Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Tenascin - C"”.
-
Separation and purification of mucins and tenascin-C in breast milk of patients and the investigation of the role of mucins and tenascin-C in the inhibition of HIV-1
… in our laboratory. Another breast milk protein, tenascin-C (TNC), was recently shown to strongly neutralise HIV-1 in a study performed by another group. Therefore, with this knowledge, this study was employed to firstly compare the antiviral properties of MUC1, MUC4 and TNC. Furthermore, the …
-
Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… CX3CL1, CXCL5, CXCL2 and CXCL1, the receptors Tenascin C, OLR1, IL-18 receptor 1 and growth factors, CSF2, CSF3, IL-6, IL1 and FGF18. Downregulated genes were transcription factors/signaling molecules including ID2. Microarray results were confirmed for selected genes (CSF3, CX3CL1, FGF18, …
-
Whole exome sequencing: a customised approach to exploring the genetic basis of musculoskeletal soft tissue injuries
… extracellular matrix (ECM). Genes encoding the tenascin-C (TNC) glycoprotein (9q33.1) and the α1 chain of type XXVII collagen (COL27A1, 9q32), as well as matrix metallopeptidase 3 (MMP3, 11q22) and the α1 chain of type I collagen (COL1A1, 17q21.33), have previously been associated with the risk …
-
Investigating TLR-4 signalling in response to protein ligands
… for example fragments of fibronectin and tenascin-C. The mechanism by which these proteins interact with TLR-4 and induce signalling is unclear. Proteins from the ECM (fragments FNIII1c, FNIII13-14, FNIII9-E and FNIII9-E-14 from fibronectin and the fibrinogen-like globe (FBG) domain of …
-
Mechanisms of Cell Surface Trafficking and Potential Functions of Extracellular Annexin A2
… activator (tPA), plasminogen, procathepsin B and tenascin C. Targeting the Nterminus of AnxA2 with a competitive hexapeptide that prevents the binding of proteolytic components inhibited the AnxA2-mediated neovascular responses. In summary, our data suggests that AnxA2 is transported to the cell …
-
In vivo responses of neural progenitor cells to extracellular matrix signaling under pathological conditions
… migration-inducing peptide sequence derived from Tenascin-C, a glycoprotein natural occurring in the extracellular matrix of the neuro-genic areas. In this paper, we re-directed cells from their normal path, the rostral migra-tory stream, to migrate into the cortex using the Ten-C-peptide …
-
Tissue engineering the anterior cruciate ligament : a regenerative medicine approach in orthopaedic surgery
… markers Collagen type I, Collagen type III and Tenascin-C. Finally, based on the enhancing effect observed in co-cultures, the thesis explores a method to regenerate ACL using a three-dimensional polyglyconate scaffold seeded with cell-hydrogel suspensions containing ACL fibroblasts and MSCs. …
-
Effect of Interstitial Fluid Flow and Radiotherapy on Glioblastoma Invasiveness and Progression
… in diffusivity in a murine glioma model. Tenascin C was found to correlate significantly with invasion and diffusivity, indicating that it might be a link between radiation, transport, and invasion. Furthermore, interstitial fluid flow was calculated and assessed in clinical images. This …
-
Elucidating the chlamydial growth characteristics, infection factors, and host responses to persistent chlamydial infection in women
… composition, however, the gene which encodes tenascin-C was over-expressed in women who had a self-reported history of miscarriage. Comparisons of clinical isolates from women treated for chlamydial infections showed no significant differences in developmental or stress phenotypes but …
-
Corneal fibrosis therapies and investigations in the canine corna in vitro
… p<0.0001), Fibronectin (FN; p = 0.0002), Tenascin C (TNC; p<0.0001), Collagen I (Col-I; p<0.0001), Collagen IIIA1 (Co-IIIA1; p<0.0001), and Collagen IV (Co-lV; p<0.0001). Conclusion: An ophthalmic formulation consisting of lisinopril and fasudil may offer a safe and effective method to …
-
A patient specific total disc replacement to treat degenerative disc disease
… positive cells and Collagen II increasing, and Tenascin-C and Collagen Type I decreasing. This highlights the challenges of quantifying matrix deposition in multilayered cell surfaces using immunofluorescent imaging. These observations emphasise the need for refined analytical methods and …
-
Efficacy of Wearable Therapies on the Ability to Improve Performance and Physical Health in Sport Horses
… (CRP), basic fibroblast growth factor (bFGF) and tenascin-C (TN-C), and capturing thermal images of the distal limb using an HT-19 thermal imaging camera (HTI, La Vergne, TN). In this study, eight healthy horses were exercised for approximately ten minutes per day for five consecutive days. There …
-
An investigation into the anatomical and proteomic properties of the anterolateral ligament (all)
… collagen, decorin, biglycan, fibronectin, and tenascin-C-proteins characteristic of load-bearing ligaments. The FCL showed higher collagen abundance, and the ALL demonstrated high levels of decorin (20-22). In conclusion, this study provides new anatomical, imaging, and biochemical insights …
-
Whole exome sequencing: a customised approach to exploring the genetic basis of musculoskeletal soft tissue injuries
… to specific genes. The genes encoding the tenascin-C glycoprotein (TNC, chromosome 9), the α1 chain of type XXVII collagen (COL27A1, chromosome 9), matrix metalloproteinase 3 (MMP3, chromosome 11) and the α1 chain of type I collagen (COL1A1, chromosome 17) were previously associated with …