Global ETD Search
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Showing 1 to 10 of 10 for “"Tetrahydropyridines"”.
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Oxidation of Tetrahydropyridines by MAO B Biomimetics: Mechanistic Studies
… model for the oxidation of -unsaturated tetrahydropyridines. Using a nontoxic analog of MPTP, 1-methyl-4-(1-methyl-1-H-pyrrol-2-yl)-1,2,3,6-tetra-hydropyridine (MMTP), reactions with 3MLF were performed under both aerobic and anaerobic conditions. The anaerobic studies of these reactions …
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[4 + 2] cycloadditions of iminoacetonitriles : synthesis of highly substituted tetrahydropyridines and indolizidine alkaloids
… aza Diels-Alder reactions affording tetrahydropyridines and indolizidines. The [alpha]-amino nitrile cycloadducts are versatile synthetic intermediates that participate in a variety of stereoselective transformations to further elaborate the six-membered ring. This thesis describes …
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Synthesis and mechanistic studies on the monoamine oxidase (MAO) catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridines
The parkinsonian inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is bioactivated in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium (MPDP+) subsequently pyridinium (MPP+) metabolites. As part of our ongoing studies to …
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The Investigation of the Active Sites of Monoamine Oxidase (MAO) A and B and the Study of MAO-A Mediated Neurotoxicity Using 4-Substituted Tetrahydropyridines
… sites, we have synthesized series of substituted tetrahydropyridines, evaluated their biological activity with purified MAO-A and MAO-B, and carried out a topological analysis of the MAO active sites using molecular modeling. In addition, the results described in this thesis provide evidence that …
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Studies on the monoamine oxidase substrate/inactivator properties of piperidine analogs of the neurotoxin MPTP
… of 1-cyclopropyl-4-substituted-1 ,2,3,6-tetrahydropyridines have been interpreted in terms of partitioning of these tertiary cyclic allylamines between substrate turnover and ring opening inactivation processes. To evaluate further this proposal, we examined the bioactivities of the …
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New chiral molybdenum metathesis catalysts : application to the enantioselective preparation of cyclic amines
… of unsaturated prochiral amines to afford tetrahydropyridines (2.68a-e). The selectivity of this transformation was sensitive to the olefin substitution pattern of the prochiral amine. However, this novel method was also applicable for the formation seven-(2.84), and eight-membered (2.84) …
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Bicyclic Heterocyclic Systems Derived from 1, 3, 4-Trisubstituted Pyridines
… Several new 1,3,4-trisubstituted-1,2,5,6-tetrahydropyridines are prepared by reduction of the appropriate pyridinium iodides with sodium borohydride. The reduction of 3,4-dimethoxycarbonyl-1-methyl pyridinium iodide by sodium borohydride gives the expected tetrahydro derivative and …
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Mechanistic Studies on the Monoamine Oxidase B Catalyzed Oxidation of 1,4-Disubstituted Tetrahydropyridine Derivatives
… the MAO catalyzed oxidation of 1,4-disubstituted tetrahydropyridines, deuterium isotope effects studies on both the substrate and inactivation properties of the 4-benzyl-1- cyclopropyl derivative were undertaken. A series of 1-methyl- and 1-cyclopropyltetrahydropyridine derivatives bearing various …