Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Tetrodotoxin"”.
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Evolutionary Patterns of Avian Tetrodotoxin Resistance
Beyond Arms Races: Evolution of Tetrodotoxin-Binding Sites in Avian Naᵥ Channels Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels (Naᵥ), inhibiting nerve and muscle function. Some species possess TTX as an anti-predator defense, and some predator species have …
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Chemoenzymatic Formal Total Syntheses of Tetrodotoxin and an Approach to Daphenylline
… chemoenzymatic formal total syntheses of tetrodotoxin and a concise synthetic approach to daphenylline. Advanced intermediates for the syntheses of tetrodotoxin reported by the groups of Fukuyama, Alonso, and Sato were prepared. Key steps included toluene dioxygenase-mediated …
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Establishing a protocol to measure tetrodotoxin (TTX) levels in small bodied newts (genus Lissotriton) in western Europe
Tetrodotoxin (TTX) is a defence toxin most commonly found in marine organisms, and amphibians are the only land vertebrates (tetrapods) which are known to produce TTX. However, the origin of TTX in amphibians remains largely unknown, and our knowledge about the existence and distribution of TTX …
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Tetrodotoxin, fungal pathogen infection, and bacterial microbiome associations are variable in the skin microecosystems of two Taricha Newt species
… against disease, parasitism, and predation. Tetrodotoxin (TTX) is a potent low molecular weight neurotoxin found in genus Taricha, and despite a previously observed negative relationship between differential levels of TTX concentration and Bd infection presence within a given locale, the …
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Adaptive evolution, sex-linkage, and gene conversion in the voltage-gated sodium channels of toxic newts and their snake predators
… exist. These include the convergent evolution of tetrodotoxin resistance in snakes, which has a simple genetic basis and can be used as a model system to investigate the genetic basis of adaptive evolution. Tetrodotoxin is a potent neurotoxin used as a chemical defense by various animals, …
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Sodium channel diversity in the vestibular ganglion : evidence for Nav̳1.5-like and Nav̳1.8-like currents
… which are classified pharmacologically into tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-insensitive (TTX-1) categories. The pattern of Nav channel expression shapes response properties of neurons, while changes in these expression patterns are related to many pathological conditions. …
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The production and synthetic utility of the dioxygenase-derived metabolites of substituted aromatics
… were employed in a synthetic approach toward tetrodotoxin. Enzymatic dihydroxylation of benzoic acid with R. eutropha B9 provided the corresponding ipso-diol that was used in the first total synthesis of pleiogenone A, a bioactive natural product. Experimental and spectral data are provided …
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Novel applications of flow cytometry to assess whole murine skeletal muscle and myonuclei number responses to atrophy and recovery.
… recovery from atrophy produced in response to tetrodotoxin administration to silence a motor nerve and therefore muscular contraction in the ankle dorsiflexor muscles of the rat hindlimb.
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Functional and Categorical Analysis of Waveshapes Recorded on Microelectrode Arrays
… I pharmacologically targeted ion channels with tetrodotoxin (TTX), tetraethylammonium (TEA), 4-aminopyridine (4-AP), and monensin.
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Heterogenous Change in Neuronal Bursts Following Recovery from Activity Silencing
… activity patterns after 48hrs of exposure to tetrodotoxin, as indicated by paradoxical spike and correlation statistics. It was found that the cultures recovering from activity silencing did not resemble a neuronal system with enhanced excitation, but differed significantly from control …
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Regulation of Neuronal Excitability by Glutamate and Cholecystokinin Rodent Neocortex
… in apparent input resistance and persisted in tetrodotoxin. This depolarization was mediated by CCKB subtype receptors, and resulted from a reduced linear K+ current as well as an increase in a nonselective cation current. I also found that CCK produces excitatory responses in layer V pyramidal …
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Possible role of the ventromedial hypothalamus in estrus termination following vaginocervical stimulation of the rat
… a microinfusion of a Na + channel blocker, tetrodotoxin (TTX), into the VMH an hour before receiving 50 manual VCSs, with a lubricated glass rod distributed over the course of 1h, while the second group received a microinfusion of TTX and sham VCSs. The remaining groups received a …
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A Pharmacological Analysis of the Ionic Channels of Nerve
… associated with their changes were calculated. Tetrodotoxin abolished the sodium currents selectively, and tetraethylammonium ion abolished the potassium currents selectively. Neither of these drugs affected the time constants associated with any of the current components. The curves relating …
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Evaluation of Zinc Toxicity Using Neuronal Networks on Microelectrode Arrays: Response Quantification and Entry Pathway Analysis
… by stopping spontaneous activity with either tetrodotoxin (200 nM) or lidocaine (250 mM). However, recovery was not complete and slow deterioration of network activity continued over 6 hrs. Removal of zinc by early medium changes showed irreversible, catastrophic network failure to develop in …
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Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
… Glutamate application in the presence of tetrodotoxin (TTX) inhibited neurite outgrowth. Interestingly, TTX inhibited neurite growth, suggesting the neurons may be spontaneously active. Glutamate-induced neurite retraction may be due, in part, to increases in intracellular calcium levels, …
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3,4-Diaminopyridin evozierte Freisetzung von Neurotransmittern aus Hirnschnitten von Ratten
… sich die 3,4-DAP evozierte Freisetzung als Tetrodotoxin-sensitiv und abhängig von der extrazellulären Kalziumkonzentration. Es wurde damit gezeigt, dass 3,4-DAP eine "quasi-physiologische" Transmitterfreisetzung auslöst. <br>2. Bei den Untersuchungen an alten Ratten fanden sich zwar …
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