Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Th1/Th2"”.
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Granzym B und TH1/TH2-Zytokine bei Asthma Bronchiale und Rheumatoider Arthritis
… und Bedeutung der Serinprotease Granzym B, der Th1-Zytokine (IL-2, IFN-g, TNF-a) und Th2-Zytokine (IL-4, IL-5, IL-10) untersucht. Das Probenmaterial bestand aus bronchoalveolärer Lavage (BAL) von Probanden mit Asthma bronchiale 10 Minuten und 42 Stunden nach segmentaler Allergenprovokation (SAP) …
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Einfluss von Interleukin-18 auf das Th1/Th2-Zytokingleichgewicht mononukleärer Nabelschnurblutzellen in vitro
… factor" bezeichnet, welcher die Ausbildung einer Th1-Immunantwort stimuliert. In den letzten Jahren konnte für IL-18 zudem die Induktion Th2-spezifischer Zytokine aufgezeigt werden. Bei Atopikern, welche durch das Überwiegen der Th2- gegenüber der Th1-Immunantwort gekennzeichnet sind, ist …
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Methode zur Charakterisierung des Arginin-Metabolismus einzelner Makrophagen nach Stimulation mit Th1 & Th2 Zytokinen
… einzelner Makrophagen nach Stimulation mit Th1 & Th2 Zytokinen
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The association between psychosocial factors, angiogenesis & host Th1/Th2 immune response in patients with colorectal cancer
… the host immune response against the tumour. The Th1/Th2 cytokine profile plays an important part in determining how the immune system operates and modulation of this has potential therapeutic value.The efficacy of treatment for colorectal cancer is based on four primary end points: tumour …
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Charakterisierung von Monozyten anhand ihrer Interleukin-10-Produktion und Darstellund der Existenz funktionell unterschiedlicher Subpopulationen (M1/M2) analog den Th1/Th2-Schema
… Da Vorarbeiten nahe legten, dass das Th2-Zytokin IL-10 und das Th1-Zytokin IL-12 dichotom in Monozyten exprimiert werden, wurden insbesondere die Antigen-präsentierenden Eigenschaften der unterschiedlichen Monozytengruppen untersucht. <br>Wir konnten zeigen, dass sich insbesondere die …
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Towards unravelling the immunomodulatory mechanisms of S. mansoni & L. major parasites in a mouse model using transgenesis
… iii) Differentiate the OT-II cells into Th1, Th2 and Th17 cells in vitro and demonstrate their functional phenotype, and iv) Investigate whether the parasites expressing OVA are able to influence the cytokine expression profile of the Th1, Th2 and Th17 OT-II memory T cells. To achieve …
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Transcriptional analysis of the role of CD8+ T lymphocytes in acute neural herpes simplex virus infection / David C. Tscharke.
… investigated, with particular reference to the Th1/Th2 paradigm and a known anti-viral mediator, IFN-[gamma]. A non-directed method of mRNA analysis is applied to HSV infected ganglia with the specific aim of identifying transcripts that may be associated with CD8+ T cell activity in the nervous …
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Modulation der Immunglobulinproduktion bei Ratten mit CD28-spezifischen monoklonalen Antikörpern
… vom TZR-Signal nimmt CD28 Einfluss auf die Th1/Th2-Differenzierung der Immunantwort. Die rattenspezifischen mAk JJ316 und JJ319 binden an das CD28-Molekül und haben beide ein gleich starkes co-stimulatorisches Potential. Gabe des mitogenen CD28-spezifischen mAkJJ316 - und nicht des …
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Understanding the importance of vaccine formulation in generating protective immune responses against Leishmania amazonensis challenge
… while ineffective vaccines induced a mixed Th1/Th2 immune response. These data can help to establish parameters for determing vaccine efficacy in L. amazonensis.
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INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… (1) investigating the HIV reservoir, circulating Th1/Th2 cytokines, gut integrity, and microbial translocation in individuals with PHI and chronic HIV infection (CHI) before and after cART initiation; (2) assessing immune parameters, gut barrier dysfunction, and mitochondrial stress in PLWH …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… follicular helper (Tfh) lineage while repressing Th1, Th2 and Th17 differentiation. Bcl6-deficient mice develop a spontaneous and severe Th2-type inflammatory disease including myocarditis and pulmonary vasculitis, suggesting a potential role for Bcl6 in Treg cell function. Bcl6-deficient Treg …
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Einfluss der Osteopontin Defizienz bei Mäusen auf allergische Hautreaktionen vom Spättyp
… In <br>verschiedenen Modellen konnte eine Th1-Zytokinartige Wirkung von OPN nachgewiesen <br>werden. Kürzlich wurde gezeigt, dass OPN während der Sensibilisierungsphase einer <br>Kontaktallergie in der Haut und in den Haut-drainierenden Lymphknoten vermehrt exprimiert wird und …
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Aging Dendritic Cell Function and Effects on T Helper Cell Differentiation
… of activated naïve T helper (Th) cells into Th1, Th2, Th17 or T regulatory (Treg) cells. We show that bone marrow-derived DC (BMDC) differentiated from old male mice stimulated with Toll-like receptor (TLR) agonists, alone or in combination, secrete increased IL-23, a cytokine involved in the …
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Parasite interactions with dendritic cells and macrophages: Implications for cutaneous Leishmaniasis caused by Leishmania amazonensis
… Previous studies have established the model of Th1-Th2 paradigm: gamma interferon (IFN-g)-secreting Th1 cells protect the host from developing progressive diseases, while interleukin (IL)-4-producing Th2 cells drive the disease pathogenesis. Focused on L. amazonensis infection in mice, this …
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Análise transcritômica de linfócitos T humanos tratados com anticorpos anti-CD3
… inflamatórias para eliminação de patógenos (Th1, Th2 e Th17) ou antiinflamatórias (Tregs) para a manutenção da homeostase do organismo. Anticorpos anti-CD3 pode induzir a diferenciação dos linfócitos T nos subgrupos de Tregs e pode ser usado como moléculas terapêuticas para tratar doenças …
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Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
… regulatory functions. These subsets include Th1, Th2, Th17, natural and inducible regulatory T cells (nTreg and iTreg respectively), among others. We focused our investigation on two Th lineages, Th17 and regulatory T cells, with opposing functions in the immune system. These subsets have …
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A study of invariant NKT cell biology in health and disease
… production and skewed effector responses in a Th1, Th2 or Th17 direction. We similarly identified novel compounds that were able to reduce iNKT anergy after initial activation. Finally we showed that these functional differences were modified by CD1d affinity and the nature of the antigen …
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The role of T cell Immunoglobulin Mucin domain in Herpes Simplex Virus-induced Behçet’s Disease mouse model
… cell surface markers for T helper type (Th)1 and Th2 T cells. TIM-1 plays an important role in the regulation of immune responses and the development of autoimmune diseases. TIM-4 is a natural ligand of TIM-1, and interaction of TIM-1 and TIM-4 is involved in the regulation of Th cell responses …
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The effect of nfa1 accination against Naeglearia fowleri infection
… IgG levels. In particular, both levels of IgG2a (Th1) and IgG1 (Th2) were significantly increased in mice vaccinated with viral vectors. The cytokine analysis showed that vaccinated mice elicited stronger IL-4 and IFN-γ production than other control groups, suggesting a Th1/Th2 mixed type immune …
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