Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Temporal Lobe Epilepsy"”.
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Memory Performance in Children with Temporal Lobe Epilepsy: Neocortical vs. Dual Pathologies
This study investigated memory in children with temporal lobe epilepsy and the ability to discern hippocampal dysfunction with conventional memory tests that are typically used to detect more global memory impairment. All data was obtained retrospectively from the epilepsy surgery program at a …
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Respiratory Biomarkers in Kv1.1 Knockout Mice, a Model for Temporal Lobe Epilepsy
Approximately 1:26 people have epilepsy and around 30% of those cannot effectively treat their seizures with medications, putting them at risk for Sudden Unexpected Death in Epilepsy (SUDEP). We recently demonstrated the progressive nature of epilepsy and mortality in Kv1.1 knockout (KO) mice, a …
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Quantitative MRI correlates of hippocampal and neocortical pathology in intractable temporal lobe epilepsy
Intractable or drug-resistant epilepsy occurs in over 30% of epilepsy patients, with many of these patients undergoing surgical excision of the affected brain region to achieve seizure control. Advances in MRI have the potential to improve surgical treatment of epilepsy through improved …
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The Effects of Smoking on Neuropsychological Functioning Among Patients with Temporal Lobe Epilepsy
… of chronic cigarette smoking in patients with temporal lobe epilepsy (TLE). Smoking is important to study in this population because cognitive profiles are relied on extensively for treatment planning, and thus the discrimination of smoking-related cognitive patterns from those secondary to …
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Neuropsychological Profiles in Temporal Lobe Epilepsy With and Without a History of Traumatic Brain Injury
… deficits have long been observed in those with temporal lobe epilepsy (TLE). Language and verbal memory are often impaired in individuals with left TLE and visuospatial and visual memory can be impaired in patients with right TLE. Traumatic brain injury (TBI) is the most common known cause of …
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ANATOMICAL AND ELECTROPHYSIOLOGICAL STUDIES OF AN ANIMAL MODEL OF TEMPORAL LOBE EPILEPSY WITH CLASSIC HIPPOCAMPAL SCLEROSIS
In mesial temporal lobe epilepsy, seizures often arise from an atrophic hippocampus exhibiting a characteristic pattern of hippocampal neuron loss called "classic hippocampal sclerosis." No single injury has reproduced this extensive neuron loss experimentally, suggesting that hippocampal sclerosis …
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Hypothalamic orexin neurons and tanycytes: Functional and molecular aspects in a mouse model of temporal lobe epilepsy
This dissertation does not include an abstract.
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Effects of lateralized hippocampal damage and pituitary gonadotrope dysfunction in a mouse model of temporal lobe epilepsy
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Disrupted female reproductive cyclicity and gonadotropin-releasing hormone neuron dysfunction in a mouse model of temporal lobe epilepsy
… is a comorbidity that commonly occurs with temporal lobe epilepsy (TLE). However, the neural mechanisms linking epilepsy to comorbid reproductive endocrine disorders are unknown. In the intrahippocampal kainic acid (IHKA) mouse model of TLE, we observed that more than 60% percent of …
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Executive Function in Temporal Lobe Epilepsy: Can markers of disease severity and psychological factors differentiate types of cognitive impairment?
There were two main aims of the current study. The first aim was to examine the effects of markers of disease severity on executive abilities in patients with TLE. Specifically, we were interested in building a model of disease severity that includes seizure duration, seizure frequency, and …
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Developing digital and analog spiking neural Networks for interacting with biological Tissues in the Case Study of temporal lobe Epilepsy
… to pioneer an innovative approach to treating temporal lobe epilepsy by leveraging the symbiotic integration of tissue engineering, neuromorphic engineering, and artificial intelligence (AI). Within this project, my role focused on the neuromorphic engineering aspect, specifically designing a …
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Investigations into the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy and maternal immune activation
… Conditions such as anxiety, autism, and also epilepsy, have been linked to abnormal functioning of the amygdala, owing to improper neurodevelopment or damage. This thesis investigated the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy (TLE) and maternal …
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Test re-test reliability of the Boston Naming Test and the Visual Naming Test on normal subjects with a comparison to subjects with complex partial seizure disorder.
A number of neurological illnesses including temporal lobe epilepsy have been shown to result in deficits of confrontation naming or anomia. The Boston Naming Test (BNT) and the Visual Naming Test (VNT) are both standardized measures of naming ability. Serving as a neurologically intact group, …
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Ethosuximide, a T-type Calcium Channel Antagonist, Reduces Alcohol Withdrawal Seizure
… consequences such as status epilepticus and temporal lobe epilepsy, severe life-threatening conditions that often result in death.
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Hierarchical Bayesian Models for Multimodal Neuroimaging Data
… for poor treatment outcome from a study on temporal lobe epilepsy patients undergoing anterior temporal lobe resection. Second, we propose a multi-subject approach for effective connectivity inference using resting-state functional MRI data. The proposed method provides a joint, single-stage …
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A qualitative analysis of figural memory performance in persons with epilepsy
… nonverbal memory in patients with intractable temporal lobe epilepsy (TLE) on a figural reproduction task, the Rey-Osterrieth Complex Figure (ROCF). The Boston Qualitative Scoring System (BQSS) was used to examine whether qualitative features of ROCF performance could discriminate between those …
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Determining clinically relevant neuropsychological change in an epilepsy sample
… is essential for patients undergoing surgery for temporal lobe epilepsy (TLE). However, potentially confounding issues such as practice effects and low test-retest reliability may influence a person’s test score when they are given the same neuropsychological test on a second occasion, such as …
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