Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Tfeb"”.
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Inhibition of TFEB activation promotes Coxiella burnetii growth
… regulated by the master transcription factor EB (TFEB). Its ability to act as a transcription factor depends on its subcellular localization, which relies on its phosphorylation state. TFEB, when phosphorylated is cytosolic and inactive, whereas dephosphorylated TFEB translocates to the nucleus …
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MODULATION OF TRPML1/TFEB PATHWAY FOR THE TREATMENT OF WILSON DISEASE
… exocytosis via transcription factor EB (TFEB), stimulating copper clearance and reducing toxicity. Lysosomal Ca2+ release through transient receptor potential mucolipin 1 (TRPML1) activates calcineurin, which dephosphorylates TFEB, promoting its nuclear translocation. In this study, we …
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MODULATING TFEB ACTIVITY IN THE BIRT-HOGG-DUBE' SYNDROME BY TARGETING THE VACUOLAR ATPASE
The transcription factor EB (TFEB) is a master regulator of lysosome biogenesis and autophagy, and its activity is primarily controlled by the kinase complex mTORC1. In the Birt-Hogg-Dubé (BHD) syndrome, a genetic disease caused by germline mutations in FLCN gene, TFEB was found to be …
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The Transcription Factor TFEB Protects Against Cardiac Hypertrophy by Increasing Lysosomal Capacity and Activating AMPKα
… unknown. Recently, the transcription factor EB (TFEB) has emerged as a key regulator of lysosomal genes in multiple tissues, especially in response to external stress. Here, we set out to test the hypothesis that TFEB-dependent control of lysosomal biogenesis is required in the setting of …
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TRPML1: Role In Autophagy And Potential Target To Treat Lysosomal Storage Disorders
… the phosphatase calcineurin and of its substrate TFEB, a master transcriptional regulator of lysosomal biogenesis and autophagy. Lysosomal Ca2+ release via mucolipin 1 (TRPML1) activates calcineurin, which binds and de-phosphorylates TFEB, thus promoting its nuclear translocation. Induction of …
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Investigation of mTOR-independent regulation of macroautophagy
… key autophagy regulators ATG13, ULK1, ATG14 and TFEB. Consequently, mTORC1 has become a candidate therapeutic target in neurodegeneration and cancer; however, its essential role in other cellular programs has prompted the investigation of mTORC1-independent regulation of autophagy. This thesis …
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FoxO1 in the regulation of adipocyte autophagy and biology
… autophagy through the transcription factor EB (Tfeb), which was previously shown to regulate both autophagosome and lysosome. Chromatin immunoprecipitation assay demonstrated that FoxO1 directly bound to the promoter of Tfeb, and inhibition of FoxO1 attenuated the binding, which resulted in …
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MIT/TFE FACTORS CONTROL ER-PHAGY VIA TRANSCRIPTIONAL REGULATION OF FAM134B
… the nutrient responsive transcription factors TFEB and TFE3—master regulators of lysosomal biogenesis and autophagy—control ER-phagy by inducing the expression of the ER-phagy receptor FAM134B. The TFEB/TFE3-FAM134B axis is activated in chondrocytes by FGF signalling, a critical regulator of …
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Estudio de la regulación de la dinámica de localización subcelular de HLH-30: evidencia de un mecanismo dependiente de redox
Los factores de transcripción TFEB y TFE3 son los principales reguladores de la inducción de la autofagia y la biogénesis lisosomal en mamíferos. En condiciones de crecimiento basal, la fosforilación de un residuo de serina clave, S211 en TFEB y S321 en TFE3, por la quinasa mTORC1, permite la …
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The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
… autophagy flux and transcriptional factor EB (TFEB), a master stimulator of lysosomal biogenesis. Increased hepatic TFEB function promoted bile acid synthesis and prevented hepatic cholesterol and triglyceride accumulation in response to Western diet challenges. Pharmacologically targeting …
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The Dynamics and Function of the Endolysosomal/Lysosomal System
… lysosomal stress. Firstly, an assay measuring TFEB-GFP translocation to the nucleus gave a robust and quantifiable readout of lysosomal perturbation. Secondly, a qPCR assay was developed to measure lysosomal gene upregulation as a downstream reporter of TFEB-activating lysosomal perturbations, …
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Fluorescence lifetime imaging microscopy to study protein aggregation in the context of neurodegenerative diseases
… as modulated by transcription factor EB (TFEB). The latter is triggered by increased de-acidification of lysosomes, which also leads to a collapse in tubular endoplasmic reticulum (ER) and mitochondrial fission. Macroautophagy needed for degradation and clearance of aberrant FUS aggregates …
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Mechanism and Functions of STING-Induced Noncanonical Autophagy
… the activation of MiT/TFE transcription factors (TFEB, TFE3, and MITF), promoting endolysosomal biogenesis. Furthermore, we showed that STING-induced noncanonical autophagy induces ALIX-meditated ESCRT machinery recruitment to mitigate endolysosomal perturbation. Our study unraveled the …
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Regulation of mTORC1 by homocysteine and its effects on autophagy in human and mouse neuronal tissues
… reduces LC3 lipidation. mTORC1 also dampens TFEB-driven transcription of autophagy-related genes resulting in a buildup of abnormal proteins, including [beta]-amyloid and phospho-Tau. Formation of these protein aggregates leads to AD-like neurodegeneration. This pathology can be prevented by …
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The interconnected KIT receptor and Microphthalmia-associated transcription factor axis in melanoma
… restricted heterodimerization of MITF towards TFEB, TFEC and TFE3, the binding of M-box DNA sequence and the ability to produce interallelic complementation. In short, the detailing of KIT and MITF regulation has increased our understanding of key signaling processes that are important to …
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INHIBITING THE NUCLEAR RECEPTOR ESRRA RESCUES CORE PATHOLOGIES IN CELLULAR AND ANIMAL MODELS OF BATTEN DISEASE
… gene of lysosomal biogenesis and autophagy TFEB. To validate these findings in a living organism, we treated CLN7 knockout mice with XCT-790 via dietary supplementation of the compound. The treatment successfully reduced Gb3 and SCMAS accumulation in the brain's cortex and cerebellum, and …
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