Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Tfam"”.
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INTERPLAY BETWEEN MDM2 AND TFAM REGULATES OXIDATIVE PHOSPHORYLATION IN DRUG-RESISTANT ONCOGENE-ADDICTED CANCERS
… cancers through an interaction with TFAM. This phenomenon involves the mitochondrial-cytoplasm shuttling of MDM2 in a p53-independent manner, which leads to enhanced mitochondrial biogenesis via TFAM transcriptional machinery. Furthermore, we describe an increase in AKT signalling in …
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Involvement of mitochondrial transcription factor A (TFAM) in porcine gametogenesis and preimplantation embryo development
Mitochondrial Transcription Factor A (TFAM) is responsible for maintenance and transcriptional control of mitochondrial DNA (mtDNA). TFAM knockout is embryolethal. We have studied the expression and distribution of TFAM in the gametes and preimplantation embryos of a domestic pig (Sus scrofa), a …
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LINKING CHROMATIN REMODELING TO MITOCHONDRIAL DYSFUNCTION: A ROLE FOR THE SMARCA5-MYC-TFAM AXIS IN HEPATOCELLULAR CARCINOMA
… In this context, MYC aberrantly interacts with TFAM, a key regulator of mitochondrial DNA transcription, thereby blocking its import into mitochondria. Supporting this model, our findings showed a reduction of mitochondrial TFAM protein levels together with an increased MYC–TFAM interactions in …
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Effect of Denervation on the Regulation of Mitochondrial Transcription Factor a Expression in Skeletal Muscle
… In this study, we analyzed the expression of Tfam, a critical mitochondrial transcription factor involved in the orchestration of mitochondrial biogenesis, at multiple levels during denervation. Tfam transcriptional activation was depressed during the early stages of denervation but was …
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The Effect of Leucine Supplementation on Biomarkers of Mitochondrial Biogenesis and Protein Synthesis in Soleus Muscle of Rats Fed a High-Fat Diet
… of mitochondrial protein synthesis markers TFAM, mtIF2, and TUFM, and mitochondrial biogenesis regulatory factors PGC-1α and COX-IV. METHODS: Male, Sprague-Dawley rats (n = 30 / dietary treatment) were fed either a control diet (C), control + leucine (CL), high-fat (HF), or high-fat + …
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
… of mitochondrial transcription factor A (Tfam), which regulates mitochondrial transcription and replication. Hyperoxia also induced activation of NRF-1 and NRF-2 in EC-SOD KO mice after 6 hours but down-regulated Tfam and PGC1α transcripts. But after 72 hours, mRNA expression for NRF-2, …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
… with mitochondrial transcription factors A (TFAM). Nevertheless, we observed that mitochondria dysfunction was increased via alteration of ROS level, integrity of membrane potential, mitochondria cristae structure and ATP content. To explore signaling pathways regulating the phenotypes, we …
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MITOCHONDRIAL DNA COPY NUMBER AND AUTOPHAGY IN THE AGING BRAIN AND IN AN ALZHEIMER MOUSE MODEL
… these questions, mitochondrial DNA (mtDNA), TFAM (transcription factor A mitochondrial) and two stages in autophagy, autophagosomal formation and degradation were measured in the hippocampus/cortex of non-transgenic (non-Tg) and the APP(Swe, DI)/NOS2-/- AD mouse model (AD-Tg) from 2 mo. …
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Investigating neuronal mitochondrial DNA loss in Drosophila melanogaster
… and overexpression of the mtDNA binding protein TFAM causes reduced mtDNA content and lethality. TFAM RNAi or overexpression specifically in motor neurons causes locomotion defects during development and age-related behavioural defects in adult flies. This demonstrates that maintenance of mtDNA …
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The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
… to peripheral neuropathy. These mice: Tfam-SCKOs) were produced through the tissue-specific deletion of the mitochondrial transcription factor A gene: Tfam), which is required for mtDNA transcription and replication. Interestingly, induction of SC-specific mitochondrial dysfunction did …
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Acute and chronic heat stress alters the metabolic profile of skeletal muscle in growing swine
