Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"TetraDVP"”.
-
Exploration of novel linker scaffolds enabling the simultaneous rebridging of disulfide bonds for the synthesis of antibody-drug conjugates
… species present, a linker reagent known as TetraDVP, which simultaneously rebridges all interchain disulfide bonds in an IgG1 antibody, has been developed and was recently reported by the Spring Group. The work reported in this thesis explores the translation of this ‘all-in-one’ rebridging …
-
Development of a Novel Bioconjugation Platform for the Generation of Homogenous Antibody-Drug Conjugates
… linkers, which contain four DVP motifs (termed ‘TetraDVPs’). The TetraDVP motif can conjugate to eight distinct cysteine residues, allowing simultaneous rebridging of all four interchain disulfides in an IgG1 antibody with a single linker molecule, a strategy which generates antibody conjugates …
-
Single-Payload Bioconjugation to Native Antibodies And A General Method for the Self-Immolative Release of Amide-Containing Molecules
… the third generation of tetra-divinylpyrimidine (TetraDVP) linkers. These linkers allow for the creation of single-payload antibody conjugates by re-bridging all four interchain disulphide bonds in IgG1 antibodies with a single construct. Unlike earlier generations, the TetraDVPs used in this work …
-
FROM ANTIBODY-DRUG CONJUGATES TO MASKED ANTIBODIES: BIOPHYSICAL INSIGHT FOR THE RATIONAL DESIGN OF FUTURE THERAPIES
… have recently been developed, e.g. DVP and tetraDVP linkers, by the Spring Group in the Department of Chemistry. The impact of the conjugation of DVP and tetraDVP-linkers on the stability and dynamics of the antibody trastuzumab was investigated. Results showed that the linkers destabilised …