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Showing 1 to 1 of 1 for “"Tetrahydrolipstatin"”.
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Phosphate Tether-Mediated, One-Pot Metathesis Processes: Application in Small Molecule Synthesis
… synthesis of the pancreatic lipase inhibitor (-)-tetrahydrolipstatin (THL) is reported. THL is a currently marketed as an anti-obesity drug under the generic name Orlistat®. The concise approach to this molecule invokes cross-metathesis, chemoselective hydrogenation, regio- and diastereoselective …