Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 309 for “"Th1"”.
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A role for polyunsaturated fatty acids in Th1-mediated disease
The anti-inflammatory effects of polyunsaturated fatty acids (PUFA) have been well documented, however their exact method of action remains elusive. Dendritic cells (DC) are the most potent antigen presenting cell (APC) and we found that n-3 and n-6 PUFA suppressed IL-12p70 and enhanced IL-10 …
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Granzym B und TH1/TH2-Zytokine bei Asthma Bronchiale und Rheumatoider Arthritis
… und Bedeutung der Serinprotease Granzym B, der Th1-Zytokine (IL-2, IFN-g, TNF-a) und Th2-Zytokine (IL-4, IL-5, IL-10) untersucht. Das Probenmaterial bestand aus bronchoalveolärer Lavage (BAL) von Probanden mit Asthma bronchiale 10 Minuten und 42 Stunden nach segmentaler Allergenprovokation (SAP) …
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Modulation of Allergic Disease through the use of Th1-associated Vaccine Adjuvants
… adjuvant that induced potent antigen-specific Th1 immune responses and determine its ability to reduce the development and severity of Th2- mediated allergic disease, using models of peanut hypersensitivity.</p><p>Three studies were performed. The first study compared a variety of vaccine …
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The Role of IkZF Factors in Mediating TH1/TFH Development and Flexibility
… within this system, with subsets such as TH1, TH2, TH17, TFH and TREG cells playing vital roles in propagating cell-mediated immunity. For example, TH1 cells are essential in combating intracellular pathogens such as viruses, while TFH cells communicate with B-cells to optimize antibody …
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Modelos Th1 y Th2 de secreción in vitro de citoquinas en pacientes polínicos
… las células CD4+ hacia el fenotipo de secreción Th1 o el Th2. Así pues, podríamos decir, en términos generales, que las células con fenotipos de secreción Th1 o Th2 son, respectivamente, supresoras e inductoras de la respuesta alérgica. Cada una de estas subpoblaciones puede predominar sobre la …
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Einfluss von Interleukin-18 auf das Th1/Th2-Zytokingleichgewicht mononukleärer Nabelschnurblutzellen in vitro
… factor" bezeichnet, welcher die Ausbildung einer Th1-Immunantwort stimuliert. In den letzten Jahren konnte für IL-18 zudem die Induktion Th2-spezifischer Zytokine aufgezeigt werden. Bei Atopikern, welche durch das Überwiegen der Th2- gegenüber der Th1-Immunantwort gekennzeichnet sind, ist …
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Regulation and Effector Function of TH1 and TH2 Cells in Immunity to Bordetella Pertussis
The evaluation of vaccines for human use requires reliable models of infection, that are predictive of protective efficacy. Traditionally whole cell pertussis vaccines (Pw) have been controlled using the Kendrick test, which measures protection following intracerebral challenge with Bordetella …
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Methode zur Charakterisierung des Arginin-Metabolismus einzelner Makrophagen nach Stimulation mit Th1 & Th2 Zytokinen
… einzelner Makrophagen nach Stimulation mit Th1 & Th2 Zytokinen
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Immune Cell Subsets Direct or Antagonize Tumor Immunity: Promotion of TH1 Responses in Tumor Vaccination
… marker expression, and by downregulating TBH TH1 cytokine production by splenic CD4+ T cells. Since chemotherapeutic treatments have potent cytostatic effects, we posited they enhance T cell dysfunctionality; which leads to limited therapeutic efficacy. Paclitaxel is a potent chemotherapeutic …
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The association between psychosocial factors, angiogenesis & host Th1/Th2 immune response in patients with colorectal cancer
… the host immune response against the tumour. The Th1/Th2 cytokine profile plays an important part in determining how the immune system operates and modulation of this has potential therapeutic value.The efficacy of treatment for colorectal cancer is based on four primary end points: tumour …
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Dendritic cells activated by CpG motifs are potent inducers of a Th1 immune response that protects mice against leishmaniasis
… manifestations of leishmaniasis and developed a Th1 immune response. protection was solid and long-lasting, and was also dependent of the via of administration. Whe the mechanism of protection was studied, it was observed that the availability of the cytokine interleukin-12 at the time of …
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FUNCTIONAL CHARACTERIZATION OF THE INTERACTION BETWEENP. AERUGINOSA AND DENDRITIC CELLS TRIGGERING THE DIFFERENTIATION OF PATHOGENIC TH1/17 CELLS IN CYSTIC FIBROSIS.
