Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Tetrahydrocannabinol (THC)"”.
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Development of molecularly imprinted polymer (MIP)-based microfluidic gas sensors for Tetrahydrocannabinol (THC) detection
… good candidates for the selective detection of Tetrahydrocannabinol (THC), the primary psychoactive ingredient in Cannabis, as there is an emergent need for new technologies to selectively detect and monitor THC for health, safety, and quality control applications, especially portable …
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The Effects of Δ9-tetrahydrocannabinol (THC) on development and hyperekplexia in embryonic zebrafish model
… produced by the cannabis plant, Δ<sup>9</sup> – tetrahydrocannabinol (THC) has been shown to the most efficacious phytocannabinoid in neurological disorders. THC has been shown in numerous previous studies to be effective at treating spasticity caused by multiple sclerosis and spinal cord injury, …
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A New Method for the Synthesis of the Terpene Precursors for the Terpene Portion of Δ-1-Tetrahydrocannabinol (THC).
Marijuana and hashish have been under focus in recent years by governmental, social, and scientific groups. This attention has triggered the study of chemistry of cannabis sativa, cannabis indica, and other types of plants thought to contain cannabinoid. material. These studies have led to many new …
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CANNABINOIDS DELTA-9-TETRAHYDROCANNABINOL (THC) AND CP55,940 ABLATE SPECIFIC CHEMOKINE AND CYTOKINE INFLAMMATORY RESPONSE IN BV-2 MOUSE MICROGLIAL CELLS ACTIVATED WITH HIV-1 PRO-INFLAMMATORY PROTEIN TAT
… was to determine whether the select cannabinoids THC and CP55,940 could ablate the inflammatory response on BV-2 mouse microglia cells caused by Tat. Within the constraints of the experiment, no major effects of cannabinoid treatment were observed at the level of the proteome as tested by …
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Comparing Extraction Methods in Sample Preparation for the Quantification of Cannabinoids in Industrial Hemp
… Farm Bill) as Cannabis containing <0.3% total tetrahydrocannabinol (THC). The 2018 Farm Bill does not, however, specify standard methods for sample preparation or quantification of cannabinoids (including THC) in Cannabis. Extraction efficiency of phytochemicals is well-known to depend on the …
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Detection and Imaging of Neurotransmitters in Rodent Brain Tissue Using FMP-10 and ZnO Nanoparticle Matrices with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
… female adolescent rats administered edible Δ-9-tetrahydrocannabinol (THC). Our MALDI MSI data revealed significant downregulation of dopamine, GABA, glutamate, and glutamine levels in the prefrontal cortex and nucleus accumbens of THC-treated males and females. To improve the quantitative …
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A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE
… or its primary psychoactive constituent, delta-9-tetrahydrocannabinol (THC), is gaining acceptance. However, there are no currently approved pharmacotherapies to treat cannabinoid withdrawal. The objective of this thesis was to evaluate whether elevating endogenous anandamide levels using mice …
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Effects of oral delta-9-tetrahydrocannibinol (THC) administration on motor activity and anxiety-like behavior in adolescent and adult Sprague-Dawley rats of both sexes
… and its primary psychoactive component delta-9-tetrahydrocannabinol (THC) may induce modifications in neural circuitry that in turn lead to adverse consequences on behavior. Previous literature has suggested that intraperitoneal, intragastric, or subcutaneous administration of THC may produce an …
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The use of tetrahydrocannabinol (marinol) in cancer patients undergoing chemotherapy
… effect of Marinol, which contains the antiemetic tetrahydrocannabinol (THC), was evaluated in five cancer patients undergoing chemotherapy. Subjects rated their nausea and vomiting, food intake, appetite and mood status three times daily. Drug therapy (THC) or no drug was administered for an …
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Characterizing the Developmental and Reproductive Toxicities of Cannabidiol and Δ9-Tetrahydrocannabinol
