Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Th1 response"”.
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The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis
… cytokine IL-4 has been shown not to increase the TH1 response and resistance to mycobacterial infection. This study asked whether the combined absence of IL-4 and IL3, as compared to IL-4 deficiency only, would increase resistance to an aerogenic Mycobacterium tuberculosis infection. By using IL-4 …
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The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics.
… the C57BL/6 “healer” mice produced a predominant TH1 response, whereas the iLCKcreIL-4Rα-/lox mice and susceptible BALB/c mice produced a TH2 response.
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Clinical and immunological factors associated with post-race upper respiratory tract symptoms (URTS) in Ironman triathletes
… for analysis of cytokines representing mainly a TH1 response (IL-2, and IL-12) (cell mediated immunity) and a TH2 response (IL-4, IL-6, IL-10) (humoral immunity), as well as a saliva sample (for salivary α-amylase, cortisol and IgA concentrations). Collection of blood and saliva samples was …
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The role of dendritic cells in rickettsial infection; initation of early immunity to spotted fever group Rickettsiae
… protective immunity. Previous data imply that Th1 responses are essential for immunity to rickettsiae; however, they do not address mechanisms important in initiating early immunity, particularly those involving dendritic cells. Dendritic cells are instrumental in initiation and control of a …
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Investigating the role of B and T lymphocytes in the course of murine Leishmania Major infection
… infection. It is well documented that T-helper 1(Th1) and T-helper 2 (Th2) responses lead to resistance and susceptiblity to L. major respectively. Recent studies have now shown that B-cells are capable to producing key T-cell differentiating cytokines such as IL-4 and IFN-γ. More specifically, …
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Immunological control of toxoplasma gondii infection
… vaccine induced a greater CD8+ T cell effector response than the adjuvanted peptide vaccine. Successful vaccination is in large part dependent on inducing an appropriate response in the primary host cell populations that consequently influences the development of adaptive immunity. Parasite …
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Maternal Modulation of Neonatal Immunity
… immune system is functionally immature, immune response capabilities are not the same in all newborns. The objective of this thesis was to determine development of immunocompetence and test the hypothesis that activation of maternal inflammatory immunity during pregnancy influences maturation of …
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The Role of Transitional B cells in Kidney Transplantation Tolerance
… This impairment prevented the triggering of the Th1 response by recipient CD4+ T cells and donor-specific antibody production by Plasma cells. Finally, Transitional B cells were the lowest CD4+ T cell- activating cells, compared to Naïve and Memory B cells. This reduced CD4+ T cell activation was …
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The Impact of Vitamin D on the Epidemiology, Pathogenesis, and Treatment of Esophageal Adenocarcinoma
… of GERD, and factors predicting a positive response to treatment is necessary to improve outcomes. Vitamin D is a hormone that acts as an immunomodulator and regulator of cellular proliferation with anticancer properties, and has been implicated in the prevention of some cancers. Its main …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… marked by apoptosis of CD4+ T cells, a weak CD4 Th1 response, and overproduction of TNF-alpha and IL-10. C57BL/6 mice were inoculated intradermally or intraperitoneally with IOE, models that closely reproduce the pathology and immunity associated with tick-transmitted HME, or intraperitoneally …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… of CD1d-restricted cells. The subsequent immune response involves NKT cell proliferation and emission of numerous cytokines, such as interferon-gamma (IFN-gamma) and interleukin-4 (IL-4), resulting in the stimulation of the innate and adaptive immune systems through maturation of APCs, activation …
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Evaluation of the novel P particle vaccine candidate against human norovirus using the gnotobiotic pig challenge model
… to evaluate the protective efficacy and T cell responses induced by P particles and to compare them with prior NoV infection (NoVPO) and VLPs. Gn pigs received 100 µg of P particles (LoPP) or VLPs, 250 µg P particles (HiPP), or adjuvants only intranasally at post-inoculation day (PID) 0, 10, and …
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Investigating the role of IL-4/IL-13 signalling through the IL-4 receptor alpha (IL-4Rα) on keratinocytes in murine models of Leishmania major and Schistosoma mansoni
… important during the parasite life cycle. While Th1 immunity is required to control CL, protection during schistosomiasis requires Th2 immunity. Paradoxically, Th2 characteristic IL-4 secreted early during L. major infection in mice, can drive a Th1 response by instructing dendritic cells to …
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Nod1 and Nod2 in Innate Immune Responses, Adaptive Immunity and Bacterial Infection
… are critical for the induction of inflammatory responses and the generation of a successful adaptive immune response. The array of ligands that these transmembrane proteins recognized mediates defense against bacteria, viruses, fungus and parasites, as well as, possibly, cancerous cells. In …
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Dendritic cells activated by CpG motifs are potent inducers of a Th1 immune response that protects mice against leishmaniasis
… manifestations of leishmaniasis and developed a Th1 immune response. protection was solid and long-lasting, and was also dependent of the via of administration. Whe the mechanism of protection was studied, it was observed that the availability of the cytokine interleukin-12 at the time of …
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Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
… recruitment during HP. During the acute response, TLR2/9−/− mice exposed to SR demonstrated a significant reduction in neutrophil recruitment after a single exposure to SR compared to C57BL/6 mice (WT). The reduction in neutrophils was associated with a reduction in the expression of the …
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Characterization of the alfalfa mosaic virus as expression, presentation, delivery and screening system for potential epitopes derived from the respiratory syncytial virus fusion protein
… tested in mice generated a specific RSV IgG response out of which six covered known neutralization sites and are therefore likely to generate neutralizing abs. Chimeric AlMV particles were also successfully used as presentation, delivery and screening tool for T-helper cell epitopes using …
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Effect of fatty acids and programming on the immune system
… diets differing in FA composition on the recall response in a mouse model of influenza vaccination. A diet rich in salmon oil resulted in enhanced ear swelling (measured after 48 hours) compared with diets rich in linseed oil, sunflower oil or beef tallow, suggesting that long chain n-3 FAs …
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An investigation of the impact of parasitic worm infection on the immunogenicity of candidate HIV vaccines
… to elicit effective antibody and T cell-mediated responses. This is envisaged to be attained through induction of potent T cell-mediated immune responses to control viral replication in the tissues and disease progression as well as a durable antibody immune response which comprises of broadly …
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The impact of malaria on the immunogenicity and efficacy of mycobacterium bovis BCG vaccination against mycobacterium tuberculosis in mice
… the timing of infection on BCG-induced immune responses and efficacy against M. tuberculosis both in vivo by aerosol challenge and ex vivo by Mycobacterial Growth Inhibition Assay (MGIA). Methods and Results To assess the impact of malaria parasite virulence on BCG, wild-type C57BL/6 mice were …