Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Tfh cells"”.
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations were made in mouse models. Our knowledge on the biology of human Tfh cells …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations were made in mouse models. Our knowledge on the biology of human Tfh cells …
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Regulation of Autoimmune Germinal Center Reaction By Tfh Cells and Application of Tfr-Like Cells For The Treatment of Autoimmune B Cell Responses
<p>Excessive follicular helper T (Tfh) cell responses to self-antigens are associated with antibody-mediated autoimmune diseases in humans including systemic lupus erythematosus (SLE). Numeral and functional aberrations of T regulatory T (Treg) cells are common in patients with autoimmune diseases. …
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Regulation of the germinal center reaction by T helper cells and T regulatory cells
… antigen. Within the GC, follicular T helper (TFH) cells promote GC B cell differentiation and in turn the proper antibody production to protect us from invading pathogens. We wished to study the regulation of this process by transcription factors STAT3 and Bcl6. STAT3 is important for both TFH …
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Age-associated Changes in the Germinal Centre Response Upon Vaccination
… vaccination through the production of memory B cells and long-lived antibody-secreting plasma cells. However, the GC response deteriorates with age contributing to poor humoral immunity after vaccination and therefore to increased susceptibility to infections in older individuals. I aimed to …
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STEPWISE DIFFERENTIATION OF IL21-PRODUCING FOLLICULAR HELPER T CELLS REVEALS DISTINCT DEVELOPMENTAL AND FUNCTIONAL STATES
The interaction of follicular helper T (Tfh) cells with B cells within the germinal center of secondary lymphoid organs is essential for the formation of high affinity antibodies, a key effector mechanism of adaptive immunity. Interleukin (IL)-21 is a proinflammatory cytokine produced by Tfh cells, …
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Correlation Matrix Analysis Identifies Gene Signatures of Immune Cell Subsets and Their Interactions In Follicular Lymphoma
… benign immune cell subsets and neoplastic B cells within follicular lymphoma (FL). Using the novel technique of correlation matrix analysis (CMA) of publicly available FL whole-tumor gene expression profiling (GEP) data, we have identified signatures of immune cell subsets. Overall survival …
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Analysis of Adenosine 2a Receptors During the Immune Recognition of Foreign and Self-Antigens
… CD4 T cell differentiation by diverting helper T cells away from a germinal center follicular helper T cells (GC-Tfh) linage that promotes the survival, differentiation, isotype class-switching, and affinity maturation of B cells. Although GC-Tfh cells are beneficial during the clearance of …
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REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
… On the other hand, IL-21+ T follicular helper (Tfh) cells are essential for generating high-affinity antibodies for parasite clearance. Whereas the transcription factors Bcl6, Blimp-1, and STAT3 regulate the development of Tfh cells, T-bet and STAT4 direct the commitment of Th1 cells. Since our …
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Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
… the differentiation of germinal center (GC) B cells and follicular T helper (TFH) cells. The interaction of TFH and GC B cells is necessary for the development of high affinity antibodies specific for an invading pathogen. Germline BCL6-deficient mouse models limit our ability to study BCL6 …
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Expression of Follicular Helper T-cell Markers in Primary Cutaneous T-cell Lymphoma
… and objectives: A distinct subset of T helper cells, named follicular helper T- (TFH) cells, have been recently described. The TFH-cells can be identified on the basis of the expression of several markers including: the chemokine CXCL13; the costimulatory molecules PD-1 and inducible …
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Germinal centre autoantibody responses following heart transplantation
… graft-versus-host allorecognition of recipient B cells by donor CD4 T cells transferred within the heart allograft. Rejected allografts displayed features of chronic humoral vascular rejection, with rejection mediated by long-lasting germinal centre (GC) responses, whose maintenance was dependent …
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Transcription factor regulation of T helper subset function
… protects the body from foreign organisms. T cells and B cells are integral components of the ability of the immune system to generate focused immune responses. The development of specialized subsets of T helper cells is governed by transcription factors. Previous work demonstrated a …
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Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice
… humoral immunity and failure to expand CXCR5⁺ TFH cells.
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The Role of IkZF Factors in Mediating TH1/TFH Development and Flexibility
The ability of cells within the adaptive immune system to develop into specialized subsets allow for a robust and tailored immune response in the advent of an infection or injury. Here, CD4+ T-cells are a crucial component within this system, with subsets such as TH1, TH2, TH17, TFH and TREG cells …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
CD4 T helper cells control immunity to pathogens and the development of inflammatory disease by acquiring the ability to secrete effector cytokines. Cytokine responsiveness is a critical component of the ability of cells to respond to the extracellular milieu by activating Signal Transducer and …
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Characterization of Allergen-Specific Immunoglubulin E Development in a Food Allergy Model and Its Regulation by T Follicular Helper and T Follicular Regulatory Cells
… of IgE is regulated by T follicular helper cells (TFH) and T follicular regulatorycells (TFR) in the germinal center (GC). We aimed to understandthe regulation of IgEin the GC by TFH and TFR cellsusinga mouse food allergy model. We found that the dosage and timingof allergen delivery into …
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T Helper Cell Dysfunction in ANCA Associated Vasculitis
… that leads to organ dysfunction. Auto-reactive B cells produce pathogenic antibodies against the neutrophil enzymes, myeloperoxidase (MPO) and proteinase 3 (PR3). Genome-wide association studies that identified the relationship between MHC class II genes and ANCA specificity strongly support the …
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TFR Cells Suppress Gut Commensal-Specific IgA Via IL-10
… Through this pathway, T follicular helper (TFH) cells drive affinity maturation by selecting B cells that produce high-affinity Abs, including IgA. Concurrently, T follicular regulatory (TFR) cells, derived from regulatory T cells (Tregs), also regulate this process. TFR cells suppress or …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… deletion of ADAM10 from all peripheral B cells or in post-switch cells leads to severe impairments in humoral responses. When ADAM10 was deleted from all peripheral B cells a decrease in antigen specific IgG production was seen both with respect to serum levels and IgG ASCs, indicating …
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