Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 162 for “"Th17"”.
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Mechanically-Induced Osteocyte-Th17-Cell Signaling and Osteoclastogenesis
… cytokines (TGF-β1 and IL-6) known to stimulate Th17-cell secretion of osteoclastogenic cytokines (IL-17 and RANKL). Experimental results showed that:|1.MLO-Y4 osteocytes conditioned with high FSS secrete greater TGF-β1 and IL-6 compared to MLO-Y4 osteocytes in static control conditions.|2.T-cell …
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Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases
… genetic and other factors. T helper 17 (Th17) cells play a critical role in the immune pathology. Th17 cells are a group of specialized CD4+ T cells with potential pro-inflammatory function which are different from other T cells such as T helper 1 (Th1) cells or T helper 2 (Th2) cells. …
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Th17 Cell Pathogenicity Promoted by Integrin α3 During Autoimmune Neuroinflammation
… (CNS) is affected by chronic inflammation, and Th17 cells are critical mediators of disease pathogenesis. While targeting leukocyte trafficking is effective in treating autoimmunity, there are currently no therapeutic interventions that specifically block encephalitogenic Th17 cell migration. …
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MicroRNA as Regulator of the Th17 Inflammation in Behcet's disease
… control and 19 healthy controls (HC). To verify Th17 inflammation in BD patients, IL-17 expression was measured using flow cytometry, enzyme-linked immunosorbent assay (ELISA), and real-time polymerase chain reaction (PCR) in peripheral blood mononuclear cells (PBMCs) with or without Th17 …
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Batf regulates previously unknown AP-1 target genes to control TH17 differentiation
… cells and tissues. IL-17-producing T helper: TH17) cells are a CD4+ T cell subset that coordinates inflammatory responses in host defense but are pathogenic in autoimmunity. To study the role of Batf in T cells, we generated Batf deficient mice by gene targeting. Batf <super>-/-</super> mice …
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Identification and Analysis of Omentum Derived Suppressor Cells in Regards to Th17 Inhibition
… properties through suppression of Th1 and Th17, while promoting tolerance through expansion and survival of Tregs. The mechanism of Th17 inhibition relied on IFNɣ-mediated upregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to generation of nitric …
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Expression of Th17 and related cytokines according to clinical activity of Behcet's disease
… discovered, and IL(Interleukin)-17 producing Th17 cells were recognized as novel group of T cells which play a major role in autoimmunity. A recent study has shown elevated production of IL-17, IL-23, and IFN (Interferon)-γ by peripheral blood mononuclear cells (PBMCs) besides increased …
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… Among the pathogenic T helper subsets, Th17 cells are pivotal in MS progression, producing high levels of proinflammatory cytokines such as IL-17. While Interferon-gamma (IFN-γ) is traditionally seen as proinflammatory, recent findings highlight a paradoxical protective role by …
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Recruitment and positioning of regulatory T cells and Th17/Tc17 in inflamed human liver
… be crucial to explore the role of new subset of Th17/Tc17 effector lymphocytes characteristic and their positioning in inflamed liver. This thesis demonstrates the crucial role of chemokine receptors in recruitment and positioning of both intrahepatic regulatory T lymphocytes and IL-17 secreting …
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Signal specificity amongst STAT1- and STAT3- inducing cytokines in the context of Th17 differentiation
… thesis investigate the conditions which lead to Th17 differentiation and the mechanisms involved in their regulation. Th 17 cells can be obtained in vitro by culturing naive CD4+ T cells with IL-6 and TGF-p under activating conditions. IL-6 was thought to primarily activate the transcription …
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The Role of the IL-23/Th17/IL-17 Axis in the Pathophysiology of Endometriosis
… and progression. Notably, the IL-23/Th17/IL-17 axis is significantly altered in EM and associated with disease severity. This is notable as in other chronic inflammatory diseases, IL-23 drives pathogenic Th17 responses, producing IL-17 to exacerbate disease. Th17 cells are also highly …
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MEMORY TH17 CELLS IN THE LUNG DURING SECONDARY BACTERIAL PNEUMONIA FOLLOWING INFLUENZA A VIRUS INFECTION
… strain used in immunization. T-helper type 17 (Th17) cells are increasingly recognized as the key mediators of serotype-independent protection against respiratory bacterial infections. During virus/bacteria co-infection, however, the protective anti-bacterial Th17 responses are inhibited by …
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T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation
… plays a critical role in the differentiation of Th17 lineage cells. Here, I discovered that BCAP functions downstream of IL1R in CD4 T cells and thereby regulates Th17 lineage differentiation and function. IL1b-induced PI3K-Akt-mTOR signaling is compromised in BCAP deficient T cells which leads …
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Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract
… do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well …
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SELECTIVE CB2 RECEPTOR ACTIVATION AMELIORATES INFLAMMATION IN CENTRAL NERVOUS SYSTEM BY REDUCING TH17 CELL DIFFERENTIATION AND IMMUNE CELL ACCUMULATION.
… mechanisms, i.e. an early effect on Th1/Th17 differentiation in peripheral immune organs, and a later effect on the accumulation of pathogenic immune cells in the CNS, associated with reductions in the expression of CNS and T cell chemokine receptors, chemokines and adhesion molecules. …
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… enrichment of pathogenic IFNγ-producing Th17 cells with a concomitant selective and significant enrichment of adherent-invasive E. coli (AIEC) pathotype. Notably, in a recent yet unpublished work, we described a new subset of pathogenic Th17 cells (pTh17), selectively enriched in the gut …
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Effect of progestin-based hormonal contraceptives on genital inflammation and Th17 cell activation in adolescents at high risk for HIV infection
… in terms of HIV risk for young women. Recently, Th17 cells have been found to be disproportionally susceptible to HIV infection compared to the other T helper subsets although the impact of HC use on Th17 cell frequency and activation has not been investigated. Here, the impact of NuvaRing, …
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CONCENTRAÇÕES ELEVADAS DAS CITOCINAS ASSOCIADAS À RESPOSTA Th17 E DESFECHOS DESFAVORÁVEIS EM PACIENTES COM COVID-19 ADMITIDOS À UNIDADE DE TERAPIA INTENSIVA
… outcome of this disease. In this context, the Th17 response has been receiving increasing attention due to its ability to modulate inflammation. A prospective inclusion of 56 COVID-19 patients admitted to the Intensive Care Unit (ICU) of the General Hospital of Vitória da Conquista (HGVC) in …
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