Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Tfh"”.
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The Role of IkZF Factors in Mediating TH1/TFH Development and Flexibility
… system, with subsets such as TH1, TH2, TH17, TFH and TREG cells playing vital roles in propagating cell-mediated immunity. For example, TH1 cells are essential in combating intracellular pathogens such as viruses, while TFH cells communicate with B-cells to optimize antibody responses against …
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Dysregulated TFH cell and germinal center activation in mice with severe Orientia tsutsugamushi infection
Scrub typhus is a severely understudied tropical disease caused by Orientia tsutsugamushi. It is endemic in, but not limited to, the Asia-Pacific region, with about one million cases reported every year. Its high case fatality rates and impact during WWII and the Vietnam War justify vaccine …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations were made in mouse models. Our knowledge on the biology of human Tfh cells …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations were made in mouse models. Our knowledge on the biology of human Tfh cells …
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Regulation of the germinal center reaction by T helper cells and T regulatory cells
… antigen. Within the GC, follicular T helper (TFH) cells promote GC B cell differentiation and in turn the proper antibody production to protect us from invading pathogens. We wished to study the regulation of this process by transcription factors STAT3 and Bcl6. STAT3 is important for both TFH …
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Insights Into the Regulatory Requirements for T Follicular Helper Cell Development
… 1 (TH1), TH2, TH17, and T follicular helper (TFH) populations. The functional diversity of CD4+ T effector cells results in a coordinated, pathogen-specific immune response. For example, the production of IFNγ by TH1 cells is vital for the clearance of intracellular pathogens, while TFH cell …
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Age-associated Changes in the Germinal Centre Response Upon Vaccination
… and an accumulation of T follicular helper (Tfh) cells compared to adult (2-month old) mice. This indicated a reduction in the magnitude of the GC response with age. The quality of the GC was also impaired as aged mice had lower serum titres of high-affinity antigen-specific antibodies. …
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STEPWISE DIFFERENTIATION OF IL21-PRODUCING FOLLICULAR HELPER T CELLS REVEALS DISTINCT DEVELOPMENTAL AND FUNCTIONAL STATES
The interaction of follicular helper T (Tfh) cells with B cells within the germinal center of secondary lymphoid organs is essential for the formation of high affinity antibodies, a key effector mechanism of adaptive immunity. Interleukin (IL)-21 is a proinflammatory cytokine produced by Tfh cells, …
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A T- és B-limfocita alpopulációk eloszlásának vizsgálata endometriózisos betegekben
… meghatároztuk a follikuláris helper T-limfocita (Tfh) alcsoportok, a follikuláris regulatorikus T-limfociták (Tfr), valamint a különböző érett és naiv B-limfocita populációk arányát. Az endometriózisos pácienseknél a Th2-szerű Tfh sejtek aránya szignifikánsan csökkent (p=0,0415), a Th1/17-szerű …
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Regulation of Autoimmune Germinal Center Reaction By Tfh Cells and Application of Tfr-Like Cells For The Treatment of Autoimmune B Cell Responses
<p>Excessive follicular helper T (Tfh) cell responses to self-antigens are associated with antibody-mediated autoimmune diseases in humans including systemic lupus erythematosus (SLE). Numeral and functional aberrations of T regulatory T (Treg) cells are common in patients with autoimmune diseases. …
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REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
… On the other hand, IL-21+ T follicular helper (Tfh) cells are essential for generating high-affinity antibodies for parasite clearance. Whereas the transcription factors Bcl6, Blimp-1, and STAT3 regulate the development of Tfh cells, T-bet and STAT4 direct the commitment of Th1 cells. Since our …
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Characterization of Allergen-Specific Immunoglubulin E Development in a Food Allergy Model and Its Regulation by T Follicular Helper and T Follicular Regulatory Cells
… IgE is regulated by T follicular helper cells (TFH) and T follicular regulatorycells (TFR) in the germinal center (GC). We aimed to understandthe regulation of IgEin the GC by TFH and TFR cellsusinga mouse food allergy model. We found that the dosage and timingof allergen delivery into thegut is …
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Analysis of Adenosine 2a Receptors During the Immune Recognition of Foreign and Self-Antigens
… a germinal center follicular helper T cells (GC-Tfh) linage that promotes the survival, differentiation, isotype class-switching, and affinity maturation of B cells. Although GC-Tfh cells are beneficial during the clearance of certain pathogens, they also can be detrimental if they malfunction …
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Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
… center (GC) B cells and follicular T helper (TFH) cells. The interaction of TFH and GC B cells is necessary for the development of high affinity antibodies specific for an invading pathogen. Germline BCL6-deficient mouse models limit our ability to study BCL6 function in T cells due to the …
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Expression of Follicular Helper T-cell Markers in Primary Cutaneous T-cell Lymphoma
… of T helper cells, named follicular helper T- (TFH) cells, have been recently described. The TFH-cells can be identified on the basis of the expression of several markers including: the chemokine CXCL13; the costimulatory molecules PD-1 and inducible costimulator (ICOS); and the transcription …
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Pten Signaling in Regulatory T Cells and Inflammatory Disease
… in excessive TH1 and T follicular helper cells (TFH) responses, associated with elevated germinal center (GC) B cells and spontaneous development of autoimmune and lymphoproliferative disease in vivo. Interestingly, the exaggerated TFH and GC responses and autoimmune symptoms are suppressed when …
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Germinal centre autoantibody responses following heart transplantation
… cognate help from recipient T follicular helper (TFH) cells, and which diversified to encompass responses against vimentin autoantigen. Heart grafts transplanted into stable donor/ recipient mixed haematopoietic chimeras also provoked GC autoimmunity and were rejected with similar tempo, …
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Correlation Matrix Analysis Identifies Gene Signatures of Immune Cell Subsets and Their Interactions In Follicular Lymphoma
… signatures, including T follicular helper (TFH) cells. Comparison of gene signatures between FL and tonsils (n=24) suggested that TFH cells and macrophages are qualitatively distinct in FL from normal tissue. “Cross-correlation”, between FL NB fraction signatures and individual B fraction …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
… including IL-6, Twist1 represses Th17 and Tfh differentiation by directly binding to, and suppressing expression of, the Il6ra locus, subsequently reducing STAT3 activation. In contrast, Etv5 contributes only modestly to Th1 development but promotes Th differentiation by directly activating …
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Influence of Outdoor Air Quality on Maxillofacial Growth and Development
… of facial depth (FD), total face height (TFH), lower face height (LFH), facial axis (FA), and mandibular plane (MP) were made on the initial T1 lateral cephalometric radiographs. Statistical Analysis: Spearman's rho was used to determine if an association existed between the pollution …
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