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Showing 1 to 2 of 2 for “"Th1 activation"”.
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Impact Of Cryoablation On Tumor Immunity
… disease is present. To promote the shift to a Th1 phenotype, which is associated with greater anti-tumor activity, CpG was used in combination with cryoablation. This led to significantly elevated IgG2a/IgG1 relative to cryoablation alone and greater tumor protection in wt mice, suggesting Th1 …
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The Suppressive Mechanisms of TIM3 on T Cell Cytokine Production and The Anti-Tumor Effect of TIM3-Pathway Inhibition
… (TIM3) has been shown to be expressed on Th1 cells and negatively regulates these cell functions. TIM3 has been implicated in the Th1-driven pathogenesis of autoimmune disease and the viral infection. However, molecular mechanisms of TIM3 inhibiting Th1 cells and the efficacy of tumor …