… dannoso di neutrofili e macrofagi, i linfociti Th1/17 co-produttori di IFN-γ/IL-17 sembrano avere un ruolo patogenico cardine nella CF. Nonostante ciò, la connessione tra l’infezione di Pa e la generazione dei linfociti co-produttori di IFNγ/IL-17 non è mai stata caratterizzata. A tal fine, …
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Charakterisierung von Monozyten anhand ihrer Interleukin-10-Produktion und Darstellund der Existenz funktionell unterschiedlicher Subpopulationen (M1/M2) analog den Th1/Th2-Schema
… nahe legten, dass das Th2-Zytokin IL-10 und das Th1-Zytokin IL-12 dichotom in Monozyten exprimiert werden, wurden insbesondere die Antigen-präsentierenden Eigenschaften der unterschiedlichen Monozytengruppen untersucht. <br>Wir konnten zeigen, dass sich insbesondere die beiden …
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The regulation of CXCR4 and CCR5 expression on human monocytes by Th1 and Th2 cytokines: Functional implications on cell migration and HIV infection.
The role of Th1 (IL,-2 and IFN-gamma) and Th2 (IL-4 and IL-13) cytokines in the regulation of CXCR4 and CCR5 expression by monocytes, and the functional implications of Th1 and Th2 cytokine induced alterations in chemokine receptor expression on chemotaxis and HIV infection, are poorly understood …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… neonates succumb to infection despite mounting a Th1-like, but apparently defective, inflammatory response. We further explored whether there are age-dependent differences in IFNg signalling given that both ages of mice expressed this critical cytokine. Both neonatal and adult CD46+ mice express …
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Auswirkung der in-vitro Allergenstimulation auf die Zytokinexpression bei allergischen Erkrankungen : Untersuchung der Bildung von TH1- und TH2-Zytokinen und ihrer Beeinflussbarkeit durch den Histamin-Rezeptor-Antagonisten Desloratadin
… Erkrankungen <br>Untersuchung der Bildung von TH1- und TH2-Zytokinen und ihrer Beeinflussbarkeit durch den Histamin-Rezeptor-Antagonisten Desloratadin <br> <br>In der vorliegenden Arbeit wurde die allergische Entzündung am Modell der in-vitro Allergenstimulation untersucht. Periphere …
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REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
… CD4 T cell responses, called T helper type 1 (Th1), are necessary to control acute parasite growth. On the other hand, IL-21+ T follicular helper (Tfh) cells are essential for generating high-affinity antibodies for parasite clearance. Whereas the transcription factors Bcl6, Blimp-1, and STAT3 …
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Die massive Expression von NF-ATc/A ist eine Eigenschaft Antigen-erfahrener Th1- und Th2-Zellen und trägt zur selektiven Induktion des IL-4 Promotors in Th2-Zellen bei
… T-Zelldifferenzierung erlangen Antigen-erfahrene Th1- und Th2-Zellen schließlich die Fähigkeit zur massiven und induzierbaren de novo Synthese der kurzen Isoform NF-ATc/A. Dies wird infolge alternativer Spleiss- und Polyadenylierungsvorgänge durch die Benutzung einer proximalen, gering-affinen …
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Analysis of the recruitment of the class I myosin Myo5p to endocytic sites in Saccharomyces cerevisiae
… interaction between the Myo5p tail homology 1 (TH1) domain and the most C-terminal portion of the myosin, which includes the SH3 domain. Such interaction precludes the SH3-mediated Myo5p association with Verprolin and Myo5p recruitment to the cortical patch. Using different kinds of experiments, …
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Staphylococcus aureus as a source of antigens stimulating bovine dendritic cells and lymphocytes in vitro
… or LSA induced increased mRNA transcription of Th17-related cytokines and cytotoxic effector memory cell formation during antigen recall experiments. Lymphocytes co-cultured with LSA-loaded DC exhibited a higher fold-change in interferon (IFN) γ mRNA compared to ISA-loaded DC, suggesting the …
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