Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Tetanus toxin"”.
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Die vollständige Entschlüsselung der Genomsequenz des Tetanus-Erregers <i>Clostridium tetani</i> und die Analyse seines genetischen Potentials
… kann, besser bekannt als Wundstarrkrampf (Tetanus). Die Krankheit ist eine der weltweit am weitesten verbreiteten Krankheiten von Menschen und Wirbeltieren. Das Nervengift stellt die zweitgiftigste der Menschheit bekannten Substanzen dar. Das Tetanus-Toxin blockiert die Freisetzung von …
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Development and characterization of novel transgenic techniques for the study of neuronal circuitry
… a mouse line that, through expression of the tetanus toxin light chain, allows long-term inhibition of neurotransmission in a small subset (<1%) of fluorescently labeled pyramidal cells. This model, which can be used to study how a silenced cell performs in a wildtype environment, greatly …
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Development of novel diagnostics and therapeutics for amyotrophic lateral sclerosis
… and treating ALS, including 1) a gadolinium tetanus toxin C fragment (Gd-TTC) biomarker for axonal retrograde transport, 2) TTC-conjugated biodegradable nanoparticles, and 3) poly(glycerol-co-sebacate) acrylate (PGSA) and 3D scaffolds for human embryonic stem cell (hESC) and neuronal …
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Functional changes in connectivity induced by differential manipulations of activity in Drosophila tonic versus phasic motoneurons
… the activity of the Ib or Is neuron with tetanus toxin light chain resulted in structural changes in muscle innervation. Decreased Ib activity resulted in reduced active zone (AZ) number and decreased postsynaptic subsynaptic reticulum (SSR) volume, with the emergence of filopodial-like …
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Evaluation of the Functional Roles of TRPA1 Homologs, Painless and dTRPA1, in Chemical Nociception in Drosophila
… Additionally, we specifically expressed tetanus toxin, which blocks synaptic transmission, to verify that these drivers were capturing the aversive circuit. However, it is unclear whether <italic>painless</italic> and <italic>dTRPA1</italic> are acting independently or in combination. To …
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DNA-Vakzinierung mit Idiotyp Zytokin Fusionskonstrukten gegen Lymphome im Mausmodell
… oder Flt3 ligand) und/oder einem Adjuvans (Tetanus Toxin Fragment C oder HBsAg) gekoppelt. In vitro wurde die Expression, die Faltung des scFv und die biologische Aktivität bestätigt. Neben der spezifischen Zytokinwirkung stabilisieren die Fusionspartner die scFv-Proteine deutlich. Zunächst …
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Development of an oral DNA anti-cancer vaccine targeting an angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
… plasmid (PcPAMP) was generated by fusing the tetanus toxin epitopes P2 and P30 to the mouse PAMP sequence to counteract self-tolerance, and the empty plasmid was used as a negative control (PcNeg). The plasmids were introduced into Salmonella typhimurium bacteria that were then converted into …
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Measurement and Analysis of Calcium-Dependent Exocytosis in Giant Excised Membrane Patches
… by amperometry. Non-SG fusion is reduced by tetanus toxin light chain treatment, however, it is unaffected by N-ethylmaleimide, implying that SNARE cycling is not required for non-SG fusion in excised patches. Although non-SG fusion is ATP-dependent and blocked by PI-kinase inhibitors, …
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The Medial Entorhinal Cortex's role in temporal and working memory : characterization of a mouse lacking synaptic transmission in Medial Entorhinal Cortex Layer III
… mouse which allows for the expression of tetanus toxin, an enzyme that disrupts synaptic vesicle fusion, specifically in MEC-III neurons. Utilizing this triple transgenic mouse model, which allows for the specific and reversible ablation of synaptic transmission only in medial entorhinal …