Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Tetratricopeptide repeats"”.
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Understanding tetratricopeptide repeats of <i>O</i>-GlcNAc transferase
… factor-1 (HCF-1). OGT contains an N-terminal tetratricopeptide repeat (TPR) domain, with some evidence to suggest that this domain plays a role in substrate and adaptor protein binding. However, our understanding of the mechanisms underlying OGT substrate recognition and specificity remains …
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The Interplay of RSV and IFITs: A comprehensive analysis of human and bovine Interferon-Induced Proteins with Tetratricopeptide Repeats induction and interaction with human and bovine Respiratory Syncytial Virus
The interferon-induced proteins with tetratricopeptide repeats (IFITs) are early-response antiviral proteins conserved across vertebrates. Following stimulation of cells, they are amongst the most highly induced genes, although the patterns of induction kinetics of individual IFIT proteins are …
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A study on human IFIT3 modulation of IFIT1 protein stability
Interferon-induced proteins with tetratricopeptide repeats (IFITs) are expressed in both interferon-dependent and interferon-independent manners in cells after pathogen-associated molecular pattern recognition by the pathogen recognition receptors. Four IFITs (IFIT1, IFIT2, IFIT3 and IFIT5) have …
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Biochemical and Structural Studies of the Role of FKBP(L)s in the fly and Mammalian Circadian Cycle
… domain that interacts with DOUBLETIME and tetratricopeptide repeats at its C-terminal region that may mediate protein-protein interaction. We used similar techniques to identify BDBT vertebrate functional homologues FKBP51, FKBP52 and FKBPL. In vitro kinase assays showed that all three …
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Mutationsanalyse des intraflagellaren Transportprotein-Gens hTg737 bei Patienten mit Situsanomalien und hereditären Nierenerkrankungen
… eine Größe von 833 AS und weist 10 Kopien eines Tetratricopeptide Repeats (TPR) auf. Es existieren zwei Mausmodelle mit Defekten in Tg737. Mäuse, die homozygot für die Insertionsmutation Tg737orpk sind, weisen renale und hepatische Fehlbildungen sowie Skelettanomalien und einen Hydrocephalus auf. …
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Demonstration of Interactions Among Dif Proteins and the Identification of Kapb as a Regulator of Exopolysaccharide in Myxococcus Xanthus
… pathway in M. xanthus. In addition, KapB, a TPR (Tetratricopeptide repeats) protein, was identified as an interacting partner of DifE byY2H library screening. Further analysis demonstrated that the N-terminal half of KapB interacted with the putative P2 domain of DifE. KapB had been previously …
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Construction and Biological Characterisation of Custom Engineered Protein Degradation Tools.
… of different AurA- and E3-binding sequences: tetratricopeptide repeats (TPRs), RAD protein, and monobodies. The structures, stabilities and binding of the grafted scaffolds were investigated. Characterisation included circular dichroism spectroscopy to ensure correct folding and thermal and …
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Structural Basis Of Epigenetic Regulation And Protein Scaffolding In Development And Diseases
… structural similarity between the CTD and the tetratricopeptide repeats (TPR) suggests a possible mechanism for the Hsp90-mediated SMYD activity enhancement. Based on such knowledge, we then employed the co-crystallization approach to study the mechanisms for the substrate recognition. We have …
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Strengths and Weaknesses of Hybrid TPR Technology for Obtaining Structural and Mechanistic Insights into TPR Proteins
<p>Tetratricopeptide (TPR) repeats are a 34-residue helix-turn-helix motif that when repeated pack into a superhelical structure. TPR domains are frequently found mediating protein-protein interactions, often through a central groove. One protein complex bearing numerous TPR repeats is the Anaphase …