (Th17) cell compartment. Mechanistically, in vitro and in vivo experiments suggest that the ability of CD103+CD11b+ intestinal cDCs to induce Th17 differentiation is linked to their capacity to produce IL-6. In contrast, mice lacking IRF4-depending …
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A computational approach to understanding maternal influences on the development of ruminant neonates
… critical for adaptive immunity, including Th17 differentiation, B cell receptor signaling, and PD-1/PD-L1 signaling. Furthermore, CRC lambs showed a more extensive intercellular communication network, particularly in the jejunum, with signaling pathways that suggest enhanced …