Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Tendinopathy"”.
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Muscle Loading Treatments for Achilles Tendinopathy
… (eccentric loading) decreases the symptoms of tendinopathy and restores Achilles tendon functionality. However, the mechanism by which these mechanical stimulations induce healing is poorly understood. There is a clinically relevant motivation to better understand the healing cascade in …
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Exosome- and Microrna-based Therapeutic Approach for Tendinopathy
<p>Tendinopathy, characterized by degeneration and chronic inflammation, is a significant clinical burden. Current treatments focus on symptom management but do not sufficiently address its underlying pathology; however, stem cell-based approaches aimed at repairing diseased tissues may overcome …
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The aetiology of pain in chronic midportion Achilles tendinopathy
Background Achilles tendinopathy (AT) is a common injury in athletes and sedentary individuals, which presents as pain and loss of function in the lower limb. Tendon pathology can exist without pain, but the hallmark of the condition is pain, which is classically of insidious onset, related to …
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Extracellular matrix gene sequence variant analyses and Achilles tendinopathy
The primary aim of this thesis was to identify additional genetic elements predisposing individuals to risk of AT using a candidate gene, case-control genetic association approach, and to propose the biological mechanisms underlying this genetic risk. Candidate genes (COMP, THBS2, COL27A1, TNC, …
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Risk factors for Achilles tendinopathy in runners - an investigation of selected intrinsic, kinematic, kinetic and muscle activity factors that are associated with Achilles tendinopathy
… the multifactorial aetiology of Achilles tendinopathy. Variables such as training and injury history, lower limb alignment, running biomechanics and movement variability were investigated. This study also aims to understand how different sensory inputs, such as shoe or pain may affect …
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Novel Preclinical Approaches to the Understanding and Treatment of Achilles Tendinopathy
Achilles tendinopathy is a debilitating condition affecting the entire spectrum of society and a condition that increases the risk of tendon rupture. Effective therapies remain elusive, as anti-inflammatory drugs and surgical interventions show poor long-term outcomes. Eccentric loading of the …
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Optimising Outcome for Achilles Tendinopathy: An Exploration into Cognitive and Contextual Factors
Achilles tendinopathy is a debilitating condition for both active and sedentary people. Clinically it is characterised by a painful response felt in and around the tendon predominantly during tasks involving plantarflexion load; hopping for example. Whilst exercise appears to be a promising …
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The role of infrared thermal imaging in the assessment of chronic midportion Achilles tendinopathy
… of assessment for chronic midportion Achilles tendinopathy. Some of the features of the condition point towards regional heat change and could be reflected through surface skin temperature (TSK) change.This thesis firstly investigated the methodological aspects of IRC’s and created a robust …
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Genetic and epigenetic variation within extracellular matrix genes as risk factors for human tendinopathy
… were never investigated for their role in human tendinopathy. Based on the aforementioned information, this thesis aimed at investigating novel candidate genes that may be associated with ATP and to replicate previously conducted studies in a newly recruited case-control population. Additionally, …
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A Machine Learning Approach for the Objective Sonographic Assessment of Patellar Tendinopathy in Collegiate Basketball Athletes
Patellar tendinopathy (PT) is a knee injury resulting in pain localized to the patellar tendon. One main factor that causes PT is repetitive overloading of the tendon. Because of this mechanism, PT is commonly seen in "jumping sports" like basketball. This injury can severely impact a player's …
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The prevalence of patellar tendinopathy in elite academy rugby players: a role for measuring ground reaction forces?
… suggest that the prevalence of patellar tendinopathy (PT) in rugby populations is increasing. However, from a review of the published literature patellar tendinopathy is not a<br/>condition commonly reported in rugby athletes. PT can have serious consequences for an athlete, which may …
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The effects of biophysical and biochemical cues on tendon cells: a study of underlying mechanisms in tendinopathy
Background: Tendinopathy is a commonly diagnosed musculoskeletal disorders and is associated with the tendon microenvironmental changes, including disordered matrix structures, reduced stiffness and altered biochemical signalling. The effect of these microenvironmental cues on tendon cells and …
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A pathway-based approach investigating DNA sequence variants to implicate the inflammatory pathway in the predisposition to Achilles tendinopathy
The aims of this dissertation were therefore (i) to follow a pathway-based approach investigating genes encoding proteins involved in the ECM degradation and apoptosis signalling cascade for associations with AT and (ii) to identify a polygenic risk model, comprised of several genetic markers …
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The regulation of the COL5A1 gene via the 3'-UTR and its impact on Achilles tendinopathy andother exercise-related phenotypes
… gene via the 3'-UTR and its impact on Achilles tendinopathy andother exercise-related phenotypes
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To investigate whether VEGF and KDR polymorphisms are associated with chronic Achilles tendinopathy and self-reported measurements of tendon pain
Background: Chronic Achilles tendinopathy (AT) is prevalent in the sporting population, specifically in sporting codes with a large running component, and presents as swelling, impaired lower limb function, and pain of insidious onset. Although the mechanisms are unclear, current theories implicate …
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Methodologies for Quantifying and Characterizing Strain Fields Resulting from Focused Ultrasound Therapies in Mouse Achilles Tendon using Ultrasound Imaging and Digital Image Correlation
Tendinopathy is a common pathology of tendons characterized by pain and a decrease in function resulting from changes in the tissue's structure and/or composition due to injury. Diagnosis of tendinopathy is determined by the qualitative analysis of a trained physician usually with assistance from …
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Influence of age and pathology on Achilles tendon properties under functional tasks
Prevalence of Achilles tendinopathy increases with age, leading to a weaker tendon with predisposition to rupture. Previous studies, investigating Achilles tendon (AT) properties, are restricted to standardized isometric conditions. Knowledge regarding the influence of age and pa-thology on AT …
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