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Showing 1 to 8 of 8 for “"Tetramic Acid"”.
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Synthesis and Spectroscopic Study of Anticancer agent A-007 Prodrugs and Progress Towards the Synthesis of Tetramic acid Antibiotics
… prodrugs are presented in this dissertation. Tetramic acid (2, 4 pyrrolidine-2, 4-dione ring system) containing compounds have been found to display a remarkable diversity of biological activities and have attracted the interest of medicinal and synthetic chemists. Magnesidin …
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The Design and Synthesis of β-Keto Vinyl Sultams and Macrocyclic β-Keto Vinyl Sultams: Novel Analogs of Tetramic Acids
… Similarly, natural products possessing the tetramic acid core structural motif have emerged as a rich chemotype due to their potent and broad biological activities. Several bioactive tetramic acid-containing compounds have been reported with a variety of activities, including antibacterial, …
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Synthesis and Evaluation of Tetramic Acids as Antimicrobial Agents
… exhibiting antimicrobial activity possess a tetramic acid (2,4-pyrrolidinedione) functional group. As their antibacterial mechanism of action is different from that of many of the currently available antibiotics, these compounds have potential to serve as a basis for a pharmacophore in …
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Syntheses of natural bioactive 3-acyltetramic acids and derivatives
… the side chain). Therefore, a L tyrosine derived tetramic acid was coupled to different side chains, which were synthesised separately, by applying varying 3 acylation conditions. Macroetherification via palladium catalysis and subsequent deprotection provided the desired macrocycles. The second …
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Total synthesis of naturally occurring glycosylated tetramic acids
… first synthesis of a naturally occurring 3-acyl tetramic acid glycoconjugate was investigated. An endofungal metabolite called epicoccamide D was synthesized for the first time. This was accomplished in 19 steps resulting in a 17% overall yield. The total synthesis was built on a modular base to …
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Development And Applications Of Thioacids In Peptide Chemistry And Exploration Of Methods Toward The Stereochemical Elucidation And Synthesis Of Virgineone
… <p>DEVELOPMENT AND APPLICATIONS OF THIOACIDS IN PEPTIDE CHEMISTRY AND EXPLORATION OF METHODS TOWARD THE STEREOCHEMICAL ELUCIDATION AND SYNTHESIS OF VIRGINEONE</p> <p>by</p> <p>KASINATH SANA</p> <p>December 2010</p> <p>Advisor: David Crich</p> <p>Major: Chemistry</p> <p>Degree: Doctor of …
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Towards the Synthesis of Magnesidin
… chelate of the 3-hexanoyl and 3-octanoyl tetramic acid derivatives isolated from <em>Psuedomonas magensiorubra</em>. Its activity against grampositive bacteria was found to be a specific target for Gingivitis, a dental plaque.Although the synthesis of magnesidin has been reported earlier, …
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The Design and Synthesis of Novel Antimicrobial Agents for Use in the Battle Against Bacterial Resistance
<p>There is an ever increasing need to develop new antimicrobial agents with novel mechanisms of action. These new agents will help to combat the steady rise of antibiotic-resistant bacteria which are becoming more and more difficult to treat due to the dwindling number of antibiotics available to …