Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Tempol"”.
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TEMPOL and Insulin Resistance: A study of the underlying mechanisms behind changes in glucose metabolism, lipid accumulation and cellular stress
… clinical sequelae. It was hypothesized that TEMPOL, a nitroxide, could suppress diet-induced insulin resistance through its anti-inflammatory and antioxidant properties. To explore this hypothesis, C57BL/6 mice were treated with a high-fat diet to induce obesity-associated insulin resistance, …
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Superoxide via Sp3 Transcription Factor Up-Regulates Renal AT1 Receptor Function and Contributes to Hypertension
… NF-κB proteins. This effect was attenuated with tempol treatment. Furthermore, DETC increased AT1 receptor mRNA and protein expressions, which were attenuated with tempol treatment. However, H2O2 did not have any significant effect on AT1 mRNA expression. Results from transfection studies suggest …
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Mechanisms of High Glucose-induced Decrease in β-cell Function
… Co-infusion of the superoxide dismutase mimetic Tempol decreased total and mitochondrial superoxide, and prevented high glucose-induced β-cell dysfunction in vivo and ex vivo. These results suggest that increased superoxide generation plays a role in β-cell glucotoxicity. In Study 2, 48h glucose …
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Spontaneous tone in deoxycorticosterone acetate-salt hypertensive rats
… Stretch increased 02.- production even further. Tempol, an 02.- scavenger, or apocynin, an inhibitor of NADPH-oxidase, attenuated hypertension. Spontaneous tone was abolished by superoxide dismutase (SOD), tempol, or apocynin in endothelium-intact rings but not in endothelium-denuded rings nor in …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… prevented with 2 weeks of concurrent prazosin or Tempol (a ROS scavenger) administration. Endothelial cell responsiveness to shear stress was partially blunted by CORT pre-treatment. The lack of vascular remodeling (angiogenesis and arteriogenesis) and prevention of GC-mediated capillary …
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Exercise Training Improves Cerebrovascular Oxidative Stress Regulation and Insulin Stimulated Vasodilation in Juvenile and Mature Pigs
… 2) superoxide dismutase (SOD) mimetic (TEMPOL; 1e-4 M) and 3) NAD(P)H Oxidase (NOX) inhibition (Apocynin; 1e-4 M). Physiologic maximum and cumulative change in diameter (AUC) for all groups were compared using a two-way ANOVA (independent variables: age and exercise training). Results: …
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Rhabdomyolysis-induced Acute Kidney Injury in Sickle Cell Disease
… an increase in 4-HNE. The use of antioxidants (TEMPOL, ferrostatin-1, and hydroxyurea) and iron chelators (deferiprone and, potentially, hydroxyurea) were able to ameliorate renal iron accumulation, oxidative stress, lipid peroxidation, and rhabdomyolysis-induced AKI in SS mice. These findings …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
… death. Anti-oxidant such as NAD or GSH, or Mito-TEMPOL were not protective against HG/PA-induced cell death. Second, NAM had a restorative effect on NAD+ depletion was determined whether replenishment of NAD+ prevented HG/PA-induced cell death. Treatment with exogenous nicotinamide mononucleotide …
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Astrocytic communication and cell death during metabolic depression and oxidative stress
… ROS scavengers trolox (a vitamin E analogue), tempol (a superoxide dismutase analogue) or the free radical scavenger cocktail B27 were used. Finally, we investigated the possibility for the astrocytes to recover following a simulated reperfusion injury where metabolic depression was reversed by …
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Endothelial Signal Transduction Pathways Mediating Thrombin and Histamine Stimulation of NO-production. Role of AMP-activated protein kinase
… The inhibiting effects of the SOD-mimetic Tempol on these morphologic changes seen in AMPKα2-downregulated cells and the increased expression of the ER stress marker GRP78 caused by this downregulation also suggested a role for AMPKα2 in oxidant defences. We confirm a pathway dependent on …