… CytB, EEF2, HK2, MURF, ND1, PGC-1α, SDHA, and TFAM during the acute heat stress study. Differences (p<0.05) were observed in protein abundance of 4eBP1, total Akt, and p-Rs6 and gene expression of CytB, MURF, and PGC-1α during the chronic heat stress study. These data indicate that acute …
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Impacts of microRNAs on Skeletal Muscle Protein Synthesis and Mitochondrial Quality
… in mitochondrial content was separate from TFAM or PGC-1α protein as neither was changed by miR-1 or -133 overexpression. Together, these results indicate a clear advancement in the knowledge of the effects miRs -1 and -133 have on protein synthesis and on the mitochondrial network by taking …
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The effect of 10 days of heat acclimation on submaximal exercise economy and efficiency at 1600 m and 4350 m
… also significantly increased PGC-1α, NRF1 and TFAM leading to increased mitochondrial content. These data demonstrate that while heat stress reduces UCP3 expression, thereby reducing uncoupling and leading to enhanced mitochondrial efficiency, these adaptations are not observed in the whole …
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In vitro investigation of the molecular relationship between mitochondrial dysfunction and neurogenesis in autism aetiology
… (mitogenesis) (C-MYC, PGC-α, NRF1, NFE2L2, TFAM) and mitochondrial fusion (STOML2, OPA1) genes were performed to identify PPA-responsive genes and to get initial insights on the effect of PPA treatments on transcriptional regulation of mitostasis. Mitochondrial membrane potential (DYm) was …
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Mitochondrial metabolism and CNS myelination
… myelin sheaths are, 10) in a PI3K-Akt-FoxO3a-Tfam pathway dependent way. These results provide answers to fundamental questions of oligodendrocyte biology and may have important implications for the development of future treatments. Moreover, this is the first study that demonstrates a …
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Carnosic acid against insulin resistance and obesity. Investigating its effects on adipocytes.
… browning protein markers (UCP-1, PGC-1α, PRDM16, TFAM) and mitochondrial biogenesis in an AMPK-dependent manner in 3T3- L1 white adipocytes. Conclusion: These studies demonstrate that CA has a pronounced potential in 1) attenuating the palmitate-induced insulin resistance in adipocytes and 2) …
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Il sistema dell'Eme Ossigenasi-1 (HO-1) nel Glioblastoma Multiforme
… nella biogenesi mitocondriale (PGC1, SIRT1, TFAM), nella fosforilazione ossidativa (ND4, Cytb, COX II, COX IV, Ndufa6, ATP sintetasi) e dinamica (OPA1, MNF2 , MNF1, FIS1). Inoltre, la traslocazione nucleare di Nrf2 è stata valutata mediante analisi immunocitochimica. Nel loro insieme, i …
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Efeitos de dieta hiperlipídica pós-desmame sobre a bioenergética mitocondrial e metabolismo oxidativo de fígado de ratos submetidos à dieta hipoproteica perinatal
… e LP-HL (95,87%, p <0,001). Por outro lado, Tfam mostrou uma diminuição entre LP-HL e LP-NL (22,55%, p <0,001), como também entre LP-HL e LP-NL (18,63%, p <0,01). A expressão gênica de MFN2, CypD e GRP75 não mostrou diferenças entre os grupos. Na análise da expressão de VDAC, houve aumento …
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Molecular bases, pathogenic mechanisms and possible therapeutic approach in Leber's Hereditary Optic Neuropathy
… signaling pathway, such as PGC-1 alpha/beta and Tfam. Future studies will be necessary to identify the biochemical effects of rare pathogenic mutations and to validate the novel candidate mutations here described, in terms of cellular bioenergetic characterization of these variants. Moreover, we …
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Mitochondrial mechanisms in autism spectrum disorder: characterizing the neurotoxic effects of propionic acid in vitro
… metabolism (PGC1α, c-MYC), biogenesis (TFAM, NRF1), fission (DRP1) and fusion (STOML2, MFN1/2, OPA1). Confocal microscopy demonstrated associated disruptions to mitochondrial network morphology and integrity, characterised by decreased mitochondrial volume, increased mitochondrial …
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