Global ETD Search
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Showing 1 to 2 of 2 for “"Tg737orpk"”.
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Mutation of Polaris, an Intraflagellar Transport Protein, Shortens Neuronal Cilia
… cilia are shortened in the kidney tubules of Tg737orpk mice, which have polycystic kidney disease due to ciliary defects. The product of the Tg737 gene is polaris, which is directly involved in a microtubule-dependent transport process called intraflagellar transport (IFT). In order to …
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Mutationsanalyse des intraflagellaren Transportprotein-Gens hTg737 bei Patienten mit Situsanomalien und hereditären Nierenerkrankungen
… Mäuse, die homozygot für die Insertionsmutation Tg737orpk sind, weisen renale und hepatische Fehlbildungen sowie Skelettanomalien und einen Hydrocephalus auf. Für die Knock-out-Mutation Tg737Delta2-3ßGal homozygote Mäuse sterben intrauterin und zeigen Situsanomalien, Neuralrohrdefekte, …