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Showing 1 to 20 of 193 for “"Tetracycline"”.
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Tetracycline in Tumor
The attraction of the tetracycline antibiotic for any rapidly growing tissue has been repeatedly observed. This phenomenon is shown by a yellow golden fluorescence of the tissue when placed under an ultraviolet light. The cause of this phenomenon is not known, but is thought to be an …
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Tetracycline-7-boronic acid
… objective of this study is the preparation of a tetracycline-boron-10 derivative which is stable under biological conditions. The boron-10 should then provide a concentration of material capable of accepting thermal neutrons, thus producing localized high-energy alpha radiation. The fact that the …
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A Central Regulatory Locus Controls Tetracycline Regulated Functions on a Bacteroides Tetracycline Resistant Conjugal Chromosomal Element
The genes necessary for regulated Plf activity on the Tc$\sp{\rm r}$ element were localized to an 8 kbp region. This region was known to contain the Tc$\sp{\rm r}$ gene, tetQ, which had already been sequenced. Sequencing of an additional 5 kbp downstream of tetQ has revealed two additional genes. …
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Tetracycline resistance and its dissemination in the Bacteroides group
Tetracycline resistance (Tc$\sp{\rm r})$ in the human colonic Bacteroides and in the related genus Prevotella appears to be conferred by a single resistance determinant. This determinant represents a new class of ribosome protection Tc$\sp{\rm r}$ genes which was designated TetQ, because it has a …
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Cisplatin cytotoxicity associated with tetracycline resistance determinants in Escherichia coli
Tetracyclines, a broad-spectrum class of antibiotics, were discovered in the late 1940s, and became widely used because of their important advantages: they are inexpensive, safe, demonstrate good oral absorption, and are active against a broad range of bacterial pathogens. Unfortunately, as with …
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Absorption, Distribution and Excretion of Oxytetracycline and Tetracycline in Female Beagles
The absorption, distribution and excretion of oxytetracycline and tetracycline were studied in female beagles following intra-arterial and oral drug administration. Concentrations of drug in body fluids and selected tissues were determined by high performance liquid chromatography utilizing an …
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Effects of the antibiotic tetracycline on the honey bee gut microbiome
… in response to disturbance from the antibiotic tetracycline. Tetracycline was chosen because it is the most commonly used antibiotic in beekeeping, and may have negative effects on bees through the disruption of their gut microbiomes. The first study presents a new fecal sampling method for …
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Tetracycline-Associated Regulation of the Transfer Genes of the Bacteroides Conjugative Transposon CTnDOT
… both its excision and transfer are stimulated by tetracycline. The regulation of excision has been described previously. I provide here the first characterization of the organization and regulation of the CTnDOT transfer (tra) genes. RT-PCR analysis of the region containing the tra genes showed …
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Characterizing Bone Turnover in Osteoarthritic Bone Marrow Lesions in Human Knees Using Tetracycline Histology
… resonance imaging (MRI) six months prior to TKA. Tetracycline hydrochloride was administered to produce fluorescent double labels signifying newly mineralized bone. BMLs and paired control (BML-free) regions were identified in the tibial plateaus on the in vivo MRI images before polymethyl …
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Characterization of a novel tetracycline resistance gene from the Bacteroides transposons Tn4351 and Tn4400
A tetracycline resistance ($\rm \sp{*}Tc\sp{r}$) gene that was originally found on two Bactetoides transposons, Tn4351 and Tn4400, confers resistance on Escherichia coli, but only when the cells are grown aerobically. I first showed that the product of the $\rm \sp{*}Tc\sp{r}$ gene is a 44 kDa …
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Incorporation of Tetracycline Hydrochloride into Electrospun Fibrinogen: a study of mechanical properties and time release
… any effect that the addition of the antibiotic tetracycline hydrochloride (0%, 2.5%, 5%, 10% by weight) would have on the mechanical properties of electrospun fibrinogen (110 mg/mL, 120 mg/mL, and 130 mg/mL concentrations). Also, the time release of tetracycline from electrospun fibrinogen was …
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Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination.
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Confocal Laser Scanning Microscopy As A Tool For The Investigation Of Tetracycline Fluorescence In Archaeologicalhuman Bone
<p>Fluorochromes such as tetracycline have been used to label bone for histomorphometric analysis, measuring bone formation, growth, maintenance, and pathology. More recently, similar fluorescence has been observed in ancient human bone. Attributed to tetracycline (TC) exposure, this phenomenon …
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Ultraviolet Light and Fluorescence in Medicine: Their Application to the Problem of Microscopic Localization of Tetracycline
… its light. | The recent discovery is that tetracycline appears to have a preferential localization at tumor sites. Tetracycline's fluorescence upon irradiation with ultraviolet light increases the usefulness of this discovery. But tetracycline's fluorescence has taken many American …
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Design of a Tetracycline Operon Inducible System for the Control of Vaccinia Virus Replication: Implications for Vaccine Development
… be regulated through the addition or removal of tetracyclines. Seven VACV genes were tested in an attempt to control viral replication. For each gene a different recombinant was generated in which the essential gene was placed under the control of <em>tet </em>operon elements. Of the seven VACV …
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