… without including low concentrations of Δ9-tetrahydrocannabinol (THC). The goal of this project is to characterize the relative morphological, behavioral, reproductive, and multigenerational toxicities following a developmental F0 exposure to 0.024–5 mg/L (0.08–16 µM) THC or 0.006–1.2 mg/L …
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Cannabinoid Modulation Of Cisplatin Induced Neuropathy
… a cannabinoid extract with a 1:1 ratio of tetrahydrocannabinol (thc) and cannabidiol (cbd) has been shown to alleviate neuropathic pain associated with chemotherapy. This research examined whether thc or cbd alone is effective in attenuating or preventing tactile allodynia associated with …
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Targeting the Endocannabinoid System to Reduce Inflammatory Pain
… with fewer psychomimetic side effects than Δ9-tetrahydrocannabinol (THC), the primary active constituent of marijuana. While cannabinoid receptor agonists and FAAH inhibitors reliably produce anti-inflammatory and anti-hyperalgesic effects in the carrageenan test and other inflammatory pain …
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Preformulation Characterization And Formulation Development of Δ9-Tetrahydrocannabinol Prodrugs For Potential Treatment Of Glacuoma
… could be linked to this observation. Delta-9-Tetrahydrocannabinol (THC) was one of the ingredients identified. However, four decades and numerous research efforts since the first observation, it has still not been concluded whether THC is effective in the treatment of glaucoma or not. Current …
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EFFECTS OF CANNABIS CONSTITUENTS ON OVARIAN HEALTH AND FUNCTION: A FOCUS ON PRENATAL EXPOSURE
… gap by evaluating the impact of delta-9-tetrahydrocannabinol (THC), the psychoactive component of cannabis, on ovarian health and function, focusing on the long-term effects of prenatal exposure and the underlying mechanisms. Gestational THC exposure resulted in altered follicle dynamics, …
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Behavioral Mechanisms of Δ9-THC in Nonhuman Primates
… effects and cognitive consequences of Δ9-tetrahydrocannabinol (THC), the primary psychoactive constituent in marijuana, is critical for developing treatments in cannabis dependent patients. Despite the fact that marijuana is the most commonly abused illicit substance in the U.S., …
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Cannabinoids and Psychosis – Cause and Treatment
… illness. The main active ingredient is Δ-9-Tetrahydrocannabinol (THC). In healthy humans, the acute administration of THC can elicit transient psychotic symptoms and cognitive impairment. THC stimulates the endocanabinoid CB1 receptor (CB1R). However, beyond CB1Rs, the mechanism underlying …
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Non-Psychotropic cannabinoids attenuate visceral pain in colitis
… not have the prohibitive psychotropic effects of tetrahydrocannabinol (THC). These non-psychotropic cannabinoids (npCBs) have a variety of effects including analgesia and anti-inflammatory actions and show potentiating effects when administered in combination. This project explored the analgesic …
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Cyclodextrins as a suitable carrier for the induction of feeding and analgesia by Delta-9 THC: a preclinical study in the female rat
… consistent and effective oral delivery of Δ9-tetrahydrocannabinol (THC) remains challenging due to the compound’s low aqueous solubility, extensive first-pass metabolism, and variable pharmacokinetics. This research explores whether complexing THC with hydroxypropyl-β-cyclodextrin (HP-β-CD) …
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Investigating post-mortem redistribution of drugs in a cohort of suspected unnatural deaths in Cape Town South Africa
… (n=13; 21.3%), 11-nor-9-carboxy-Δ⁹- tetrahydrocannabinol (THC-COOH) (n=20; 37.8%), amphetamine (n=30; 49.2%), methaqualone (n=33; 54.1%) and methamphetamine (n=33; 54.1%). Males represented the majority of cases in the cohort and the mean age of individuals testing positive was 33 …
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Impact of Indoor Sources of Emission on Ambient Air Quality
… quality impacts, I modeled the distribution of tetrahydrocannabinol (THC) emitted from cannabis smoking among indoor compartments. The results showed that THC tends to accumulate on indoor upward-facing surfaces, leaving a small fraction of emissions airborne. I examined the involuntary exposure …
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