Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 55 for “"Tenofovir"”.
-
Pharmacogenomics and pharmacokinetics of dolutegravir and tenofovir in Southern Africans living with HIV
… initiating antiretroviral therapy (ART). Tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) are both prodrugs of tenofovir. However, plasma tenofovir exposure is higher when given as TDF, and TAF yields lower plasma but higher intracellular tenofovir concentrations. …
-
Pharmacogenetics of Tenofovir (Alafenamide or Disoproxil Fumarate Prodrug) Renal Toxicity in HIV positive Black Southern Africans
… infection, renal toxicity is more likely with tenofovir disoproxil fumarate (TDF) than with tenofovir alafenamide (TAF). Limited previous studies suggest potential genetic associations with TDF-associated renal toxicity. We hypothesized that polymorphisms in genes of potential relevance to …
-
Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… fixed-dose combination containing dolutegravir, tenofovir, and lamivudine taken daily constitutes one of the most widely used regimens in Africa. In this thesis, we employ population pharmacokinetic modelling to optimise HIV treatment using data from healthy volunteers or PLWH, some of whom also …
-
Rates of Switching First-Line Antiretroviral Regimen Tenofovir-Emtricitabine-Efavirenz combination in a Primary Care Service in South Africa
Introduction: Tenofovir-Emtricitabine-Efavirenz (TEE) fixed-dose-combination (FDC) has been recommended since 2013 as the first-line antiretroviral therapy (ART) for treating HIV for people living with the virus (PLWH) in South Africa. More evidence has emerged to show long term adverse effects of …
-
Cost effectiveness analysis of two alternative interventions for the integration of Tenofovir into South Africa's public sector First Line Antiretroviral treatment regimen
… burden on the public health sector. By providing tenofovir as an alternative to d4T and AZT in first line ART therapy, the South African government would increase the chance of successful ART therapy for patients and the long-term success of the national ART programme. This cost effectiveness …
-
Cost effectiveness analysis of abacavirlamivudine versus tenofoviremtricitabine combination therapy as part of highly active antiretroviral therapy in treatment naive HIV-infected patients
… inhibitors, namely abacavir/lamivudine or tenofovir/emtricitabine. This study is to compare the cost-effectiveness of these two alternatives in the treatment of HIV treatment-naive patients. Methods: A review of the literature was performed to identify relevant randomized controlled trials …
-
The effects of lipid-based nutrient supplements containing vitamins and minerals on renal excretion of electrolyte and tenofovir concentrations in blood among Zambian HIV/AIDS patients
… Minerals on Renal Excretion of Electrolytes and Tenofovir Concentrations in Blood among Zambian HIV/AIDS Patients by Derick Munkombwe Background: Advanced HIV-infection combined with under-nutrition and anti-retroviral therapy (ART) places patients at high risk of electrolyte abnormalities and/or …
-
Acute kidney injury in tenofovir exposed patients in HIV infected individuals admitted at Groote Schuur hospital, Cape Town and Livingstone hospital, Gqeberha, South Africa
Introduction: Tenofovir disoproxil fumarate (TDF) is vastly used in South Africa (SA) as a first line agent for the treatment of human immunodeficiency virus (HIV). TDF is known to be associated with nephrotoxicity with identified risk factors. This study aimed to describe the demographics, …
-
Likelihood of development renal dysfunction after one year of treatment with tenofovir(TDF) in HIV/AIDS patients at the UTH: An analytical cross-section study
… HIV/AIDS patients who had renal dysfunction. Tenofovir Disoproxil Fumarate (TDF) one of the first line antiretroviral drugs in Zambia, has been associated with renal tubulopathy and nephrotoxicity in many studies. In Zambia, TDF has been in use since 2007. This study was set out to determine …
-
Treatment of HIV associated neurocognitive disorders
… neurotoxic. Efavirenz in particular, but also tenofovir and emtricitabine, have been shown to have direct neurotoxicity in preclinical models. Polymorphisms in genes that encode these enzymes or transporters may therefore affect antiretroviral CSF concentrations. Africans are the most …
-
The Development and Validation of a Direct LC-MS/MS Assay for the Determination of Tenofovir-diphosphate in Dried Blood Spots for the Analysis of Clinical Samples
Tenofovir (TFV) and emtricitabine (FTC) are nucleoside reverse transcriptase inhibitors, often used in preexposure prophylaxis (PrEP) trials: where antiretroviral drugs are administered to high-risk, HIV-negative individuals to prevent HIV infection. Both drugs are safe when taken either daily or …
-
Understanding the mechanism of antiretroviral nucleoside analogs as inhibitors of Epstein-Barr virus lytic DNA replication
… including stavudine (d4T), abacavir (ABC), tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF), effectively inhibit EBV DNA replication.
