Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 158 for “"Tethering"”.
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Multirobot Tethering for Localization and Control
Particle filtering has proven to be an effective localization method for wheeled autonomous vehicles. For a given map, a sensor model, and observations, occasions arise where the vehicle could equally likely be in many locations of the map. Because particle filtering algorithms may generate low …
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REEP5-MFN1/2 tethering in ER-mitochondria crosstalk
… family, as a key mediator of ER-mitochondria tethering through a targeted screen and demonstrated its specific interaction with mitochondria-localized MFN1/2 at MERCs. The interaction involves the C-terminal cytoplasmic domains of REEP5 and MFN1/2. Further analysis revealed that REEP5-MFN1/2 …
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Novel Mechanisms in Zebrafish Otolith Nucleation, Tethering, and Dysfunction
… mechanisms of zebrafish otolith nucleation, tethering, and dysfunction. Here I show that 1) otolith nucleation is impaired in three zebrafish mutants with mutations in polyketide synthase, 2) otolin-1b is a putative component of the cuticular plate and involved with otolith growth and …
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Bioorthogonal Tethering of Drug Fragments to Engineered G Protein-Coupled Receptors
… (GCE) and bioorthogonal chemical reactions for tethering drug fragments adjacent to allosteric sites in GPCRs to increase their potency and enable fragment-based drug screening in cellular systems. C-C chemokine receptor 5 (CCR5) was selected as a model receptor for proof-of-concept studies. …
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Auto-tethering as a selection mechanism for recognition of multimeric substrates by the AAA+ unfoldase ClpX
… signals is referred to in this work as auto-tethering. Additionally, I show that the N terminal domain of CIpX, which plays a role in substrate selection, is important in facilitating discrimination between different multimeric forms of MuA by CIpX. CIpX destabilizes the tetrameric …
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Regulation of Gene Transcription by Estrogen Receptors Alpha and Beta: DNA Binding, Tethering, and Coregulatory Protein Recruitment
Combining various cis-elements and coregulatory proteins to regulate gene expression may allow for differential expression of the gene under different cell environments and physiological conditions. These studies will advance our understanding of the complex mechanisms by which ERalpha is able to …
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"DADDY, ROOT ME IN": TETHERING YOUNG SONS IN THE CONTEXT OF MALE, INTER-GENERATIONAL, CHILD-CENTERED, DANCE EDUCATION
This study of the dance experiences of related men and boys pursues overlapping and related research goals. It is an investigation about reflective teaching practice in the process of developing an emergent curriculum for this multi-generational group of men and boys. It is an investigation about …
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Synthetic strategies to improve the cytotoxicity of platinum-based cancer therapeutics
… cisplatin to platinum(IV) allows for the tethering of amines that can be used to target cancer cells. The first chapter is a brief introduction on the scope of platinum compounds that have been made. It also provides general background on the proposed mode of action. The second chapter …
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Copper/zinc Sods of Salmonella Typhimurium: Enzymatic Properties and Correlation to Pathogenesis
… between SodCI and SodCII: dimerization, tethering, and protease resistance. SodCI is a dimer and is not released from the periplasm by osmotic shock. Thus SodCI is ""tethered"" in the periplasm by some non-covalent interaction. In contrast, SodCII is monomeric and is quantitatively …
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Ionic Liquids Tethered to Activated Carbon for Capture of Airborne Toxins
… by testing absorption capacity of neat ILs and tethering ionic liquids to the surface of AC. AC is known to have good adsorption ability for warfare agents. Functionalizing the AC with ILs could enhance the capture ability significantly. ILs have been found to be good absorbents for a variety of …
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In vitro and in vivo growth factor delivery to chondrocytes and bone-marrow-derived stromal cells in cartilage and in self-assembling peptide scaffolds
… included growth factor adsorption, scaffold-tethering, and modification of growth factor structure. (KLDL)3 was modified to deliver IGF-1 and TGF-[beta]1 to chondrocytes and bone marrow- derived stromal cells (BMSCs), respectively, by adsorption and by biotin-streptavidin tethering. This …
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Reconstitution of Munc18-Dependent Mast Cell Degranulation
… unraveled a previously unidentified role in the tethering of SNARE complexes prior to fusion, an action that is dependent on the interaction between Munc18a and N-peptide of syntaxin. Inhibition of fusion and trans-SNARE complex formation by soluble VAMP proteins did not interfere with …
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Experimental methods by optical trapping for investigation of leukocyte cell rolling mechanics
… during rolling has been probed by simulating the tethering phenomenon in vitro. However, previous work has focused on pulling tethers at a constant velocity where as during in vivo rolling the tether extension will be a function of time. The fundamental differences between constant velocity and …
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WDR5 Network Analysis Using Ensemble Approaches
… conditions, we have explored the role of surface-tethering in modulating the kinetics of these PPIs. The work shows the impact of tethering on tethered ligand-receptor complexes that are common in biological signaling and cellular adhesion. Moreover, it shows how surface-tethering can be used to …
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Homeostatic Elastic States and the Stability of Elastic Arteries
… and alterations in blood pressure, vessel tethering forces and geometry and material properties. The mechanical state experienced by blood vessels plays a critical role in mechanical homeostasis and mechanical stability, and there remains a pressing need for mechanical/mathematical analysis …
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The regulation of yeast homotypic vacuole fusion and membrane trafficking events by sphingolipids, ergosterol, and lipid rafts
… activity of SNAREs, small GTPases, chaperones, tethering complexes, and specific regulatory lipids. This process occurs in four experimentally defined steps: priming, tethering, docking, and fusion. Work with baker’s yeast identified interdependence between a set of pro-fusion proteins and …
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Nanoemulsion-like Polymersomes for Nanoreactors
… transfer of polymersomes in terms of a reduced tethering density for poly(ethylene oxide) (PEO), and analyzed the phenomena thermodynamically. The tethering density can be increased by increasing the block length of PEO and the size of the polymersomes, and the increased tethering density …
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Engineered [beta]TCP-binding HER-family protein fusions and their use for improving osteoprogenitor- mediated bone regeneration
… alternative to enhance bone regeneration by tethering EGF onto a graftable, osteoconductive matrix, beta-tricalcium phosphate ([beta]TCP). Due to the lack functional groups for bioconjugation on the [beta]TCP surface, the tethering strategy involved the use of a high-affinity [beta]TCP …
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