Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Temporal Control"”.
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Advanced technologies for spatio-temporal control of neural circuits using optogenetics
… past decades and it is now possible to optically control the neural activity of genetically targeted cells with techniques known as optogenetic stimulation. The combination of optogenetic stimulation methods with electrophysiological recordings and advanced optical imaging is leading to promising …
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Temporal control of vulval precursor cell fate patterning in Caenorhabditis elegans
… organism requires precise coordination of temporal and spatial cues to ensure that developmental events occur at the correct time and place. C. elegans vulval development offers a convenient experimental system for investigating the temporal and spatial regulation of multiple developmental …
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Spatial and temporal control of lipid-membrane morphology induced by sphingomyelinase
… by different factors. In addition, the flow control by a microfluidic device solves the difficulty of distributing SMase uniformly to membrane systems. Furthermore, the laminar flow in a microchannel allows us to create model membrane arrays with a variety of lipid membrane compositions or …
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Nanoparticle coatings for spatial and temporal control of cancer imaging and therapy
Nature has evolved elegant strategies to temporally and spatially control protein activity, including the synthesis of subunits that require assembly for function, the incorporation of pro-domains that require cleavage for activation, and the formation of inhibitory and stimulatory networks that …
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Regulatory intricacies that confer temporal control of conjugation and antibiotic production functions in Streptomyces: new variations on old themes
… mechanisms involving numerous modes of control have evolved that confer temporal regulation of functions governing these expression programs. Conjugation of the Streptomyces lividans plasmid pIJ101 utilizes only seven plasmid functions in its transmission. Two of these, tra and clt, are …
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOACTIVE MOLECULES LINKED TO PHOTOREMOVABLE PROTECTING GROUPS FOR SPATIO-TEMPORAL CONTROL OF THEIR ACTIVITY THROUGH PHOTOACTIVATION
… phenomena governed by a series of precise spatio-temporal events. Among the most innovative approaches developed over the last decade to investigate such processes, photopharmacology has emerged as a powerful tool, as it exploits light to control biological functions. In particular, …
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Genetic and Molecular Characterization of Programmed Cell Death in the C.elegans Tail-Spike Cell
… destined to die, it remains unclear whether temporal control of cell death is mediated by egl-1 expression. Here, we establish the C. elegans tail-spike cell as an attractive model for studying the initiation of programmed cell death. We show that, while death of the tail-spike cell is …
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Next-Generation Oligonucleotide Probes For Transcriptome In Vivo Analysis (tiva)
… oligonucleotide probe to offer fine spatio-temporal control of mRNA capture. TIVA probes are highly modified RNA hairpins or loops incorporating a poly(U) “capture” sequence complementary to the poly(A) tail of mRNA, as well as a biotin moiety to enable pull-down of bound mRNA. To enable …
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SVILUPPO E PROGETTAZIONE DI SISTEMI FOTOATTIVABILI PER TERAPIE OFTALMICHE
… light stimuli. If produced with accurate spatio-temporal control, these species, can act as “unconventional” therapeutics against infections, glaucoma and macular degeneration. In addition, they also offer two great advantages compared to conventional therapeutic agents: i) absence of multidrug …
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Light-activated gene expression
… provided an opportunity to study the spatial and temporal control of genes by using small synthetic molecules and light. In the late 1990s, we first demonstrated this concept by using as a photo-caged β-estradiol, the hormone for the estrogen receptor (ER). This work opened the door to other …
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FOXO is the Mediator Linking Temporal Differentiation and the Insulin Signaling Pathway
… recently, the molecular mechanism behind the temporal control of differentiation has remained elusive. Bateman and McNeill (2004) revealed a novel role for the insulin/insulin-like growth factor receptor (InR) pathway in regulating the timing of differentiation in neuronal photoreceptor cells …
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Effects of bodyweight and plane of nutrition on mitogenic capacity of mammary extracts in cell culture, mammary growth and development, and protein expression profiles of mammary tissue in Holstein heifers
… but mechanisms governing nutritional and temporal control of mammary development demand further investigation.
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Circadian Regulation of Protein Homeostasis
… report the investigation of post-transcriptional temporal control of protein abundance, and the interplay between protein homeostasis and the circadian clock. I was particularly interested in proteasomal degradation, as it has been implicated in a variety of circadian model systems, and is likely …
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Caged phosphopeptides and phosphoproteins : agents in unraveling complex biological pathways
… because they afford researchers spatial and temporal control over the release of targeted effector molecules. Ligands or proteins involved in signal transduction can be chemically caged and subsequently irradiated to release a concentration burst of a specific species, allowing the downstream …
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RGML: A Specification Language that Supports the Characterization of Requirements Generation Processes
… The RGML can describe process structure, flow of control, and individual activities. Within activities, the RGML supports the characterization of application instantiation, the use of templates and the production of artifacts. The RGML can also describe temporal control within a process as well as …
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Commercial potential for thermal & magnetic sensitive polymer in drug delivery applications
… could be implanted subcutaneously and allow for temporal control of drug release and localized delivery. Current experiments have shown that a prototype device is capable of delivering both small and large molecule drugs. Attractive medical applications for this technology were discovered and …
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Kinematics of developmental coordination disorder : motor control of functional movement skills
… of DCD. After that, a detailed analysis of the control of a simple catching task gives insight into the basic interceptive capacities of children with DCD (Chapter 2). In a second study, the spatio- temporal control and the body kinematics of children with DCD during walking is investigated and …
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Effects of glycosylation on the structure and fibrillization of prion protein fragments
… formation. Additionally, a novel method for the temporal control of fibrillization of this peptide was developed using a synthetic photolabile linker and a "fibril inhibitory unit" positioned at the N-terminus of the peptide. This stabilized the fragment as a soluble monomeric species until …
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Controlled Myogenic Differentiation of Mammalian Cell Lines by Temperature-Inducible Systems
… by changes in temperature, enabling precise control of the expression of an exogenous master gene of myogenesis (MyoD) and a chromatin modifier (SMARCD3). To establish the optimal conditions, we screened different versions of temperature-inducible promoters (with 5, 15, or 45 HSE repetitions) …
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Optogenetic control of developmental signaling pathways
… proper development. Understanding the spatiotemporal intricacies of these pathways necessitates tools which enable their perturbation in precisely defined spatiotemporal patterns. Optogenetics uses light-induced conformational changes to enable or disable protein-protein interactions, thereby …
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