-
Incidence and Prevalence Of Renal Dysfunction In Antiretroviral Therapy (ART) Naïve Patients Starting A Tenofovir (TDF) Based ART Regimen In Mitchell's Plain Community Health Centre (CHC) ARV Clinic
Background: Tenofovir disoproxil fumarate (TDF) has high antiretrovirus (ARV) activity and available in fixed dose combination (FDC). However, it has been found to cause renal dysfunction. Objectives: To document the prevalence, incidence, pattern of occurence and associated factors of …
-
Effect of obesity on dolutegravir exposure in Black Southern African adults living with HIV
… which is markedly higher when combined with tenofovir alafenamide (TAF), the newer tenofovir prodrug instead of tenofovir disoproxil fumarate (TDF). South Africa has a high prevalence of obesity, especially among women. Understanding dolutegravir exposure in the patients with obesity is …
-
Prevalence and incidence of renal dysfunction in patients initiating Antiretroviral Therapy at a Primary Health Care Centre in Gugulethu, Cape Town : a cohort study
Tenofovir disoproxil fumarate (TDF) is used worldwide for the treatment of HIV-1 infection. Tenofovir has been found to be associated with declines in renal function and chronic kidney disease in HIV-infected patients. There are limited data on how soon after antiretroviral therapy (ART) initiation …
-
Prevalence of Hepatitis B in HIV infected persons: choice of antiretroviral therapy regimen and implications for screening
… receiving optimal antiviral treatment, namely tenofovir and/or lamivudine. The relationship between Hepatitis B carriage and liver function was also determined in co-infected persons as measured by liver function tests. A cross sectional study was conducted from 30th August 2011 to 24th April …
-
Clinical, pharmacokinetic, and genetic determinants of change in serum creatinine among Southern Africans on dolutegravir based antiretroviral therapy
… randomised controlled trial of dolutegravir with tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide fumarate (TAF) plus emtricitabine (ADVANCE, NCT03122262). We assessed clinical, pharmacokinetic, and genetic factors associated with the change in serum creatinine from baseline to week 4 …
-
Acceptability, safety, and patterns of use of oral pre-exposure prophylaxis to prevent HIV in healthy, South African adolescents
… study the safety and acceptability of oral PrEP (tenofovir disoproxil fumarate/Emtricitabine) in two adolescent populations in South Africa. HIV-negative participants between 15-19 years old participated in an open-label oral PrEP study over 52 weeks. Participants took daily PrEP for the first 12 …
-
Strategies for optimising TB-HIV co-treatment in children and adolescents with drug-susceptible tuberculosis on rifampicin-based standard regimens
… investigated a twice-daily dosing regimen of tenofovir alafenamide for children co-treated with rifampicin. Lastly, we evaluated clinical outcomes in children with HIV/TB and non-severe TB who received standard antituberculosis dosing. Our findings show that while WHO revised dosing guidelines …
-
Development of Advanced Delivery Systems for Microbicides
… women. One of the FDA approved microbicides, Tenofovir has shown efficacy in suppression of viral replication and exerted no safety concerns towards renal toxicity but low absorption from gel formulation is a concern. Formulations based on combination of microbicides was found to be more …
Page 1 of 3