Global ETD Search
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Showing 1 to 19 of 19 for “"Tetraspanins"”.
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Regulation of C-type lectin-like receptors dectin-1 and CLEC-2 by tetraspanins
Tetraspanins are a superfamily of glycoproteins that function as ‘organisers’ of membranes by clustering with each other to form tetraspanin-enriched microdomains, into which certain other receptors and signalling proteins are recruited and regulated. Tetraspanin microdomains have been implicated …
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Investigations of tetraspanin functions using large extracellular loops
… domain: the large extracellular loop (LEL). Tetraspanins are involved in cellular migration, adhesion, and metastasis, sperm-egg fusion, and viral infectivity. The large extracellular loop domain is the major extracellular domain of tetraspanins and the binding of a monoclonal antibody …
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Characterization of the Tetraspanin protein Tspan18
Tetraspanins are a superfamily of four-transmembrane proteins. They associate laterally with one another and with other transmembrane proteins to form membrane microdomains, in which associated proteins are regulated. Tetraspanins regulate diverse processes such as cell signalling and fusion, …
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Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man
… two diseases have consumed research interests. Tetraspanins are cell surface proteins that organize the cell membrane. Cellular membrane organization is a prerequisite for cellular signaling to occur. Deregulation of cellular signaling often precedes the formation of cancer or vascular disease …
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Comprehensive Proteomic Analysis and Characterization of Human Bone Marrow Mesenchymal Stem/Stromal Derived Extracellular Vesicles
… analysis identified EVs expressing exosomal tetraspanins (CD63/81/9) and western blot analysis confirmed an enriched expression of MMP-2 and HSP90B1 in hBM-MSC-EVs. Quantitative proteomic analysis performed using Tandem Mass Tag labeling combined to LC-MS/MS identified 5108 proteins in …
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TUMOR-PROMOTING FUNCTION AND MOLECULAR REGULATION OF TSPAN8 IN LIVER CANCER
… cell surface presentation of TSPAN8 and other tetraspanins. Collectively, our findings unmasked the potential of TSPAN8 as a diagnostic biomarker and therapeutic target in liver cancer and provided novel insights into its molecular regulation.
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THE ROLE OF TETRASPANIN-8 IN ASTROCYTE ELEVATED GENE-1 MEDIATED PROGRESSION OF HEPATOCELLULAR CARCINOMA
… of AEG-1. TSPAN8 belongs to the family of TETRASPANINS with the characteristic of crossing the membrane four times, and regulating a wide range of cellular phenomena. TSPAN8 is implicated in metastasis and is classified as a metastasis promoting tetraspanin. To understand the role of TSPAN8 …
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Molecular assessment of parasite infection within socioeconomically important UK salmonid populations
… D. baeri, utilizes intracellular antigens Tetraspanins and Venom allergen-like antigenic proteins. These antigens were isolated using genomic techniques to highlight potential vaccine targets in aquaculture. The body of work presented here has furthered the knowledge of the highly infective …
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The Tetraspanin CD9 Localizes to Platelet-Platelet Contacts and Regulates Thrombus Stability
… platelets (50,000-80,000 copies per platelet). Tetraspanins have been implicated in modulation of integrin function, and it is hypothesized that CD9 will modulate GPIIb-IIIa, the major platelet integrin.</p> <p> The association between CD9 and GPIIb-IIIa was analyzed using immunoprecipitations …
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Development of exosome-based anti-cancer therapeutics
… of fluorescence, exosome marker detection, tetraspanins expression, particle count, metabolic and lipidomic profiling, RNA sequencing, and gene expression. This difference indicates that the effect of media composition is inevitable on cell-derived exosome which may cause misinterpretation …
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DISSECTING THE ROLE OF THE TETRASPANIN MS4A4A IN MODULATING MACROPHAGE PLASTICITY AND FUNCTION
… cell types and structural similarities to tetraspanins, including the ability to interact with and modulate the activity of various immunoreceptors, such as pattern recognition receptors (PRRs) and Ig receptors. MS4A4A is selectively expressed by macrophages, and its expression is …
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The Role of the YXXΦ Motif in CD82 Trafficking and Function
… a tetraspanin, is a tumor metastasis suppressor. Tetraspanins are membrane spanning proteins that play critical roles in diverse biological and pathological processes, e.g., the regulation of cancer metastasis. CD82 is ubiquitously expressed in various types of tissues, but its expression becomes …
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THE ROLE OF EXTRACELLULAR VESICLES IN HEART DISEASES
… for surface markers (e.g. CD9, CD63 for tetraspanins; CD14 for monocytes; CD206 for macrophages; CD202b for endothelial cells; CD172a for cardiomyocytes; CD66b for neutrophils; CD41a for total platelets). For targeted (Olink) and untargeted (HPLC-MS/MS) proteomic profiling, EVs were …
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Impact of chemotherapy on the release and function of extracellular vesicles in the pre-pubertal testis
… markers, but not all EVs were positive for these tetraspanins. Bulk assessment of EVs for TSG-101 identified both GC1 and TM4 EVs expressed this marker. Mouse Type-B spermatogonia (GC1) and Sertoli (TM4) cells treated with cisplatin release approximately twice as many EVs as control cells, (GC1, …
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Expression of Tetraspanin Markers in Benign Prostate Hyperplasia and Prostate Cancer // Експресия на тетраспанинови маркери при доброкачествена хиперплазия и карцином на простатната жлеза
През последните години бяха постигнати значителни успехи в по-прецизното стратифициране на пациентите с простатен карцином с цел избягване на ненужни терапевтични интервенции или недостатъчно агресивно лечение при привидно нискорискови тумори. Независимо от постигнатите резултати в изясняването на …
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Ceramide-Induced Alternative Translocation of TM4SF20
The polytopic membrane protein TM4SF20 (transmembrane 4 L6 family 20) is a protein containing four transmembrane helices that inhibits the Regulated Intramembrane Proteolysis (RIP) of the transcriptional factor CREB3L1 (cAMP response element binding protein 3-like 1), a transcription factor …
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Tetraspanin KAI1/CD82 inhibits cell migration-related cellular events via reorganizing actin network
<p>To determine how tetraspanin KAI1/CD82, a tumor metastasis suppressor, inhibits cell migration, we assessed which motility-related cellular events are altered by KAI1/CD82 and how KAI1/CD82 regulates these events. We found that KAI1/CD82-overexpressing cancer cells exhibit various morphologies …
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Molecular Mechanism of Tetraspanin CD9 Mediated Cell Motility
<p>CD9, a member of the tetraspanin superfamily of proteins participates in the regulation of cell adhesive functions such as cell migration. The mechanisms underlying CD9 mediated cell migration are not known. In the current study, we investigated the molecular basis for the CD9 promoted cell …