Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Th1 Cells"”.
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… barrier, commensal bacteria, and immune cells, along with the interactions between the three players maintain a toleranic environment to food and microbiota. Conversely, when a dysregulated interaction occurs in genetically susceptible individuals, the homeostasis breaks down and chronic …
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… barrier, commensal bacteria, and immune cells, along with the interactions between the three players maintain a toleranic environment to food and microbiota. Conversely, when a dysregulated interaction occurs in genetically susceptible individuals, the homeostasis breaks down and chronic …
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The Role of IkZF Factors in Mediating TH1/TFH Development and Flexibility
The ability of cells within the adaptive immune system to develop into specialized subsets allow for a robust and tailored immune response in the advent of an infection or injury. Here, CD4+ T-cells are a crucial component within this system, with subsets such as TH1, TH2, TH17, TFH and TREG cells …
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The role of lactate in CD4+ T cell differentiation and function
… been already studied in the context of CD4+ T cells differentiation, nothing was known about the less abundant D- enantiomeric form until now. By supplementing in vitro cultures of Th1 and Th2 cells with exogenous D- or L-lactate, we describe for the first time D-lactate’s enormous potential to …
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Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis
… tuberculosis (Mtb). Even though CD4 T cells are critical for containing Mtb, the immune system rarely eradicates the bacteria, necessitating the maintaining of an antigen-specific CD4 T cell response throughout the course of infection. How this response is maintained is not currently …
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The Suppressive Mechanisms of TIM3 on T Cell Cytokine Production and The Anti-Tumor Effect of TIM3-Pathway Inhibition
… (TIM3) has been shown to be expressed on Th1 cells and negatively regulates these cell functions. TIM3 has been implicated in the Th1-driven pathogenesis of autoimmune disease and the viral infection. However, molecular mechanisms of TIM3 inhibiting Th1 cells and the efficacy of tumor …
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The Role of the IL-23/Th17/IL-17 Axis in the Pathophysiology of Endometriosis
… and progression. Notably, the IL-23/Th17/IL-17 axis is significantly altered in EM and associated with disease severity. This is notable as in other chronic inflammatory diseases, IL-23 drives pathogenic Th17 responses, producing IL-17 to exacerbate disease. Th17 cells are also highly …
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REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
… CD4 T cell responses, called T helper type 1 (Th1), are necessary to control acute parasite growth. On the other hand, IL-21+ T follicular helper (Tfh) cells are essential for generating high-affinity antibodies for parasite clearance. Whereas the transcription factors Bcl6, Blimp-1, and STAT3 …
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Insights Into the Regulatory Requirements for T Follicular Helper Cell Development
… the course of an immune response, CD4+ T helper cells differentiate into a number of subsets including: T helper 1 (TH1), TH2, TH17, and T follicular helper (TFH) populations. The functional diversity of CD4+ T effector cells results in a coordinated, pathogen-specific immune response. For …
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Characterization of Mycobacterium tuberculosis-specific Th22 cells in HIV-TB co-infection
… to TB. Although it is well established that Th1 cells are crucial in the response against Mycobacterium tuberculosis (Mtb), Th1 cytokines may not be sufficient to control Mtb infection. A major focus of this thesis is the contribution of an understudied Th subset in Mtb immunity, namely Th22 …
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Modelling and Investigation of Drug and Immune Therapies for Cancer
… literature supporting the hypothesis that immune cells affect the tumour cells. For example, Mattes et al, show that the tumour (i.e., B16-OVA melanoma) is eliminated by Th1 cells, but Th2 cells reduce the size of tu- mour (i.e., not eliminate the tumour cells). However, Xie et al show that the …
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Inhibition of IFN-[gamma] promoter function by site-specific methylation
When they become activated, naive helper T cells are able to polarize into either THI cells or TH2 cells. Development of naive CD4+ T cells into TH1 cells is characterized by the expression of IFN-y and the silencing of IL-4, while development into TH2 cells is characterized by expression of IL-4 …
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Protein Kinase D1 in Myeloid Cells Promotes Disease Progression and Severity in S. rectivirgula Induced Hypersensitivity Pneumonitis
… to granuloma formation. Myeloid lineage immune cells play a critical role in the early and late stages of the disease, and this activity is mediated through toll-like receptors (TLRs) expressed by these cells. Protein kinase D1 (PKD1) has previously been identified as a critical signaling …
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… nervous system (CNS), driven by autoreactive T cells that mediate demyelination, axonal loss, and neuroinflammation. Among the pathogenic T helper subsets, Th17 cells are pivotal in MS progression, producing high levels of proinflammatory cytokines such as IL-17. While Interferon-gamma (IFN-γ) …
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Adaptive Immunity in Cardiovascular Disease
… and stroke, both affecting millions worldwide. T-cells and antibodies have been implicated in atherosclerosis. This thesis contains studies on CD4+ helper subsets and studies on antibodies against methylglyoxal-modified apolipoprotein B100 (MGO-ApoB100). In the prospective Malmö Diet and Cancer …
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Aging Dendritic Cell Function and Effects on T Helper Cell Differentiation
… but previously published data suggest dendritic cells (DC) largely escape this phenomenon. DC have three main functions: upregulation of cell surface expression of costimulatory molecules, antigen presentation, and cytokine secretion which lead to activation of T cells. The milieu of secreted …
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Dendritic cell regulation of immunity to Leishmania donovani
Dendritic cells lie at the interface of innate and adaptive immunity, critically contributing to the generation of an antigen-specific immune response. Although the mechanisms by which they initiate protective immunity are well characterised, their precise contribution to the subsequent regulation …
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Parasite interactions with dendritic cells and macrophages: Implications for cutaneous Leishmaniasis caused by Leishmania amazonensis
… Previous studies have established the model of Th1-Th2 paradigm: gamma interferon (IFN-g)-secreting Th1 cells protect the host from developing progressive diseases, while interleukin (IL)-4-producing Th2 cells drive the disease pathogenesis. Focused on L. amazonensis infection in mice, this …
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CD46-mediated signals in the regulation of T-cell cytokine production and intestinal wound healing
… regulated by TCR and CD46 signals in CD4+ T cells in an IL-2-dependent fashion and is shown to be defective in rheumatoid arthritis patients. The molecular pathways linked to the CD46-induced switch of TR! cells are largely undefined and were investigated. Gene array studies highlighted the …
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BCG-specific T cell proliferation and cytotoxic capacity in infants as risk of tuberculosis disease, following newborn BCG vaccination
… immunity in clinical trials, specific Th1 cells, are typically thought to be protective in TB. However, to date, human mycobacteria-specific Th1 responses have not correlated with risk of TB disease. New approaches are urgently required to identify other factors at play in conferring …
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