Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Tetrazines"”.
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Tetrazines and N-Rich Organic Compounds Throughout the Fields of Materials Chemistry
… rich research avenues one may explore through tetrazines and other N-rich organic molecules, in the pursuit of rationally designing novel materials.
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Diels -Alder reactions of [60]fullerene with 1,2,4,5-tetrazines and additions to [60]fullerene-tetrazine monoadducts
… reaction between [60]fullerene and 1,2,4,5-tetrazines was studied. Under conditions of total darkness, [60]fullerene reacts with tetrazines to form bicyclic intermediates which immediately extrudes nitrogen to yield C2nu symmetric monoadducts. Thus, 3,6-diphenyl and 3,6-di-(2 …
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Synthetic strategies for control of structure from individual macromolecules to nanoscale materials to networks
… demand Diels-Alder reactions of norbornenes and tetrazines were used to signal changes in micelle size and stability through the addition of either hydrophilic or hydrophobic tetrazines.
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New applications of Imidazotetrazinone prodrugs. Synthesis and mechanistic investigation of novel imidazotetrazinones as prodrugs of aziridines and as traceless carriers for drug delivery to the central nervous system.
… in neutral aqueous solution of some these new tetrazines were similar to temozolomide, in addition to useful acid stability. Other imidazotetrazinones were synthesised for the purpose of releasing alcohols and phenols. Their synthesis was performed with a one-carbon linker between the …
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The Development of Novel Tools for the Metabolic Labelling of Glycans in Cancer
… Diels-Alder reaction (IED-DA) with tetrazines. The methylcyclopropene tagged monosaccharide most often used in vitro (Ac4ManCyoc) has yet to be used for in vivo applications. This is believed to be due to its lack of aqueous solubility. Herein a method is described for variable …
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Developing unstrained alkenes and alkynes for bioorthogonal chemistry
… pre-targeting manner. Enol ethers can react with tetrazines to decage protected amino acids and prodrugs. Potassium arylethynyltrifluoroborate, as a novel dienophile, was shown to react fast with pyridyl tetrazines controllably and this new IEDDA was applied to label proteins site-selectively and …
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Tetrazine-Triggered Bioorthogonal Decaging Reactions for Prodrug Activation
… Diels-Alder (IEDDA) reaction between tetrazines and strained alkenes exhibits high reaction rates and selectivity and has been widely applied for the decaging of amine prodrugs. Although amines are common in small molecule drugs, decaging methods for other functional groups are …
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Rational design of polymer networks and bottlebrush block copolymers
… materials. Chapter 2: A dual role for 1,2,4,5-tetrazines in polymer networks: combining Diels-Alder reactions and metal coordination to generate functional supramolecular gels In this chapter we report the synthesis, characterization, and application of a new type of supramolecular metallogels …
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Leveraging Bioorthogonal Chemistry for Hyperpolarized Magnetic Resonance and Metal Uncaging
… probes. Bioorthogonal handles such as azides and tetrazines are shown to be a viable, highly generalized approach to overcome these lifetime limitations in a variety of molecular probes. Additionally, in the field of inorganic chemistry, we hypothesize the potential use of bioorthogonal “click” …
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Preparation and Evaluation of Molecular Imaging Probes Targeting the Urokinase Plasminogen Activator System
… and bioorthogonal chemisty based on radiolabeled tetrazines and transcyclooctene (TCO) functionalized biomolecules. A new tetrazine synthon was developed that can be readily labeled with both 99mTc and 18F where the products were produced in 75 and 31 % radiochemical yields. Stability studies …
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Wirelessly addressable chemiresistors : carbon nanotube-based chemical sensors and dosimeters
… Specifically, di-substituted- 1,2,4,5-tetrazines are employed as a model inverse-electron demand Diels-Alder agent for the dosimetric detection of ethylene. Possible device architectures and fabrication strategies are explored, including colorimetric and chemiresistive implementations. …