Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Terminal Protein"”.
-
Multifunctionalization of Proteins: Strategies for Combining Semi-Synthetic and Bioorthogonal Techniques
Proteins play important roles in biological processes including muscle movement, initiating immune responses, and memory formation. Full understanding of protein function requires determining its structure, assignment of function, and elucidation of interactions with other proteins or metabolites. …
-
Assembly of nuclear dimers of the PI3K regulatory subunits underpins the proliferative activity of Activated Cdc42-associated Kinase, ACK
… to dimerise via interactions between their N-terminal protein domains and the work presented here identifies a novel mode of dimerisation mediated by C-terminal protein domain interactions. The pTyr607 residue of one monomer binds to the nSH2 domain of another via canonical pTyr-SH2 binding. …
-
C-terminus of Hepatitis B virus RNase H Domain is Important for HBV replication
Hepatitis B Virus (HBV) DNA polymerase (P) protein consisting of terminal protein (TP), spacer, reverse transcriptase (RT), and RNase H, plays critical roles in viral assembly and replication. RNase H domain is required for HBV DNA replication, however critical motif or amino acid residues in the …
-
Development and Application of Chemoenzymatic Tools to Investigate Site-Specific Protein ADP-Ribosylation
… sites on synthetic peptides and full-length proteins. Historically, chemical and topological complexities associated with ADP-ribosylation have stymied progress in this area. To overcome this, I have identified enzymes capable of: (i) installing ADP-ribose specific side chain functionalities …
-
MOLECULAR BIOLOGY OF HEPATITIS B VIRUS DNA-CELL INTERACTION
… isolation of a novel liver-specific DNA-binding protein which binds to, and activates EII. The cDNA clone of the protein designated here as E2BP, was isolated from a ?gtll expression library constructed from the hepatoma cell line HuH-6 which was screened with a binding site probe derived from …
-
Distinct Functions of POT1 in Telomere Protection and Length Regulation
<p>Telomeres are DNA-protein structures that protect eukaryotic chromosome ends from illegitimate recombination and degradation. Telomeres become shortened with each cell division unless telomerase, a reverse transcriptase, is activated. In addition to playing a protective role of chromosome ends, …
-
Epigenetic Modification as a Therapeutic Target in BRAFV600E-mutated Metastatic Colorectal Cancer
… the combination of bromodomain and extra-terminal protein (BET) inhibition in vivo with standard MAPK-targeted therapies showed deeper inhibition of the MAPK signaling and improved efficacy. Enhancer blockade disrupted the regulation of core transcription factors (TFs) of CRC, including …
-
Urinary prothrombin fragment 1 : a potential role-player in the protection of South African blacks from calcium oxalate kidney stone disease
… presents a study of the inhibitory role of the protein, urinary prothrombin fragment 1 (UPTFI ), and its biochemical characterisation in both population groups. In a preliminary study, the urine composition and inhibitory activity of urine and urinary macromolecules from healthy white and black …
-
Molecular analysis of thecDNA and gene for a major protein from flexible cuticles of the giant silkmoth Hyalophora cecropia
HCCP12 is a major protein found in flexible cuticles of all three metamorphic stages of the giant silkmoth Hyalophora cecropia. The distribution of HCCP12 provides an opportunity to study the differential regulation of gene expression since there are persistent populations of epidermal cells that …
-
Molecular Mechanisms of C11orf95 translocations in cancer.
… trans-activation domains (TAD) of the fused c-terminal protein partner. Specifically, the ZF’s of C11orf95 direct DNA-binding (as shown with ChIP-seq) of the fused protein partner but does not appear to alter the c-terminal protein’s nuclear interactome (identified using qPLEX-RIME and IP-MS). …
-
Distinct functions of POT1 at telomeres.
Telomeres are nucleoprotein complexes that constitute the ends of eukaryotic chromosomes. Telomeres differentiate the end of the chromosome from sites of DNA damage and control cellular replicative potential. The loss of function of telomeres results in several biological consequences. First, …
-
New methods for synthesis and modification of peptides and proteins
Chemical modification of peptides and proteins is an enabling suite of tools for tailoring the properties of these biomolecules to specific applications. A number of bio-conjugation reactions allows fine-tuning of the biological activity, proteolytic stability, and immunogenicity of peptides and …
-
The plasma protein fetuin: common structural features of the mammalian fetuin family
… expression of the bovine plasma glycoprotein fetuin and its homologues in other species has been examined. From the known partial amino acid sequence of bovine fetuin, degenerate oligonucleotide probes were designed. These probes were end-labelled using 14 polynucleotide kinase and …
-
Construction of bovine adenovirus type 3 E1 and E3, substitution plasmids and the sequencing analysis of DNA pol and pTP /
… by E2 including BAV3 DNA pol and precursor to terminal protein. Comparative analysis of these proteins with their counterparts from human and non human adenoviruses revealed important insights as to the evolutionary lineage of BAV3. In order to insert the kanamycin resistance gene in either E1 …
-
Gene Set Analysis of Post-Lactational Mammary Gland Involution Gene Signatures In Inflammatory and Triple Negative Breast Cancer
… vascular smooth muscle cells (VSMC) by c-Jun N-terminal protein kinase (<em>JNK1</em>). We identified 3 genes – Involucrin (<em>IVL</em>), Cluster of Differentiation 79B (<em>CD79B</em>), and leptin (<em>LEP</em>) – that were significantly enriched in IBC compared to non-IBC in both training and …
-
Purification and characterisation of two cancer cachexia factors
… material revealed an identity to Zn-α-2-glycoprotein, the significance of which is discussed. An additional factor, first detected as a result of its specific reactivity with a monoclonal antibody produced by fusion of splenocytes from MAC 16 tumour-bearing mice with mouse BALB/c myeloma …
-
Expression and Functional Analysis of Hepatitis B Virus DNA Polymerase
… Virus (HBV) DNA polymerase is a multifunctional protein with four domains, terminal protein (TP), spacer, reverse transcriptase (RT), and RNaseH. Since HBV DNA polymerase is very unstable and rapidly degradable, it has been very difficult to study the biochemical aspect of HBV DNA polymerase. In …
Page 1 of 2