Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Th cells"”.
-
THE CRITICAL ROLE OF CD4+ TH CELLS IN CD8+ CTL RESPONSES AND ANTI-TUMOR IMMUNITY
The goal of this body of research was to elucidate the mechanism by which CD4+ T cells provide help for CD8+ cytotoxic T lymphocyte (CTL) responses in different immunization types. The establishment of diseases, such as chronic infections and cancers, is attributed to severe loss of or dysfunctions …
-
BMEA: Bayesian Modelling For Exon Array Data
The development of Affymetrix Exon Arrays was a signifcant step forward from 3' Microarray technology, however detection of alternate splicing events proved challenging. In this work a novel method, Bayesian Modelling for Exon Arrays (BMEA), is described which shows an improvement in performance …
-
The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells
… innate immune responses play a critical role in the protection against extracellular or intracellular pathogens. The function of these two types of immune responses is coordinated by CD4+ T-helper (Th) cells. Depending on the cytokine environment, Th progenitor (Thp) cells differentiate into …
-
ADAM10: a Novel Regulator of Mast Cell Function and Activation
<p>In this study we show, to our knowledge, the first description of the role ADAM10 plays on mast cells. ADAM10 is abundantly expressed on mast cells both in vitro and in vivo. Its expression is inhibited by IL-10, a suppressive cytokine. siRNA depletion of ADAM10 on bone marrow-derived mast cells …
-
Aging Dendritic Cell Function and Effects on T Helper Cell Differentiation
Immune function decreases with age. Most aspects of the immune system are affected but previously published data suggest dendritic cells (DC) largely escape this phenomenon. DC have three main functions: upregulation of cell surface expression of costimulatory molecules, antigen presentation, and …
-
Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
<p>CD4<sup>+</sup> T helper (Th) lymphocytes are vital for integrating immune responses by orchestrating the function of other immune cell types. Naïve Th cells can differentiate into different effector subsets that are characterized by their cytokine profile and immune regulatory functions. These …
-
Hyporesponsive synovial fluid T cells in rheumatoid Arthritis
Rheumatoid arthritis is a chronic, usually progressive inflammatory disorder of joints in which the immune system plays a central role in pathogenesis. Both chronically inflamed synovial tissue and synovial fluid (SF) are usually rich in infiltrated CD4+ T helper cells (TH cells) and CD8+ cytotoxic …
-
Identification and characterisation of Group 3 Innate Lymphoid Cells in the renal tract
Innate lymphoid cells (ILCs) bear similarities to T-helper (Th) cells, but lack T cell receptors. The three groups mirror the effector functions of Th1, Th2 and Th17 cells and share the same transcription factors and cytokine profiles. This project focussed on type 3 ILCs (ILC3s) found primarily at …
-
Effects of Puberty and Obesity on Central Nervous System Autoimmunity in Experimental Autoimmune Encephalomyelitis
… (MS) is a chronic neuroinflammatory disease that is characterized by the formation of inflammatory demyelinating lesions in the central nervous system (CNS) white matter. One of the largest risk factors for developing MS is being female. The female preponderance of MS only manifests …
-
In Vitro Studies of the Anti-Leukaemic Activity of Bezafibrate and Medroxyprogesterone Acetate Against Chronic Lymphocytic Leukaemia
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the western world, and continues to have very low cure rates. The bulk of the tumour cells are non-cycling peripheral cells that accumulate from a minority of dividing cells within proliferation centres (PCs), located the lymph …
-
Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates
<p>Respiratory syncytial virus (RSV) is one of the leading causes of bronchiolitis in children. We have shown that neonatal mice respond to primary RSV infection with T helper type 2 (Th2) biased immune responses, which are enhanced following reinfection. Dendritic cells (DCs) including myeloid DCs …
-
Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
… repeated inhalation of environmental antigens. The disease is characterized by alveolitis and granuloma formation; however, some patients develop chronic HP (CHP), a restrictive lung disease characterized by fibrosis. Previous studies revealed that neutrophils are recruited into the lung via a …
-
Parasite interactions with dendritic cells and macrophages: Implications for cutaneous Leishmaniasis caused by Leishmania amazonensis
Protozoan Leishmania is an important human pathogen that affects millions people worldwide. Investigation of experimental Leishmania infection in mice has been instrumental to our understanding of interactions between the parasite and the host immune system. Previous studies have established the …
-
Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
As a means to understand the significance of transcriptional regulation of Th cells in MS pathogenesis, we investigated the role of the transcription factors T-bet and PPARalpha in the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a …
-
Regulation of T cell effector functions in the intestinal mucosa
… lymphocytes are a critical cellular component of the adaptive immune response. They are generated in the thymus from bone marrow derived progenitors, where they undergo commitment to the T cell lineage and differentiate and mature into naïve CD4+ and CD8+ T cells. Naïve CD4+ and CD8+ T cells …
-
Systems Genetics and Systems Biology Analysis of Paraquat Effects in BXD Recombinant Inbred Mice
<p>Paraquat (PQ) is a chemical herbicide that is used in many countries including the United States. It is also highly acutely toxic to humans and has been used as a means of suicide. As PQ is applied mainly in agricultural settings, it moves to soil and well water. Chronic low dose exposure via …
-
The effects of ES-62 on DC maturation and effector function
… filarial nematodes are often tolerated in their human hosts for decades, with little evidence of pathology, due to parasite-induced immune modulation. The consensus of opinion, to date, is that such parasites achieve prolonged survival as a result of their active modulation of the host’s …