Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Tendon Healing"”.
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Understanding factors affecting tendon healing: Characterising the role of obesity on tendon healing and homeostasis and augmenting its effects with growth factors
Background: The burden of tendon disease is rising globally with an increasingly ageing and active population. Tears of rotator cuff tendons are common and result in substantial morbidity and healthcare costs. Recently, obesity has emerged as a key and potentially modifiable risk factor for …
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Multi-modal investigation of tendon healing: tendinopathic injury models to novel rehabilitative strategies
To view the abstract, please see the full text of the document.
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Anti-Inflammatory Effect of Adipose-Derived Mesenchymal Stem Cells for Flexor Tendon Healing
… surgical techniques over the past three decades, tendon repairs remain prone to poor clinical outcomes. While previous attempts to improve flexor tendon healing have focused on the later stages of healing: i.e., proliferation and matrix synthesis), the early inflammatory phase of tendon healing …
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Effects of calcium carbonate particulate releasing surgical anchors on bone and tendon healing
… on the differentiation of tissues along the tendon-bone interface. These findings support the intended use of the Calaxo ® screw as a fixation device for rotator cuff repair procedures.
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Effect of a porous collagen-glycosaminoglycan copolymer on early tendon healing in a novel animal model
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1997.
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Tendon Regeneration: Roles of Growth Factors and Phenotypic Diversity in Tendon Stem Cells
Tendon injuries significantly impact quality of life and are often career ending. Mesenchymal stem cell (MSC) therapy is known to augment intrinsic tendon healing, however, little is known of the stem cells endogenous to tendon, the microenvironmental cues that induce tendon differentiation, and …
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Adipose-Derived Adult Stem Cells as Trophic Mediators of Tendon Regeneration
… is a promising new therapy for equine flexor tendonitis. This heterogeneous population of cells may improve tendon healing via the production of growth and chemotactic factors capable of recruiting endogenous stem cells and increasing extracellular matrix production by tendon fibroblasts …
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In vitro characterization and in vivo assessment of equine tendon-derived progenitor cells
… mesenchymal stem cell (MSC)-based therapies in tendon repair. The focus on tendon-derived progenitor cells (TDPCs) for tendon healing is based on the rationale that stem cells obtained from tendons are more phenotypically-committed or ‘primed’ for tenogenesis than cells from other tissues. The …
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Gene expression in healing tendon
Tendon injury is painful and often debilitating, and is a one of the most prevalent soft tissue injuries encountered in the clinic. While common, the underlying molecular and genetic processes of tendon damage and repair remain poorly understood. The work described herein used genome-wide …
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Novel Preclinical Approaches to the Understanding and Treatment of Achilles Tendinopathy
… and a condition that increases the risk of tendon rupture. Effective therapies remain elusive, as anti-inflammatory drugs and surgical interventions show poor long-term outcomes. Eccentric loading of the Achilles muscle-tendon unit is an effective physical therapy for treatment of …
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Accuracy of Open MRI for Guiding Injection of the Equine Deep Digital Flexor Tendon within the Hoof
Lesions of the distal deep digital flexor tendon (DDFT) are frequently diagnosed using magnetic resonance imaging (MRI) in horses with foot pain. The prognosis for horses with DDFT lesions to return to previous levels of performance is poor. Treatment options are limited; consisting of conservative …
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Preclinical translation of therapeutic interventions for tendon injury
The burden of injury to tendon and the attachment between tendon and bone (i.e., the tendon-bone attachment) on quality of life, disability, health care, and the economy is significant. Unfortunately, current therapeutic interventions have high re-injury rates and do not restore the optimized …
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In vitro comparison of equine tendon- and bone marrow-derived cells expanded with FGF-2 prior to culturing with tendon matrix and IGF-I
… (FGF-2) on monolayer expansion of equine tendon- and bone marrow-derived cells prior to culture with autogenous acellular tendon matrix and insulin-like growth factor-I (IGF-I). Progenitor cells were isolated from six young adult horses, expanded in monolayers with FGF-2, and cultured with …
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Triceps-off trans-fascial sleeve approach, functional outcomes and surgical technique in Distal Humerus fractures
… undescribed approach through the triceps tendon called the Triceps-Off, Transfascial Sleeve (TOFS) approach. Method: We conducted an Ambispective cohort study of 10 patients who underwent open reduction and internal fixation of the distal humerus through the TOFS approach at a tertiary …
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The effects of biophysical and biochemical cues on tendon cells: a study of underlying mechanisms in tendinopathy
… disorders and is associated with the tendon microenvironmental changes, including disordered matrix structures, reduced stiffness and altered biochemical signalling. The effect of these microenvironmental cues on tendon cells and tendinopathy progression is poorly understood. …
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Mesenchymal Stem Cell Mechanobiology and Tendon Regeneration
Tendon function is essential for quality of life, yet the pathogenesis and healing of tendinopathy remains poorly understood compared to other musculoskeletal disorders. The aim of regenerative medicine is to replace traditional tissue and organ transplantation by harnessing the developmental …
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Muscle Loading Treatments for Achilles Tendinopathy
… an increased risk of reinjury. Additionally, the healing mechanism for injured tendons forms scar tissue which is characterized by disrupted extracellular matrix rather than complete injury resolution. These structural changes impact the mechanical properties of tendon, reducing their capacity to …
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Focused Ultrasound Methods for the treatment of Tendon Injuries
Tendon injuries are prevalent, debilitating and difficult to treat. Common interventions such as anti-inflammatory medication, growth factor injections and surgery are associated with short-term efficacy and long rehabilitation periods. Tendons possess an incomplete healing response which is …
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Porcine urinary bladder matrix in an in vitro equine model of tenogenesis
Extracellular matrix (ECM) is responsible for tendon strength and elasticity. Healed tendon ECM lacks structural integrity, leading to reinjury. Porcine urinary bladder matrix (UBM) provides a scaffold and source of bioactive proteins to improve tissue healing, but has received limited attention …
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